Jefferson Center for Vaccines & Pandemic Preparedness Research
Contact
Position:
Chair & Professor, SKMC Department of Microbiology & Immunology
233 South Tenth Street
Bluemle Life Sciences Building, 531
Philadelphia, PA 19107
Contact Number(s):
Name:
Christopher M. Snyder, PhD
Position:
Associate Director for Basic Research
Name:
Christopher Chambers, MD
Position:
Associate Director for Clinical Research
Center Information
Name:
Cheryl King-Marino
Position:
JCVPP Administrator
Email:
Cheryl.King@jefferson.edu
Host/Pathogen Interactions for the Development of Novel Anti-microbials & Host-targeted Therapies for Infectious Disease
We are exploring how pathogens and hosts interact on the molecular level with the goal of developing novel anti-microbials or host-targeted therapies to alleviate disease.
Faculty Research/Lab Sites & Publications
Names are linked to their respective lab web sites or academic profiles.
Drishya Kurup, PhD
Research Instructor, Department of Microbiology & Immunology
Publications
- Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease
- Toward the Development of a Pan-Lyssavirus Vaccine
- Effects of adjuvants in a rabies-vectored Ebola virus vaccine on protection from surrogate challenge
- Inactivated rabies-vectored SARS-CoV-2 vaccine provides long-term immune response unaffected by vector immunity
- Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract
Felix Kim, PhD
Professor, Department of Microbiology & Immunology
Publications
- A student-community partnership to enhance cancer research training
- Prostein expression on circulating tumor cells as a prognostic marker in metastatic castration-resistant prostate cancer
- Sigma1 Regulates Lipid Droplet-Mediated Redox Homeostasis Required for Prostate Cancer Proliferation
- Review of Cardiovascular Risk of Androgen Deprivation Therapy and the Influence of Race in Men with Prostate Cancer
- Haloperidol and Prostate Cancer Prevention: More Epidemiologic Research Needed
Holly Ramage, PhD
Assistant Professor, Department of Microbiology & Immunology
Publications
- Correction: Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core (Journal of Biological Chemistry (2013) 288(14) (9915–9923), (S0021925820673525), (10.1074/jbc.M112.434910))
- Motif-VI loop acts as a nucleotide valve in the West Nile Virus NS3 Helicase
- Serotonin reduction in post-acute sequelae of viral infection
- IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding
- A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model
Carolina R. Melo-Silva, PhD
Instructor, Department of Microbiology & Immunology
Publications
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
- Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine
Luis Sigal, DMV, PhD
Professor, Department of Microbiology & Immunology
Publications
- The roles of CD4+ T cell help, sex, and dose in the induction of protective CD8+ T cells against a lethal poxvirus by mRNA-LNP vaccines
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
Christopher Snyder, PhD
Associate Professor, Department of Microbiology & Immunology
Publications
- Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Mechanisms of antiviral cytotoxic cd4 t cell differentiation
- Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation
- Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion