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Bluemle Life Science Building, Room 728
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Highlighted Publications
Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26; 351(6276): 933-9. PMID: 26822608; PMCID: PMC4782964; DOI: 10.1126/science.aad0314.
This paper describes that material immune activation during pregnancy can induce autisms spectrum disorder in offspring and that it is dependent on RORgt and interleukin-17A expression.
Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR. Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity. Cold Spring Harbor Symposia on Quantitative Biology. 2013; 78:193-201. PMID: 24913313; PMCID: PMC4367195 DOI: 10.1101/sqb.2013.78.020081.
This review paper describes how microbiota contributes to compartmentalization of host immune responses and its impact in T cell-mediated, organ-specific autoimmune diseases.
Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013. June 21; 340 (6139): 1456-9. PMID: 23661644; PMCID: PMC3762262; DOI: 10.1126/science.1237013.
This paper describes for the first time T cell homing receptor for the large intestine, GPR15 and its role in local enrichment of regulatory T cells to maintain immune homeostasis in the large intestine.
Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka R, Chow J, Manel N, Ciofani, MC, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORgt activity. Nature. 2011 April 28; 472(7344): 486-90. PMID: 21441909; PMCID: PMC3172133; DOI: 10.1038/nature09978.
This paper describes the identification of Digoxin and its derivatives as novel RORgt inhibitors, and showed that they can suppress Th17 cell differentiation.
Publications
- GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
- Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity
- Improved approach for the cryopreservation of mouse sperm by combining monothioglycerol and L-glutamine
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- G Protein-Coupled Receptor 15 Expression Is Associated with Myocardial Infarction
- Role of the fractalkine receptor in CNS autoimmune inflammation: new approach utilizing a mouse model expressing the human CX3CR1I249/M280 variant
- Erratum to: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Nature, (2015), 528, 7583, (517-522), 10.1038/nature16193)
- Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions
- The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
- DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions
- Microbiota: Host interactions in mucosal homeostasis and systemic autoimmunity
- GPR15-mediated homing controls immune homeostasis in the large intestine mucosa
- Digoxin and its derivatives suppress T H17 cell differentiation by antagonizing RORγ3t activity
- Disruption of myosin 1e promotes podocyte injury
- Myosin I: From yeast to human
- Modulation of cell adhesion and motility in the immune system by Myo1f
- Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor ζ chain ITAMs and their tyrosine residues
- CD8αα and T Cell Memory
- A pool of central memory-like CD4 T cells contains effector memory precursors