Jefferson Office of Human Research Protection

1. Create a New Study Application in iRIS. 
2. In Section 5.0, indicate who will serve as the IRB of Record. 
3. In Section 6.0, be sure to include the sponsor. 
4. Upload the following documents: 
   • Authorization Agreement with your submission. 
     • The authorizations can be found on the Forms Page under Agreement Templates. 
   • ICF to be submitted (can be working draft)
   • Ancillary approval(s) or parallel review memo(s). 
5. Route submission for review. 
   • Per Jefferson IRB Policy, signatures are required from the Principal Invesitgator, Department Chair, and Business Administrator. 
   • If you are not able to route for signature within iRIS, you may attach an iRIS Signature Page with the required signoffs. 
6. A JOHRP Analyst will review your submission and sign the Authorization Agreement.  

• The PI and study team remain responsible for ensuring all Jefferson IRB reporting requirements are maintained throughout the life of the study.
• The PI and study team are required to submit continuing review and closure notices via the External IRB – Annual Update and Closure form in iRIS.

If you have questions at any time throughout this process, please reach out to Steven Muller, Steven.Muller@jefferson.edu or Lauren Boccardo, Lauren.Boccardo@jefferson.edu.