Mohamed Research

Contact

Name: Feroze Mohamed, PhD
Position: Director, Jefferson Integrated MRI Center

909 Walnut Street
COB 140R
Philadelphia, PA 19107

Telephone: 215-955-3405

Dr. Feroze Mohamed received his PhD in Biomedical Engineering from Drexel University in 1996. He is currently the Director of Jefferson Integrated Magnetic Resonance Imaging Center (JIMRC) at Thomas Jefferson University and has a demonstrated record of extensive work and publications in fMRI, structural MRI and Diffusion Tensor Imaging over the last two decades. He has served as a PI, co-PI, and co-Investigator on NIH, private foundation and industrial grants. These grants have been primarily in the development and new applications of MRI methods (BOLD, DTI, DWI etc.) for patient as well as normative subjects of the central nervous system (CNS: Brain & Spine).

About JIMRIC

Jefferson Integrated Magnetic Resonance Imaging Center (JIMRIC) currently provides clinical and research support to the Hospital and University Enterprise at TJU. We currently make it available to the neuroscience community advanced neuroimaging techniques for structural and functional imaging to study diseases such as tumors, epilepsy, Parkinson’s, Autism, and spinal cord injury to name a few.  The center also provides support to Brind Marcus center of integrative health and plans are underway to start collaborations with cardiothoracic radiology for advanced imaging of the heart. The MR imaging technologies currently we use at TJU are not leading edge and we are falling behind rapidly from what is available at other leading neuroscience centers and would benefit from high end 3T scanners with connectome gradients. The program would also greatly benefit from a dedicated animal MR scanner by providing support for programs such as spinal cord injury, ALS, MS, Epilepsy and Parkinson’s to name a few. JIMRIC also currently trains doctoral and post-doctoral students in engineering and physics, fellow and residents from Radiology, Neurology, Neurosurgery and medical students from TJU and other local institutions.

Research Projects

Neuroimaging based on DTI as a biomarker for spinal cord injury in children

The purpose of this project is to establish neuroimaging criteria based on diffusion tensor imaging (DTI) for evaluating the location and severity of spinal cord injury in children and youths among four ASIA Impairment Scale (AIS) classifications (A, B, C/D and E).

5R01NS079635-03: PI: Feroze B. Mohamed, PhD                   
09/01/13 – 12/31/18

Metal Artifact Characterization in Spinal Cord Injury

This project is to designed, test and optimize metal suppression magnetic resonance (MR) pulse sequences in spinal implants using in-vitro phantom models and later to evaluate these pulse sequences in spinal cord injury (SCI) patients with metal implants, and establish guidelines for reliably imaging the spinal cord under these conditions.

Craig Neilson Foundation: PI: Feroze B. Mohamed, PhD
10/01/16 – 10/01/19                                  

The Neural Basis of Social Knowledge

This project will provide critical information about the neural basis of social knowledge as well as providing information as to how the individual variation in social processing is reflected in variability in structural connectivity of the limbic white matter tracts.

2R01MH091113-06: PI: Ingrid Olsen, PhD 
Role: Co-Investigator: Feroze B. Mohamed, PhD                                             
09/01/15 – 5/31/20

Reliability Assessment of Subjective & Objective Measures of Spinal Cord Injury using the NINDS SCI MRI CDE Instrument

The overall objective of this project is to establish the level of reliability of the NINDS recommended subjective and objective MRI assessment of SCI with the following two distinct goals:

  1. Establish inter-rater reliability of the subjective features of SCI as catalogued in the NINDS CDE collection for MRI.
  2. Establish the reliability of the objective spinal cord DTI metrics on multi-vendor clinical MRI platforms at various field strengths.

Craig Neilson Foundation: PI: Flanders A, MD, co-PI, Mohamed FB, PhD  
1/01/17 – 12/30/19

Risk for Bipolar Disorder: Reward-related Brain Function & Social Rhythms

=Very little is known about the mechanisms underlying BAS dysregulation that lead to bipolar mood symptoms/episodes. The overall goal of this proposal is to address this important gap in adolescents at risk both for BSD and heightened reward sensitivity. 

5R01MH077908-08: PI: Lauren Alloy, PhD                                             
Role: Co-Investigator: Feroze B. Mohamed, PhD
09/01/15 – 4/30/18