We are developing novel approaches to vaccination in order to target some of the worlds more important infectious diseases.
Jefferson Center for Vaccines & Pandemic Preparedness Research
Contact
Position:
Chair & Professor, SKMC Department of Microbiology & Immunology
233 South Tenth Street
Bluemle Life Sciences Building, 531
Philadelphia, PA 19107
Contact Number(s):
Name:
Christopher M. Snyder, PhD
Position:
Associate Director for Basic Research
Name:
Christopher Chambers, MD
Position:
Associate Director for Clinical Research
Center Information
Name:
Cheryl King-Marino
Position:
JCVPP Administrator
Email:
Cheryl.King@jefferson.edu
Vaccine Design, Delivery & Immune Responses
We are developing novel approaches to vaccination in order to target some of the worlds more important infectious diseases.
Faculty Research/Lab Sites & Publications
Names are linked to their respective lab web sites or academic profiles.
David Abraham, PhD
Professor, Department of Microbiology & Immunology
Publications
- Development of Dirofilaria immitis adult worms in NSG mice, detection of parasite-derived microRNA and comparative analysis of laboratory isolates
- Vaccination against Onchocerca volvulus induces IgG-mediated protective immunity dependent on neutrophils and complement
- Closing the Communication Gap: Assessing the Alignment Between UME and GME Competencies
- A rodent model for Dirofilaria immitis, canine heartworm: parasite growth, development, and drug sensitivity in NSG mice
- Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to Onchocerca volvulus in Mice and Non-Human Primates
Botond Igyarto, PhD
Professor, Department of Microbiology & Immunology
Publications
- Langerhans cells drive Tfh and B cell responses independent of canonical cytokine signals
- Dendritic cells overcome Cre/Lox induced gene deficiency by siphoning cytosolic material from surrounding cells
- The mRNA-LNP vaccines – the good, the bad and the ugly?
- Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells
- Intracellular monitoring by dendritic cells – a new way to stay informed – from a simple scavenger to an active gatherer
Drishya Kurup, PhD
Research Instructor, Department of Microbiology & Immunology
Publications
- Immunogenicity and efficacy of a rabies-based vaccine against highly pathogenic influenza H5N1 virus
- Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
- Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle
- Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease
- Toward the Development of a Pan-Lyssavirus Vaccine
Adriana Mantegazza, PhD
Assistant Professor, Department of Microbiology & Immunology
Publications
- The lysosomal carrier SLC29A3 supports antibacterial signaling, and promotes autophagy by activating TRPML1 in murine dendritic cells
- Examining the Kinetics of Phagocytosis-Coupled Inflammasome Activation in Murine Bone Marrow-Derived Dendritic Cells
- Dissecting Phagosomal Pattern Recognition Receptor-Dependent Signaling and Antigen MHC-II Presentation from Phagosomes in Murine Dendritic Cells
- The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells
- A guide to measuring phagosomal dynamics
Carolina R. Melo-Silva, PhD
Instructor, Department of Microbiology & Immunology
Publications
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
- Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine
Matthias Schnell, PhD
Chair, Department of Microbiology & Immunology
Dr. V. Watson Pugh & Frances Plimpton Pugh Professor in Microbiology & Immunology
Director, Jefferson Center for Vaccines & Pandemic Preparedness
Publications
- Immunogenicity and efficacy of a rabies-based vaccine against highly pathogenic influenza H5N1 virus
- Rabies virus-vectored Lyme disease vaccine provides long-term protection against tick-transmitted Borrelia burgdorferi
- Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle
- Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease
- Toward the Development of a Pan-Lyssavirus Vaccine
Luis Sigal, DMV, PhD
Professor, Department of Microbiology & Immunology
Publications
- Activation of CD8 T cells during Viral Infections
- The roles of CD4+ T cell help, sex, and dose in the induction of protective CD8+ T cells against a lethal poxvirus by mRNA-LNP vaccines
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
Christopher Snyder, PhD
Associate Professor, Department of Microbiology & Immunology
Publications
- Persistent microglial activation following neonatal CMV infection mediates neurodegeneration
- Leukotriene B4 regulates T cell recognition and control of MCMV in mucosal tissues
- Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Mechanisms of antiviral cytotoxic cd4 t cell differentiation