Peisong Ma Research

Peisong Ma

Contact

Name: Peisong Ma, PhD
Position: Assistant Professor

1020 Locust Street, Room 394
Philadelphia, PA 19107

Telephone: 215-955-3966
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Dr. Ma’s laboratory is involved with investigating thrombosis and hemostasis, with a special emphasis on understanding GPCR (G-protein coupled receptor) and G-protein mediated platelet activation. Many antiplatelet drugs target GPCRs and G protein signaling pathways. Our current studies provide novel insights into the regulatory mechanisms that allow platelets to produce an optimal response to vascular injury. Using well-established vascular injury models, CRISRP-Cas9 genome-editing, and biochemical approaches, we have provided strong evidence that defects in GPCR and G-protein signaling pathways translate into in vivo phenotypes.    

Research Projects

The function of GRKs in hemostasis and thrombosis

We have recently provided strong evidence that GPCR kinases (GRKs) are critical negative regulators during platelet activation. Our goals are to investigate how GRKs regulate GPCRs during platelet activation and thrombus formation.

The regulatory networks that regulate platelet activation

Current studies are investigating novel positive regulators and negative regulators in response to GPCR-coupled agonists using genome-wide CRISPR-Cas9 screen. 

RGS-insensitive Gq (G188S) as probes of G protein functions

An ongoing study is to characterize the effect of G188S mutation on platelet function and thrombus formation downstream of GPCR-dependent signaling pathways.