Rahman Research
CONTACT
Jefferson Alumni Hall, 562E (Office)
Jefferson Alumni Hall, 565 (Lab)
Philadelphia, PA 19107
Highlighted Publications
Fike AJ, Bricker KN, Gonzalez MV, Maharjan A, Bui T, Nuon K, Emrich SM, Weber JL, Luckenbill SA, Choi NM, Sauteraud R, Liu DJ, Olsen NJ, Caricchio R, Trebak M, Chodisetti SB, Rahman ZSM. IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints. J Exp Med. 2025 Jul 7;222(7). doi: 10.1084/jem.20231882. Epub 2025 May 27. PubMed PMID: 40439584; PubMed Central PMCID: PMC12121627.
Fike AJ, Chodisetti SB, Wright NE, Bricker KN, Domeier PP, Maienschein-Cline M, Rosenfeld AM, Luckenbill SA, Weber JL, Choi NM, Luning Prak ET, Mandal M, Clark MR, Rahman ZS. STAT3 signaling in B cells controls germinal center zone organization and recycling. Cell Rep. 2023 May 30;42(5):112512. PMID: 37200190.
Domeier PD, Chodisetti SB, Soni C*, Schell SL, Elias MJ, Wong EB, Cooper T, Kitamura D, and Rahman ZS. Interferon-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J. Exp. Med, e-published ahead of print, April 11, 2016, doi:10.1084/jem.20151722. PMCID: PMC4854731 (* Equal second authorship).
Domeier PP, Chodisetti SB, Schell SL, Kawasawa YI, Fasnacht MJ, Soni C, Rahman ZSM. B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells. Cell Rep. 2018 Jul 10; 24(2):406-418. PMCID: PMC6089613.
Schell SL, Bricker KN, Fike AJ, Chodisetti SB, Domeier PP, Choi NM, Fasnacht MJ, Sara A. Luckenbill SA, Ziegler SF, and Rahman ZS. Context-dependent miR-21 regulation of TLR7-mediated autoimmune and foreign antigen driven antibody-forming cell and germinal center responses. J Immunol. 2021 May 26:ji2001039. doi: 10.4049/jimmunol.2001039. PMID: 34039637.
Publications
- IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
- STAT3 signaling in B cells controls germinal center zone organization and recycling
- Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
- B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling
- The mitochondrial sodium/calcium exchanger NCLX (Slc8b1) in B lymphocytes
- Regulation of B cell responses in sle by three classes of interferons
- The cyclin-dependent kinase 8 (CDK8) inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway
- New developments implicating IL-21 in autoimmune disease
- Context-dependent mir-21 regulation of tlr7-mediated autoimmune and foreign antigen-driven antibody-forming cell and germinal center responses
- miRNA-Mediated Control of B Cell Responses in Immunity and SLE
- STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus–like Autoimmune- And Foreign Antigen–Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses
- IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
- TLR7 Negatively Regulates B10 Cells Predominantly in an IFNγ Signaling Dependent Manner
- Serine phosphorylation of the STAT1 transactivation domain promotes autoreactive B cell and systemic autoimmunity development
- Type II but not type I IFN signaling is indispensable for TLR7-promoted development of autoreactive B cells and systemic autoimmunity
- Crispr-cas replacing antiviral drugs against hiv: An update
- Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ
- Strain-Dependent Contribution of MAVS to Spontaneous Germinal Center Responses
- Selenium supplementation suppresses immunological and serological features of lupus in B6.Sle1b mice
- The Post-GWAS Era: How to Validate the Contribution of Gene Variants in Lupus