Heterocycles are widespread among molecules of biological relevance. Saturated heterocycles such as morpholines and tetrahydropyrans are of particular interest in medicinal chemistry, as the three-dimensional nature of these rings can contribute improved drug-like properties. Numerous methods to construct saturated heterocycles exist, but few operate under highly mild conditions and tolerate various substituents with unprotected functional groups. We are developing the concept of blue LED-enabled radical/polar crossover annulation reactions (RPAR) to create heterocycles from nitrogen and carbon-centered radicals. 

Ongoing research aims to develop 3D printed devices for conducting light-triggered chemical reactions. These devices are being designed in collaboration with experts in Jefferson’s Kanbar College of Design, Engineering and Commerce (DEC). Unlike traditional chemistry reactors, these are designed to be inexpensive, easily adaptable and portable, potentially enabling the preparation of molecules used in medicine or agriculture “on demand”. These devices are used to develop new organic photochemical reactions, including reactions that are useful for the preparation of undersupplied medicines.