Belani Research

Our research integrates synthetic organic chemistry, computer-aided drug discovery, and the scholarship of teaching and learning in pharmaceutical sciences.

In C–H activation, we focus on developing novel methodologies to functionalize otherwise inert carbon–hydrogen bonds, enabling more efficient, selective, and sustainable synthesis of complex, drug-like molecules. These approaches employ transition-metal catalysis, tailored ligand design, and reaction optimization for regio- and stereoselectivity, with applications in late-stage functionalization of bioactive compounds.

In computer-aided drug design (CADD), we use molecular docking, molecular dynamics simulations, and structure-based virtual screening to identify and optimize lead compounds targeting therapeutically relevant proteins. Recent projects have included repurposing FDA-approved drugs for focal adhesion kinase inhibition, exploring structure–activity relationships, and integrating computational predictions with in vitro validation to accelerate the drug discovery process.

In pedagogy, we design, implement, and evaluate innovative teaching strategies in medicinal chemistry and related disciplines. Notable work includes the development of a functional group analysis activity that measurably improved student understanding and application of chemical principles over three years. This research advances evidence-based teaching practices and supports student success in PostBac, PharmD, and graduate programs.