Kim Research

Mar 23   Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.  

Mar 23   PERK is a critical metabolic hub for immunosuppressive function in macrophages.

Mar 16   Marginal zone B cells acquire dendritic cell functions by trogocytosis.

Mar 16   CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.

Mar 9   Microbiota regulate social behaviour via stress response neurons in the brain.

Mar 9    A gut-derived metabolite alters brain activity and anxiety behaviour in mice.

Mar 2     Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite.

Mar 2    Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome.

Feb 23    Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis .      

Feb 23    Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM.

Feb 16     Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron.

Feb 16    T cell responses to SARS-CoV-2 spike cross-recognize Omicron.

Feb 9      Insular cortex neurons encode and retrieve specific immune responses.   

Feb 9      Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.   

Feb 2      Transmission of trained immunity and heterologous resistance to infections across generations (This is a paper that we already discussed in the last semester). There are two letters submitted regarding the main message of that paper. We will discuss those. 

-   Lack of evidence for intergenerational inheritance of immune resistance to infections.

-   Reply to: ‘Lack of evidence for intergenerational inheritance of immune resistance to infections’. 

Feb 2      A prenylated dsRNA sensor protects against severe COVID-19.

Jan 26    Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.

Jan 26    An NK-like CAR T cell transition in CAR T cell dysfunction. 

Jan 19    Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2.

Jan 19    Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.  

Jan 19    Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.

Jan 19    Considerable escape of SARS-CoV-2 Omicron to antibody neutralization.      

Jan 19    Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift.   

Jan 12    Fam72a enforces error-prone DNA repair during antibody diversification.

Jan 12    FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.

Dec 1    An in vitro system to silence mitochondrial gene expression.

Dec 1    In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target.

Nov 17  Antigen dominance hierarchies shape TCF1 +progenitor CD8 T cell phenotypes in tumors.  

Nov 17  Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment.

Nov 10  Transmission of trained immunity and heterologous resistance to infections across generations.

Nov 10  Maternal gut microbiome regulates immunity to RSV infection in offspring.

Oct 27   Lrp1 is a host entry factor for Rift Valley fever virus.

Oct 27   Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species.

Oct 20   The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function.

Oct 20   Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer.

Oct 13   Polyamine metabolism is a central determinant of helper T cell lineage fidelity.  

Oct 13   Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.

Sep 29   A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells.      

Sep 29   Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.

Sep 22   High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide.

Sep 22   Dietary fructose improves intestinal cell survival and nutrient absorption.

Sep 15  Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring.

Sep 15   Thymic development of gut-microbiota-specific T cells.  

May 26    Follicular regulatory T cells produce neuritin to regulate B cells.

May 26    Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.   

May 19   Discovery and functional interrogation of SARS-CoV- 2 RNA-host protein interactions.

May 19   The spatial landscape of lung pathology during COVID-19 progression.

May 12  Identification of bacteria-derived HLA-bound peptides in melanoma.

May 12  Macrophages provide a transient muscle stem cell niche via NAMPT secretion.

May 5    Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.

May 5    NASH limits anti-tumour surveillance in immunotherapy-treated HCC.

Apr 28   NINJ1 mediates plasma membrane rupture during lytic cell death.

Apr 28:   Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance.

Apr 21   The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.

Apr 21   Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.

Apr 14   Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis.

Apr 14    gd T cells regulate the intestinal response to nutrient sensing.

Apr 7      Commensal Microbiota Modulation of Natural Resistance to Virus Infection.

Apr 7     Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice.

Mar 31   Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

Mar 31   CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours.

Mar 24   mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.

Mar 24   Prospective mapping of viral mutations that escape antibodies used to treat COVID-19.

Mar 10   Restoring metabolism of myeloid cells reverses cognitive decline in ageing.  

Mar 10   Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential. 

Mar 3    Infection trains the host for microbiota-enhanced resistance to pathogens.

Mar 3   A basophil-neuronal axis promotes itch.

Feb 24   The Identity of Human Tissue-Emigrant CD8+T Cells.

Feb 24  A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis .

Feb 17   STING controls nociception via type I interferon signalling in sensory neurons.

Feb 17   m6A RNA methylation regulates the fate of endogenous retroviruses.

Feb 10   Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE.  

Feb 10   Local immune response to food antigens drives meal-induced abdominal pain.

Feb 3    Anti-tumor immunity induces aberrant peptide presentation in melanoma.

