Jefferson Center for Vaccines & Pandemic Preparedness Research
Contact
Position:
Chair & Professor, SKMC Department of Microbiology & Immunology
233 South Tenth Street
Bluemle Life Sciences Building, 531
Philadelphia, PA 19107
Contact Number(s):
Position:
Associate Director for Basic Research
Position:
Associate Director for Clinical Research
Center Information
Position:
JCVPP Administrator
Email:
Cheryl.King@jefferson.edu
Basic Immune Functions
We are uncovering novel mechanisms regulating immune responses.
Faculty Research/Lab Sites & Publications
Names are linked to their respective lab web sites or academic profiles.
Gudrun Debes, PhD
Associate Professor, Department of Microbiology & Immunology
Gudrun Debes, PhD
Associate Professor, Department of Microbiology & Immunology
Publications
- Secreted IgM modulates IL-10 expression in B cells
- The Lack of Natural IgM Increases Susceptibility and Impairs Anti-Vi Polysaccharide IgG Responses in a Mouse Model of Typhoid
- Immunoregulation by antibody secreting cells in inflammation, infection, and cancer
- Skin-Homing Regulatory B Cells Required for Suppression of Cutaneous Inflammation
- Approaches to overcome flow cytometry limitations in the analysis of cells from veterinary relevant species
Claudio Giraudo, PhD
Associate Professor, Department of Microbiology & Immunology
Publications
- Extended-Synaptotagmin-1 and -2 control T cell signaling and function
- Novel Compound Heterozygous ZAP70 R37G A507T Mutations in Infant with Severe Immunodeficiency
- Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling
- Analysis of immune synapses by τau-STED imaging and 3D-quantitative colocalization of lytic granule markers
- Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation
Botond Igyarto , PhD
Professor, Department of Microbiology & Immunology
Publications
- Dendritic cells overcome Cre/Lox induced gene deficiency by siphoning cytosolic material from surrounding cells
- The mRNA-LNP vaccines – the good, the bad and the ugly?
- Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells
- Intracellular monitoring by dendritic cells – a new way to stay informed – from a simple scavenger to an active gatherer
- Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion
Sangwon Kim, PhD
Associate Professor, Department of Microbiology & Immunology
Publications
- Author Correction: GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome(Nature Cardiovascular Research, 10.1038/s44161-023-00401-z)
- GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
- Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity
- Improved approach for the cryopreservation of mouse sperm by combining monothioglycerol and L-glutamine
Adriana Mantegazza, PhD
Assistant Professor, Department of Microbiology & Immunology
Adriana Mantegazza, PhD
Assistant Professor, Department of Microbiology & Immunology
Publications
- Examining the Kinetics of Phagocytosis-Coupled Inflammasome Activation in Murine Bone Marrow-Derived Dendritic Cells
- Dissecting Phagosomal Pattern Recognition Receptor-Dependent Signaling and Antigen MHC-II Presentation from Phagosomes in Murine Dendritic Cells
- The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells
- A guide to measuring phagosomal dynamics
- Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells
Zia Rahman, MD, PhD
Professor, Department of Microbiology & Immunology
Zia Rahman, MD, PhD
Professor, Department of Microbiology & Immunology
Publications
- STAT3 signaling in B cells controls germinal center zone organization and recycling
- Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
- B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling
- The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes
- Regulation of B cell responses in sle by three classes of interferons
Carolina R. Melo-Silva, PhD
Instructor, Department of Microbiology & Immunology
Publications
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
- Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine
Luis Sigal, DMV, PhD
Professor, Department of Microbiology & Immunology
Publications
- The roles of CD4+ T cell help, sex, and dose in the induction of protective CD8+ T cells against a lethal poxvirus by mRNA-LNP vaccines
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
Christopher Snyder, PhD
Associate Professor, Department of Microbiology & Immunology
Publications
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Mechanisms of antiviral cytotoxic cd4 t cell differentiation
- Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation
- Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion
- STING sensing of murine cytomegalovirus alters the tumor microenvironment to promote antitumor immunity