Stoffers B, Bräuninger H, Bacmeister L, Kupsch S, Antonela Vico T, Marchini T, Brehm M, Yan I, Becher P, F Escher, Kim SV, Klingel K, Kirchhof P. Blankenberg S, Zeller T, Wolf D, Hilgendorf I, Westermann D, Lindner D. GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome. Nature Cardiovascular Research. 2023 Dec 27; 3: 76-93. DOI: 10.1038/s44161-023-00401-z.

Van NT, Zhang K, Wigmore RM, Kennedy AI, DaSilva CR, Huang J, Ambelil M, Villagomez JH, O’Connor GJ, Longman RS, Cao M, Snook AE, Platten M, Kasenty G, Sigal L, Prendergast GC, Kim SV. Dietary L-Tryptophan consumption determines the number of colonic regulatory T-cells and susceptibility to colitis via GPR15. Nature Communications. 2023 Nov 14; 14(1):7363. PMID: 37963876; PMCID: PMC10645889; DOI:10.1038/s41467-023-43211-4.

This paper describes how dietary tryptophan activates AhR to induce GPR15 expression, preferentially among Tregs, and affects colitis. 

Larson JH, Jin S, Loschi M, Wagners SB, Thangavelu G, Zaiken MC, McDonald-Hyman C, Saha A, Aguilar EG, Koehn B, Osborn MJ, Panoskaltsis-Mortari A, Macdonald KPA. Hill GR, Murphy WJ, Serody JS, Maillard I, Kean LS, Kim SV, Littman DR, Blazar BR. Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity. American Journal of Transplantation. 2023 Aug:23(8):1102-1115. PMID: 36878433; PMCID: PMC10475494; DOI: 10.106/j.ajt.2023.01.030.

 Enforcing homing of Tregs to the intestine could allevaite GI symptoms in GVHD.

Van NT, Kim SV. Improved approach for the cryopreservation of mouse sperm by combining monothioglycerol and L-glutamine. Cryobiology. 2023 Jun:111:142-145. PMID:37001845;PMCID:PMC10247421; DOI:10.1016/j.cryobiol.2023.03.005.

This paper provides the most improved protocol for the cryopreservation of mouse sperm.

Melo-Silva CR, Knudson CJ, Tang L, Kafle S, Springer LE, Choi J, Snyder CM, Wang Y, Kim SV, Sigal LJ. Multicple and consecutive genome editing using i-GONAD and breeding enrichment facilitates the production of genetically modified mice. Cells. 2023 May 8; 12(9):1343. PMID: 37174743; PMCID: PMC10177031; DOI: 10.3390/cells12091343.

Haase T, Müller C, Stoffers B, Kirn P, Kirn P, Waldenberger M, Kaiser FJ, Karakas M, Kim SV, Voss S, Wild, PS, Lackner KJ, Andersson J, Söderberg S, Lindner D, Zeller T. G protein-coupled receptor 15 expression is associated with Myocardial infarction. International Journal of Molecular Sciences. 2022 Dec 22; 24(1):180. PMID: 36613626; PMCID: PMC9820726; DOI: 10.3390/ijms24010180.

Cardona SM, Kim SV, Church, KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich S, Parker-Thornburg J, Ospina A, Araque P, Ransohoff RM, Cardona AE. Role of the fractalkine receptor in CNS autoimmune inflammation: New approach utilizing a mouse model expressing the human CX₃CR1^I249/M280 variant. Frontiers in Cellular Neuroscience. 2018 Oct 17:12:365. PMID: 30386211; PMCID: PMC6199958; DOI: 10.3389/fncel.2018.00365.

Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR. Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity. Cold Spring Harbor Symposia on Quantitative Biology. 2013; 78:193-201.  PMID: 24913313; PMCID: PMC4367195 DOI: 10.1101/sqb.2013.78.020081.

This review paper describes how microbiota contributes to compartmentalization of host immune responses and its impact in T cell-mediated, organ-specific autoimmune diseases.

Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013. June 21; 340 (6139): 1456-9. PMID: 23661644; PMCID: PMC3762262; DOI: 10.1126/science.1237013.

This paper describes for the first time T cell homing receptor for the large intestine, GPR15 and its role in local enrichment of regulatory T cells to maintain immune homeostasis in the large intestine.

Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka R, Chow J, Manel N, Ciofani, MC, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORgt activity. Nature. 2011 April 28; 472(7344): 486-90. PMID: 21441909; PMCID: PMC3172133; DOI: 10.1038/nature09978.

This paper describes the identification of Digoxin and its derivatives as novel RORgt inhibitors, and showed that they can suppress Th17 cell differentiation.