Feb 3    HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.

Jan 27   Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation.

Jan 27   Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.

Jan 20   Macrophage-derived glutamine boosts satellite cells and muscle regeneration.

Jan 20   Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function.

Jan 13   The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.

Jan 13   Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).

Dec 2     SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition.

Dec 2     Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.

Nov 18   Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. 

Nov 18   The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids. 

Nov 11   A Phase Ib Trial of Personalized Neoantigen TherapyPlus Anti-PD-1 in Patients with Advanced Melanoma,Non-small Cell Lung Cancer, or     Bladder Cancer. 

Nov 11   Noninvasive Early Identification of TherapeuticBenefit from Immune Checkpoint Inhibition.  

Nov 4     Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.

Nov 4     Immune-evasive human islet-like organoids ameliorate diabetes.

Oct 28   Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.  

Oct 28   Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.  

Oct 21    Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.

Oct 21   Succination inactivates gasdermin D and blocks pyroptosis. 

Oct 14   Sex-specific adipose tissue imprinting of regulatory T cells.

Oct 14   The impact of sex on gene expression across human tissues.  

Oct 7     IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.

Oct 7    TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.

Sep 30   Fibroblasts as a source of self-antigens for central immune tolerance.

Sep 30  Gut microorganisms act together to exacerbate inflammation in spinal cords.

Sep 23.  Interleukin-13 drives metabolic conditioning of muscle to endurance exercise.

Sep 23   A neurotransmitter produced by gut bacteria modulates host sensory behaviour.

Sep 16   Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.

Sep 16   Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage.

Sep 9      The human tumor microbiome is composed of tumor type-specific intracellular bacteria.  

Sep 9      RNA sensing by Gut Piezo1 is essential for systemic serotonin synthesis.

Jun 1    Caspase-6 is a Key Regulator of Innate Immunity, Inflammasome Activation, and Hose Defense. : Caspase 6 in ZBP1-mediated cell death.

Jun 1    Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. : Engineering cells for immune therapies.

May 27   Sex-specific adipose tissue imprinting of regulatory T cells. : Sex hormones control T regs in fat tissues.

May 27   Organ-specific isoform selection of fatty acid-binding proteins in tissue-residentlymphocytes. : Fatty acid-binding proteins on tissue-resident T cells.

May 13    Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids. : Long-term effect of Glucocorticoids on CD8 T cells.

May 13    γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis. : γδ T cells on nerve innervation and thermogenesis.

May 6     Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. : Genotoxic E.coli directly cause mutations in cancer. 

May 6     AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment. :  DNA damage-mediated AIM2 activation and pyroptosis shape neurodevelopment.

May 6     Gut stem cell necroptosis by genome instability triggers bowel inflammation. : SETDB1 suppresses endogenous ligand expression to prevent ZBP-1 activation and inflammation.

Apr 22    Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. : DCs control iron homeostasis and mucosal healing through hepcidin. 

Apr 22    Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. : Endogenous ligand-mediated ZBP-1 activation and necroptosis.

Apr 22    Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. : Recognition of viral Z-RNAs by ZBP-1. 

Apr 15.    SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. : Cell entry by SARS-CoV-2. 

Apr 15    Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. : Pre-existing antibody against anti-spike proteins of SARS-CoV causes lung injury.

Apr 8    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. : Inhibition of endocytosis for antibody-mediated cancer therapy. 

Apr 8    Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody. : Lymphoma signatures on autoimmune B cells.

Apr 1    Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. : The effect of Ketogenic diet on gd T cells. 

Apr 1     Ketogenic diet activates protective γδ T cell responses against influenza virus infection. : The effect of Ketogenic diet on gd T cells.

Mar 25    Global chemical effects of the microbiome include new bile-acid conjugations. : New bile acid conjugations by microbiome. 

Mar 25.    A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. : The role of Glucosinolate metabolites. 

Mar 18     ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. : The role of ILC2 during PD-1 checkpoint therapy.

Mar 18     CRISPR-engineered T cells in patients with refractory cancer.: CRISPR engineering of T cells.

Mar 11    IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. : New mouse model for coeliac disease.  

Mar 11    TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise. : TLR9 and exercise-induced metabolic responses.

Mar 4      An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. : Cell death in nonalcoholic liver disease.

Mar 4     Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. : Phage therapy for alcoholic liver disease.

