Publications

Wu Research

Contact

Chengyuan Wu, MD, MSBmE

Associate Professor, Neurological Surgery & Radiology

Jefferson Integrated Magnetic Resonance Imaging Center

909 Walnut Street
1st Floor
Philadelphia, PA 19107

Chengyuan.Wu@jefferson.edu

215-503-5560

Twitter

Highlighted Publications

Movement Disorders

Fayed, I., Syed, M., Gingold, E., Alizadeh, M., Sharan, A., & Wu, C. (2023). A Novel and Simple Method Using Computed Tomography Streak Artifact to Determine the Orientation of Directional Deep Brain Stimulation Leads. Neurosurgery, 10.1227/neu.0000000000002536. Advance online publication. https://doi.org/10.1227/neu.0000000000002536

Vedaei, F., Fayed, I., Alizadeh, M., Miller, C., Zhang, A. B., Koa, V., Khan, S., Mohamed, F. B., & Wu, C. (2023). Effect of Enlarged Perivascular Spaces in Reliable Distinction of Prospective Targeting During Deep Brain Stimulation in Patients With Advanced Parkinson's Disease: A Study of Deterministic and Probabilistic Tractography. Neurosurgery, 93(3), 691–698. https://doi.org/10.1227/neu.0000000000002478

Miao, J., Tantawi, M., Koa, V., Zhang, A. B., Zhang, V., Sharan, A., Wu, C., & Matias, C. M. (2022). Use of Functional MRI in Deep Brain Stimulation in Parkinson's Diseases: A Systematic Review. Frontiers in neurology, 13, 849918. https://doi.org/10.3389/fneur.2022.849918

Wu, C., Nagel, S. J., Agarwal, R., Pötter-Nerger, M., Hamel, W., Sharan, A. D., Connolly, A. T., Cheeran, B., & Larson, P. S. (2021). Reduced Risk of Reoperations With Modern Deep Brain Stimulator Systems: Big Data Analysis From a United States Claims Database. Frontiers in neurology, 12, 785280. https://doi.org/10.3389/fneur.2021.785280

Wu, C., Matias, C., Foltynie, T., Limousin, P., Zrinzo, L., & Akram, H. (2021). Dynamic Network Connectivity Reveals Markers of Response to Deep Brain Stimulation in Parkinson's Disease. Frontiers in human neuroscience, 15, 729677. https://doi.org/10.3389/fnhum.2021.729677

Muller, J., Alizadeh, M., Li, L., Thalheimer, S., Matias, C., Tantawi, M., Miao, J., Silverman, M., Zhang, V., Yun, G., Romo, V., Mohamed, F. B., & Wu, C. (2020). Feasibility of diffusion and probabilistic white matter analysis in patients implanted with a deep brain stimulator. NeuroImage. Clinical, 25, 102135. https://doi.org/10.1016/j.nicl.2019.102135

Wu, C., Matias, C. (2019). Commentary: Using Directional Deep Brain Stimulation to Co-activate the Subthalamic Nucleus and Zona Incerta for Overlapping Essential Tremor/Parkinson's Disease Symptoms. Front Neurol . 2019 Sep 6;10:854. [PMID:31555192]

Muller, J., Alizadeh, M., Mohamed, F. B., Riley, J., Pearce, J. J., Trieu, B., Liang, T. W., Romo, V., Sharan, A., & Wu, C. (2018). Clinically applicable delineation of the pallidal sensorimotor region in patients with advanced Parkinson's disease: study of probabilistic and deterministic tractography. Journal of neurosurgery, 1–12. Advance online publication. https://doi.org/10.3171/2018.7.JNS18541

Akram, H., Wu, C., Hyam, J., Foltynie, T., Limousin, P., De Vita, E., Yousry, T., Jahanshahi, M., Hariz, M., Behrens, T., Ashburner, J., & Zrinzo, L. (2017). l-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 32(6), 874–883. https://doi.org/10.1002/mds.27017

Epilepsy

Sathe, A. V., Matias, C. M., Kogan, M., Ailes, I., Syed, M., Kang, K., Miao, J., Talekar, K., Faro, S., Mohamed, F. B., Tracy, J., Sharan, A., & Alizadeh, M. (2023). Resting-State fMRI Can Detect Alterations in Seizure Onset and Spread Regions in Patients with Non-Lesional Epilepsy: A Pilot Study. Frontiers in neuroimaging, 2, 1109546. https://doi.org/10.3389/fnimg.2023.1109546

Manmatharayan, A., Kogan, M., Matias, C., Syed, M., Shelley, I., Chinni, A., Kang, K., Talekar, K., Faro, S.H., Mohamed, F.B., Sharan, A., Wu, C., Alizadeh, M. (2023). Automated subfield volumetric analysis of amygdala, hippocampus, and thalamic nuclei in mesial temporal lobe epilepsy. World Neurosurgery: X, 19. https://doi.org/10.1016/j.wnsx.2023.100212.

