Jefferson Researchers

Studies the control and pathology of nematode infections.

Focuses on aphasia and aphasia rehabilitation.

Centers on melanoma, a type of cancer that arises from the transformation of melanocytes.

Explores synthetic organic chemistry, computer-aided drug discovery and the scholarship of teaching and learning in pharmaceutical sciences.

Examines cancer pharmacology and signal transduction focused on treatment and prevention.

Investigates tumor biology and its responses to radiotherapy in both patient samples and preclinical model systems in a variety of tumor types.

Studies GPCR and calcium signaling in brain microvascular endothelial cells and neurons, as well as their implications for blood-brain permeability and autonomic regulation.

Observes how specific interactions between normal bone osteoblasts and breast cancer cells facilitate and maintain breast cancer cell dormancy in bone.

Focuses on interactions between cognitive representations and action planning in healthy individuals and people with neurological or limb‑related conditions.

Centers on identifying mechanisms of drug tolerance and resistance to targeted inhibitors and immunotherapies in melanoma.

Aims to understand the mechanisms that regulate Akt kinase and Protein Kinase A (PKA).

Observes organ growth regulation mediated by Hippo–Yap signaling and the disease mechanisms of early-onset blinding disease caused by Crb1 gene mutations.

Investigates the complex interplay between cardiac myocytes and cardiac fibroblasts, testing therapeutic strategies to mitigate or even halt disease progression.

Explores a variety of clinical outcomes in the rehabilitation field, with an emphasis on acute care and the critically ill.

Explains the structure, function and modulation of voltage-gated potassium (Kv) and sodium (Nav) channels using multidisciplinary team-driven approaches.

Studies the role of RNA binding proteins in primary liver cancer and identifying unique oncogenic drivers to develop novel biomarkers or therapies to improve patient outcomes.

Focuses on pro- and anti-inflammatory lymphocyte subsets that circulate through extralymphoid tissues to identify new ways to modulate tissue infiltrates in inflammation, infection and cancer.

Uses X-ray crystallography and cryo‑EM to study macromolecular machines and assemblies involved in chromatin biology, gene expression and genome maintenance.

Centers on intracellular signaling regulating contraction, relaxation and proliferation of airway smooth muscle with a focus on G protein coupled receptor mediated signaling.

Aims to understand and improve motor recovery after stroke and spinal cord injury.

Identifies the genes, RNAs, proteins and pathways that contribute to cancer cell survival and target these vulnerabilities.

Studies emerging ultrasound applications and their translation to clinical care.

Focuses on the intracellular signaling regulating the contraction of bladder smooth muscle (BSM) with particular emphasis on JNK2 and NFkB mediated signaling.

Examines the role of Sigma1 in tumor metabolism, modulation of the tumor microenvironment and development of novel Sigma1 targeted therapies for advanced prostate cancer.

Analyzes fibrotic diseases that develop due to injury of orthopedically relevant tissues, including joint capsule, tendon, ligament, peripheral nerve and others.

Carries out high‑throughput genomic and expression profiling studies to help translate basic research into medical innovation.

Centers on understanding cytotoxic immune responses against cancer cells and virus-infected cells.

Explores the molecular cell biology of platelet regulation in hemostasis, thrombosis and immune response to modulate platelet function in various contexts.

Studies how the genetic mutations associated with Alzheimer's disease, ALS and frontotemporal dementia impact autophagy using iPSC-derived neurons and glia.

Focuses on the measurement and improvement of functional recovery in neurological conditions like spinal cord injury.

Analyzes aberrant protein phase transitions to develop therapies that block or reverse the formation of fibrils and aggregates connected to various neurodegenerative diseases.

Interprets the molecular impacts of tumor‑suppressor mutations in kidney cancer and uveal melanoma to uncover vulnerabilities for cancer treatment.

Aims to develop new tools for assessment and treatment of chronic liver disease such as metabolic dysfunction-associated steatotic liver disease (MASLD).

Focuses on the interactions between cancer and the immune system.

Investigates how cancer cell-centric phenotypic and genetic changes and tumor‑microenvironment stromal cells drive tumorigenesis, tumor growth and drug resistance.

Examines the neuronal mechanisms of human memory to develop therapeutic interventions for disorders associated with memory impairment.

Examines the neuronal mechanisms of human memory to develop therapeutic interventions for disorders associated with memory impairment.

Analyzes the biochemical, structural and evolutionary biology of tRNAs to develop new strategies for targeting diseases from tRNA dysfunction.

Looks at concussion and subsequent musculoskeletal injury, and the long-term outcomes of repetitive head impact exposure among collision sport athletes.

Identifies genomic biomarkers using liquid biopsy-based approaches and evaluate their values in cancer precision medicine.

Studies stem cell biology and neuroprotection with an emphasis on Parkinson’s disease (PD) and stroke models.

Centers on understanding dendritic cell (DC) biology and developing effective DC vaccines for infectious diseases, autoimmune diseases, allergy and cancer.

Examines proteoglycans, focusing on the coordinated regulation of tumorigenesis, angiogenesis and autophagy.