Feb 26    Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells. : Ligand binding of gd T cells.

Feb 26     T cell-derived interferon-gamma programs stem cell death in immune-mediated intestinal damage. : Stem cell destruction by immune responses.

Feb 19     Microbial bile acid metabolites modulate gut RORgamma+ regulatory T cell homeostasis. : Effect of bile acid metabolites on T cell differentiation.

Feb 19     Bile acid metabolites control Th17 and Treg cell differentiation. Hang et al. : Effect of bile acid metabolites on T cell differentiation.

Feb 12     Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. : Hair stem cell depletion by nerve activation.

Feb 12     VISTA is a checkpoint regulator for naive T cell quiescece and peripheral tolerance. : Checkpoint regulator for quiescence.

Feb 5      Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease. : CD8 T cells and Alzheimer's disease.

Feb 5     Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. : Microbial peptide mimics and Cardiomyopathy.

Jan 22    Gut-innervating nociceptor neurons regulate peyer's patch microfold cells and SFB levels to mediate Salmonella host defense. : TRPV1+ neurons on immune responses in the gut.

Jan 22   Enteric nervous system-derived IL-18 orchestrates mucosal barrier immunity. : Cytokine production by neurons.

Jan 15    Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. : Host monitoring of quorum sensing of microbes.

Jan 15    Depletion of microbiome-derived molecules in the host using Clostridium genetics : Studying microbial metabolites.

Dec 11   Release from UNC93B1 reinforces the compartmentalized activation of select TLRs. : Compartmentalized activation of TLRs.

Dec 11   UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. : TLR signaling and threshold for autoimmunity.

Dec 4   MHC-II neoantigens shape tumour immunity and response to immunotherapy. : CD4 T cells in immunotherapy.

Dec 4    VISTA is an acidic pH-selective ligand for PSGL-1. : A new kind of inhibitory receptor, VISTA.

Nov 20  Microbial metabolites control the thymic development of mucosal-associated invariant T cells. : Microbial metaboites control thymic development of MAIT T cells.

Nov 20  MAIT cells are imprinted by the microbiota in early life and promote tissue repair. : MAIT cell imprinting early in life.

Nov 13  Search-and-replace genome editing without double-strand breaks or donor DNA. : CAS9-mediated, low-risk DNA editing.

Nov 13  CRISPR-mediated live imaging of genome editing and transcription. : CRISPR-mediated live imaging.

Nov 6   FSP1 is a glutathione-independent ferroptosis suppressor. : FSP1 regulates Ferroptosis.

Nov 6   Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. : RIPK1 regulates apoptosis and necroptosis.

Oct 30   Interspecies competition impacts targeted manipulation of human gut bacteria by fiber-derived glycans. : Manipulating microbiota by dietary fibers.

Oct 30   Engineering phage host-range and suppressing bacterial resistance through phage tail fiber mutagenesis. : Manipulating bacteria by engineered phage.

Oct 23   Antibiotics-driven gut microbiome perturbation alters immunity to vaccines in humans. : The effect of microbiota on vaccination.

Oct 23   Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming.: Hepatocyte-mediated priming of CD8 T cells.

Oct 16   Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis. : Circadian circuit regulat ILC3.

Oct 16   The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3. : Micrbiota programs circadian rhythm through HDAC3.

Oct 9   The bone marrow protects and optimizes immunological memory during dietary restriction. : Dietary restriction and T cell memory in the bone marrow.

Oct 9   Dietary intake regulates the circulating inflammatory monocyte pool. : Dietary restriction and inflammatory monocytes.

Oct 2   N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. : Host metabolism inhibits viral infection.

Oct 2   Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. : Off-target toxicity of most cancer drugs.

Sep 25  Opposing T cell responses in experimental autoimmune encephalomyelitis. : Regulatory CD8T cells?

Sep 25   Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. : New sensor for DNA viruses.

Sep 18  Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor. : CAR T cell therapy for solid tumors

Sep 18   T cell-mediated regulation of the microbiota protects against obesity. : T cell-Microbiota-Obesity.

Sep 11   Cutaneous TRPV1+ neurons trigger protective innate type 17 anticipatory immunity. :  Th17 cells generate tissue resident memory.

Sep 11   Effector Th17 cells give rise to long-lived TRM cells that are essential for an immediate response against bacterial infection. : TRPV1+ neurns initiate Th17 responses.