Sathe, A. V., Kogan, M., Kang, K., Miao, J., Syed, M., Ailes, I., Matias, C. M., Middleton, D., Mohamed, F. B., Faro, S., Tracy, J., Sharan, A., & Alizadeh, M. (2022). Amplitude synchronization of spontaneous activity of medial and lateral temporal gyri reveals altered thalamic connectivity in patients with temporal lobe epilepsy. Scientific reports, 12(1), 18389. https://doi.org/10.1038/s41598-022-23297-4

Hines, K., Stefanelli, A., Haddad, T., Matias, C. M., Sharan, A., & Wu, C. (2022). Costs Associated with Laser Interstitial Thermal Therapy Are Lower Than Anterior Temporal Lobectomy for Treatment of Temporal Lobe Epilepsy. World neurosurgery, 157, e215–e222. https://doi.org/10.1016/j.wneu.2021.09.144

Vakharia, V. N., Sparks, R. E., Li, K., O'Keeffe, A. G., Pérez-García, F., França, L. G. S., Ko, A. L., Wu, C., Aronson, J. P., Youngerman, B. E., Sharan, A., McKhann, G., 2nd, Ourselin, S., & Duncan, J. S. (2019). Multicenter validation of automated trajectories for selective laser amygdalohippocampectomy. Epilepsia, 60(9), 1949–1959. https://doi.org/10.1111/epi.16307

Wu, C., Jermakowicz, W. J., Chakravorti, S., Cajigas, I., Sharan, A. D., Jagid, J. R., Matias, C. M., Sperling, M. R., Buckley, R., Ko, A., Ojemann, J. G., Miller, J. W., Youngerman, B., Sheth, S. A., McKhann, G. M., Laxton, A. W., Couture, D. E., Popli, G. S., Smith, A., Mehta, A. D., … D'Haese, P. F. (2019). Effects of surgical targeting in laser interstitial thermal therapy for mesial temporal lobe epilepsy: A multicenter study of 234 patients. Epilepsia, 60(6), 1171–1183. https://doi.org/10.1111/epi.15565

Galovic, M., Baudracco, I., Wright-Goff, E., Pillajo, G., Nachev, P., Wandschneider, B., Woermann, F., Thompson, P., Baxendale, S., McEvoy, A. W., Nowell, M., Mancini, M., Vos, S. B., Winston, G. P., Sparks, R., Prados, F., Miserocchi, A., de Tisi, J., Van Graan, L. A., Rodionov, R., … Koepp, M. J. (2019). Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy. JAMA neurology, 76(6), 690–700. https://doi.org/10.1001/jamaneurol.2019.0204

Vakharia, V. N., Sparks, R., Li, K., O'Keeffe, A. G., Miserocchi, A., McEvoy, A. W., Sperling, M. R., Sharan, A., Ourselin, S., Duncan, J. S., & Wu, C. (2018). Automated trajectory planning for laser interstitial thermal therapy in mesial temporal lobe epilepsy. Epilepsia, 59(4), 814–824. https://doi.org/10.1111/epi.14034

Wu, C., D'Haese, P. F., Pallavaram, S., Dawant, B. M., Konrad, P., & Sharan, A. D. (2016). Variations in Thalamic Anatomy Affect Targeting in Deep Brain Stimulation for Epilepsy. Stereotactic and functional neurosurgery, 94(6), 387–396. https://doi.org/10.1159/000449009

Kang, J. Y., Wu, C., Tracy, J., Lorenzo, M., Evans, J., Nei, M., Skidmore, C., Mintzer, S., Sharan, A. D., & Sperling, M. R. (2016). Laser interstitial thermal therapy for medically intractable mesial temporal lobe epilepsy. Epilepsia, 57(2), 325–334. https://doi.org/10.1111/epi.13284

