Wang Research
Contact
Positions:
- Associate Professor, Department of Medicine - Division of Endocrinology, Diabetes & Metabolic Diseases
- Director, Animal Model Core, Center for Translational Medicine
1020 Locust Street
JAH, Room 543E
Philadelphia, PA 19107
Email:
Bin.Wang@jefferson.edu
Contact Number(s):
Dr. Wang’s research focuses on the investigation of role of parathyroid hormone (PTH)/PTH related protein (PTHrP)–activated PTH receptor in musculoskeletal diseases. The ultimate goal of my research is to advance knowledge in the fields of GPCR biological and musculoskeletal disease research and translate the scientific discoveries for the prevention and treatment of osteoporosis and other musculoskeletal diseases.
Research Projects
Dr. Wang's laboratory is investigating the roles of parathyroid hormone (PTH)/PTH related protein (PTHrP)–activated PTH receptor in musculoskeletal diseases.
Characterization of bimodal effects of PTH on bone metabolism. The long-term objective is to identify new compounds that can enhance the anabolic effect of PTH or PTHrP for the treatment of osteoporosis.
Determining whether and how PTHrP plays a pathogenic role in articular cartilage degeneration (osteoarthritis) during aging.
Characterization of the interaction of PTH receptor with other GPCRs, such as ovarian cancer G protein-coupled receptor 1 (OGR1). The purpose of this research will illustrate how PTH receptor coordinates with other GPCRs to maintain musculoskeletal homeostasis.