Looks into the role of DNA repair proteins in PDAC progression and therapy resistance and investigates novel therapeutic strategies.

Observes the role of chromatin regulators and immune interactions in the initiation, relapse and chemotherapy resistance of blood cancers.

Focuses on cancer control behaviors to reduce health disparities, promote cancer awareness and increase survival rates among diverse populations.

Explores materials design, system dynamics, modeling and simulation, composite and polymer characterization, and sustainable manufacturing.

Develops and characterizes controlled-release formulations for implantable and transdermal delivery systems in collaboration with clinical and industry partners.

Looks at the mechanisms that maintain immune homeostasis in peripheral tissues by investigating T‑cell homing, and how immune tolerance to gut microbiota is maintained.

Investigates how short non‑coding RNAs are produced, how they signal within and between cells and how they can be exploited for diagnostics and therapeutics.

Analyzes the molecular and neural mechanisms of sleep and circadian rhythms using the fruit fly (Drosophila melanogaster) as a model system.

Centers on the use of advanced neuroimaging techniques as potential biomarkers in people with spinal cord injury.

Aims to understand the complexities of molecular signaling disrupted in triple-negative breast cancer (TNBC).

Explores integrin‑mediated mechanisms that promote prostate cancer progression, integrating adhesion‑receptor signaling and cancer progression and metastasis.

Focuses on reducing cancer health disparities in vulnerable populations by better understanding the complex factors that contribute to an unequal burden of disease.

Interprets data of behavioral interventions for macular degeneration, biomarkers for prostate and pancreatic cancers and functional assessment in spinal cord injury.

Looks at cellular mechanisms underlying the pathogenesis of traumatic spinal cord injury in experimental models of the disease.

Examines pathologic soft tissue calcification in both genetic disorders and non-hereditary diseases such as kidney stones.

Aims to improve the outcomes of older patients with cancer and multiple comorbidities, who are often excluded from clinical trials.

Analyzes nerve branching, a key step in establishing synaptic connection during neural circuit development.

Studies megakaryopoiesis, thrombosis and hemostasis, with emphasis on understanding G-protein coupled receptor-mediated platelet activation and thrombus formation.

Identifies the mechanisms responsible for myocardial ischemia/reperfusion injury for clinical translational benefit.

Explores how molecular and cellular signaling that underlies tissue homeostasis is co-opted during disease progression.

Investigates the cognitive architecture of speech and language production and its disorders.

Centers on pain, pain perception and alternative methods for dealing with chronic pain.

Explains the molecular and cellular basis for immune memory and self-tolerance in the B cell compartment.

Studies pro-inflammatory pathways in Dendritic cells (DCs) with a focus on phagocytosis and lysosomal function.

Investigates genomics and molecular genetics related to human platelet activation via FcgammaRIIA, and immune-mediated thrombocytopenia and thrombosis syndromes.

Examines the biochemical events that are deregulated to cause alterations in broad transcriptional programs in human cancer.

Looks at how receptor-signaling pathways instruct a cell to obtain its differentiated phenotype and how aberrations in these signaling pathways lead to diseases.

Analyzes how spinal motor neurons and muscle fibers respond to the accumulation of misfolded proteins.

Uses models of human acute myeloid leukemia (AML) to better understand the disease and ultimately identify new targeted therapies for this clinically challenging cancer.

Explores the role of platelets in thrombosis, with an emphasis on exploring the interactions between platelets and other blood cells.

Studies language production, learning and language change, and rehabilitation of acquired language impairment (aphasia).

Develops new reagents and strategies for organic synthesis and applying them in the synthesis of medicinally interesting targets.

Centers on establishing neuroimaging biomarkers using MRI and developing tools to measure these biomarkers, including an imaging template for the pediatric spinal cord.

Studies, broadly, how synapse organization arises in the brain and how that organization enables behavior.

Focuses on developing, validating and using outcome measures for individuals with spinal cord injury and other conditions.

Examines patient adherence to cancer screening, shared decision-making and disparities in cancer prevention and control within underserved, high-risk populations.

Develops therapeutic strategies to interrupt the progress of cardiovascular diseases and cancer by identifying several novel gene products that play key regulatory roles.

Optimizes and improves the precision of neurotherapeutic approaches for neurological injuries or diseases.

Centers on developing therapies to treat prostate cancer, which is the most common non-skin cancer in men in Western countries.

Explores the progression and potential vulnerabilities of pancreatic and hepatobiliary cancers, focusing on targeting cancer metabolism and surgical innovation.

Investigates the intersections of architecture, cities and interior space with media, representation and visual culture.

Focuses on host-pathogen interactions – specifically the pathogenesis of Chlamydia trachomatis, which is the most frequently reported bacterial STD.

Studies how GPCR signaling and functions are regulated by arrestins and GPCR kinases (GRKs), primarily in airway smooth muscle.

Analyzes how memory and perception systems support diverse cognitive functions.

Centers on gaining a better understanding of colorectal cancer.

Targets optimizing performance and participation in people with Alzheimer’s disease and other dementias, frail elders and their caregivers.