Wu, C., Boorman, D. W., Gorniak, R., Farrell, C., Evans, J. J., Sharan, A. D. (2015) The Effects of Anatomic Variations on Stereotactic Laser Amygdalohippocampectomy and a Proposed Protocol for Trajectory Planning. Neurosurgery 11(2):p 345-357, June 2015, DOI: 10.1227/NEU.0000000000000767

Wu, C., LaRiviere, M. J., Laxpati, N., Evans, J. J., Gross, R. E., & Sharan, A. D. (2014). Extraventricular long-axis cannulation of the hippocampus: technical considerations. Neurosurgery, 10 Suppl 2(0 2), 325–333. https://doi.org/10.1227/NEU.0000000000000320

Wu, C., Sperling, M. R., Falowski, S. M., Chitale, A. V., Werner-Wasik, M., Evans, J. J., Andrews, D. W., & Sharan, A. D. (2012). Radiosurgery for the treatment of dominant hemisphere periventricular heterotopia and intractable epilepsy in a series of three patients. Epilepsy & behavior case reports, 1, 1–6. https://doi.org/10.1016/j.ebcr.2012.10.004

Wu, C., Evans, J. J., Skidmore, C., Sperling, M. R., & Sharan, A. D. (2013). Impedance variations over time for a closed-loop neurostimulation device: early experience with chronically implanted electrodes. Neuromodulation : journal of the International Neuromodulation Society, 16(1), 46–50. https://doi.org/10.1111/j.1525-1403.2012.00529.x

MR Imaging

Mandloi, S., Syed, M., Shoraka, O., Ailes, I., Kang, K. C., Sathe, A., Heller, J., Thalheimer, S., Mohamed, F. B., Sharan, A., Harrop, J., Krisa, L., Matias, C., & Alizadeh, M. (2023). The role of the insula in chronic pain following spinal cord injury: A resting-state fMRI study. Journal of neuroimaging : official journal of the American Society of Neuroimaging, https://doi.org/10.1111/jon.13117

Vedaei, F., Mashhadi, N., Zabrecky, G., Monti, D., Navarreto, E., Hriso, C., Wintering, N., Newberg, A.B., Mohamed, F.B. (2023). Identification of Chronic Mild Traumatic Brain Injury Using Resting State Functional MRI and Machine Learning Techniques. Frontiers in Neuroscience 16 (2023). https://doi.org/10.3389/fnins.2022.1099560.

Muller, J., Wang, R., Milddleton, D., Alizadeh, M., Kang, K.C., Hryczyk, R., Zabrecky, G., Hriso, C., Navarreto, E., Wintering, N., Bazzan, A.J., Wu C., MontI, D.A., Jiao, X., Wu, Q., Newberg, A.B., Mohamed, F.B. (2023). Machine learning-based classification of chronic traumatic brain injury using hybrid diffusion imaging. Frontiers in Neuroscience, 17 https://doi.org/10.3389/fnins.2023.1182509

Vedaei, F., Alizadeh, M., Tantawi, M., Romo, V., Mohamed, F. B., & Wu, C. (2023). Vascular and neuronal effects of general anesthesia on the brain: An fMRI study. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 33(1), 109–120. https://doi.org/10.1111/jon.13049

Miao, J., Ailes, I., Krisa, L., Fleming, K., Middleton, D., Talekar, K., Natale, P., Mohamed, F. B., Hines, K., Matias, C. M., & Alizadeh, M. (2022). Case report: The promising application of dynamic functional connectivity analysis on an individual with failed back surgery syndrome. Frontiers in neuroscience, 16, 987223. https://doi.org/10.3389/fnins.2022.987223

Vedaei, F., Alizadeh, M., Romo, V., Mohamed, F. B., & Wu, C. (2022). The effect of general anesthesia on the test-retest reliability of resting-state fMRI metrics and optimization of scan length. Frontiers in neuroscience, 16, 937172. https://doi.org/10.3389/fnins.2022.937172

Wu, C., Ferreira, F., Fox, M., Harel, N., Hattangadi-Gluth, J., Horn, A., Jbabdi, S., Kahan, J., Oswal, A., Sheth, S. A., Tie, Y., Vakharia, V., Zrinzo, L., & Akram, H. (2021). Clinical applications of magnetic resonance imaging based functional and structural connectivity. NeuroImage, 244, 118649. https://doi.org/10.1016/j.neuroimage.2021.118649