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Research
Research

Aplin Research

Contact

Andrew Aplin, PhD
  • Deputy Director, Sidney Kimmel Comprehensive Cancer Center
  • Kalbach-Newton Professor in Cancer Research
Department of Pharmacology, Physiology & Cancer Biology

233 S 10th Street
BLSB 1050
Philadelphia, PA 19107

Publications

Recent Publications

SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models

Inhibition of anti-apoptotic BCL2 overcomes adaptive resistance to co-targeting of the protein kinase FAK and MEK in GNAQ-driven uveal melanoma

Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells

Correction: Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma (Cancer Res (2019) 79 (2415-25) DOI: 10.1158/0008-5472.CAN-18-3177)

Facts and Hopes: Toward the Next Quantum Leap in Melanoma

Metabolic Inhibition Induces Pyroptosis in Uveal Melanoma

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma

Meeting Report From the 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Philadelphia, PA, November 2023

Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma

SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death

Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress

Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

Targeting TEAD-ious resistance

Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping

Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma

Site matters in metastatic melanoma

Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth

Lysosomal lipid peroxidation regulates tumor immunity

Engaging community members in cancer research: an assessment of an NCI-designated cancer center

IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression

Raptinal Induces Gasdermin E-Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma

Publications

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