Aims to better understand athletic injury etiology, risk reduction and rehabilitation.

Explores the psychosocial factors that confer resilience after brain injury, with an interest in self-regulation as a key mechanism.

Identifies and characterizes key proteins and pathways that regulate cardiac inflammation in pathological conditions such as diabetes mellitus, sepsis and cardiac injury.

Examines how toll like receptor and cytokine signaling promote B cell responses in extrafollicular and germinal center pathways in lupus and protective immunity.

Studies the biogenesis and function of short regulatory non-coding RNAs.

Addresses disparities in therapy access and utilization by engaging culturally diverse communities and making interventions culturally responsive.

Looks into the adaptation of nucleus pulposus cells to the unique hypoxic and hyperosmolar microenvironment niches of the intervertebral disc.

Investigates improving the quality and capacity of the US acute care delivery system to best serve individual patient needs.

Centers on neurodevelopmental outcomes in children with X and Y chromosome disorders, with over 25 years of NIH-funded pediatric clinical research.

Analyzes Alzheimer’s disease, racial health disparities in African Americans with diabetes, as well as vision related depression and disability.

Studies molecular mechanisms of membrane receptors and channels that facilitate cellular signal transduction.

Aims to advance personalized breast cancer care and is recognized for its work on molecular profiling of hormone receptor-positive breast cancer.

Looks into effective treatments for metastatic uveal melanoma, from the bench to clinical practice and from clinical observation back to the bench.

Examines how processing and integrating sensory information impacts daily participation in children with autism and other developmental disorders.

Develops vaccines based on highly attenuated rabies and measles viruses, and studies the biochemistry, molecular biology and immunology of the rabies virus.

Investigates metabolic adaptation in cancer cells through the use of cell biology, biochemistry and metabolomics.

Focuses on finding small molecules with improved function against known targets and create expressed sources of molecular diversity to identify and validate novel targets.

Screens agents that inhibit overactive enzymes or proteins to suppress cell cycle progression, proliferation and malignant growth of cancer cells.

Aims to develop and test wearable and implantable neurotechnology for adults and children who live with weakness and paralysis from stroke or other neurological injury.

Studies liver cancer and transplant immunology – specifically resistance to CAR-T therapy in HCC and novel implementations of CAR-T in immune tolerance.

Aims to improve health and cure disease through toning mitochondrial energetics, Ca2+ and redox signaling.

Investigates viral pathogenesis, immunology and vaccines.

Centers on metabolic reprogramming, radiation toxicity and cancer health disparities to allow for leading-edge science to be delivered directly to patients.

Explores the cell biology of Parkinson’s disease, focusing on mechanisms of neurodegeneration and neuroprotection.

Studies the basic, translational and clinical aspects of gastrointestinal biology and tumorigenesis.

Investigates the interaction of CMV with the immune system and the in different tissues over the lifespan of the host.

Pursues translational research in end-stage liver disease, liver transplantation and prostate cancer.

Analyzes the roles of extracellular vesicles (EVs) in neurological disorders and vascular dysfunction.

Aims to gain a better understanding of the mechanisms that regulate hemostasis and thrombosis in vivo.

Centers on uncovering the molecular and cellular mechanisms that contribute to organ dysfunction following pulmonary injury.

Provides clinical translation for the prevention and treatment of cardiovascular diseases.

Focuses on understanding immunobiology of cytotoxic lymphocytes.

Targets organ replacement therapy including assisted circulation and cardiac transplantation.

Studies precise sensory and motor control mechanisms to improve motor rehabilitation protocols for individuals with neurological disorders.

Aims to define the underlying mechanisms responsible for biomechanical, neuromuscular and tissue adaptations to repetitive stress.

Performs foundational research on mitochondrial disorders, mitochondrial DNA mutations and mitochondrial stress signaling.

Determines novel mechanisms that augment bone strength and induce the rapid repair of skeletal fractures.

Investigates functional and structural brain connectivity in epilepsy as measured by rsfMRI, tfMRI, DWI, PET and high-resolution anatomical MRI.

Deciphers the molecular and cellular neurodegenerative mechanisms in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Revolves around HIV and drugs of abuse focusing mainly on transcriptional and epigenetic aspects.

Studies moderate-severe TBI as a chronic disability, particularly in its intersection with aging and age-related medical complications.

Explores applied health services research and clinical trials for diverse diseases, with a special focus on advanced liver diseases.

Examines the role of parathyroid hormone (PTH)/PTH related protein (PTHrP)–activated PTH receptor in musculoskeletal diseases.

Looks at the mechanisms that regulate membrane binding, trafficking and novel signaling functions of G proteins and other signaling proteins at distinct subcellular locations.

Aims to improve treatments and care for heart failure patients and improving clinical research processes to reduce burdens on physician researchers.

Analyzes how cognitive-motor interactions allow us to acquire and maintain skilled actions and become movement experts.

Conducts translational research to advance neuroimaging to improve the future of epilepsy and DBS surgery, as well as better understand the brain and its networks.