Summer Research
Ross Summer, MD

Contact

Name: Ross Summer, MD
Position: Professor

1020 Locust Street
Room 368
Philadelphia, PA 19107

Telephone: 215-503-3893

Highlighted Publications

Steplewski, A., Fertala, J., Arita, M., Romero, F., Summer, R., Fertala, R. Target-Specific Delivery of an Antibody That Blocks the Formation of Fibrotic Deposits in Keloid and Lung Fibrosis Models, Monoclon Antib Immunodiagn Immunother. [201728972447]

This study demonstrates our ability to deliver a novel antifibrotic antibody to the lung and provides preliminary evidence that this biologic may be effective in the treatment of pulmonary fibrosis.

Freddy Romero, Xu Hong, Dilip Shah, Caleb B. Kallen, Ivan Rosas, Zhi Guo, DeLeila Schriner, Julie Barta, Hoora Shaghaghi, Jan B. Hoek, Clementina Mesaros, Augustine M. Choi, Nathaniel W. Snyder, and Ross SummerLipid synthesis is required to resolve ER stress and limit fibrotic responses in the lung Am J Respir Cell Mol Biol. 2018.

This study provides a unifying mechanism linking ER stress to the development of pulmonary fibrosis. We show that metabolic dysfunction, namely the impairment of lipid synthesis, reduces the capacity of alveolar epithelial cells to resolve ER stress, leading to sustained cellular dysfunction and induction of fibrotic responses. We also provide evidence that pharmacological or dietary approaches to increasing lung lipids could be effective in treating pulmonary fibrosis.

Shah, D., Romero, R., Duong, M., Wang, N., Paudyal, B., Suratt, B., Kallen, C.B., Sun, J., Walsh, K., Summer., R. Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury. Sci Rep. 2015 Jun 12;5:11362. PMID: 26068229.

This study uncovers a novel mechanism that appears to explain why obesity predisposes patients to developing ARDS, and in the process, might have discovered a novel strategy for preventing ARDS in obese individuals.

Romero F, Shah D, Duong M, Penn RB, Fessler MB, Madenspacher J, Stafstrom W, Kavuru M, Lu B, Kallen CB, Walsh K, Summer R. A Pneumocyte-macrophage Paracrine Lipid Axis Drives the Lung Toward Fibrosis. Am J Respir Cell Mol Biol. 2014 Nov 19. E-pub ahead of print [PMID:25409201].

This study is the first to suggest that macrophage foam cells play a causal role in the development of pulmonary fibrosis and that strategies aimed at blocking their formation might be effective in limiting the onset and progression of disease.

Romero, F., Shah, D., Duong, M., Stafstrom, W., Hoek, JB., Kallen, CB., Lang, CH. , Summer, R. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation and impairs alveolar macrophage functions.  Am J Respir Cell Mol Biol 2014 Jun 8 [PMID: 24940828].

This work demonstrates that chronic alcohol exposure induces significant metabolic changes in the lung, including marked accumulation of triglycerides and free fatty acids within distal airspaces and alveolar macrophages (AMs). Furthermore, this study provides evidence linking these lipid abnormalities to phenotypic and functional impairments in AMs, suggesting that metabolic disturbances may be contributing to the pathogenesis of alcohol-related inflammatory lung diseases.

Recent Publications

Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung

Tocilizumab in the Management of COVID-19: A Preliminary Report

Acute Exacerbation of Interstitial Lung Disease as a Sequela of COVID-19 Pneumonia

On Race and the Environment in the COVID-19 Pandemic

COVID-19 Retesting in the Primary Care Setting

Retraction: Obesity-induced endoplasmic reticulum stress causes lung endothelial dysfunction and promotes acute lung injury

A Comprehensive Review of Manifestations of Novel Coronaviruses in the Context of Deadly COVID-19 Global Pandemic

E-cigarettes and Vaping Associated Lung Injury: A Case Series and Brief Review

Alcohol-induced lipid dysregulation impairs glycolytic responses to LPS in alveolar macrophages

Maxed out on glycolysis: Alveolar macrophages rely on oxidative phosphorylation for cytokine production

Pulmonary circulation in obesity, diabetes, and metabolic syndrome

The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase

Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust

The involvement of GM-CSF deficiencies in parallel pathways of pulmonary alveolar proteinosis and the alcoholic lung

Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome

Time to personalize the treatment of anti-MDA-5 associated lung disease

Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium

Metabolic Reprogramming as a Driver of Fibroblast Activation in PulmonaryFibrosis

Proteomic profile of TGF-β1 treated lung fibroblasts identifies novel markers of activated fibroblasts in the silica exposed rat lung

Cellular Metabolism in Lung Health and Disease

Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis

Lipid metabolism: A new player in the conundrum of lung fibrosis

Activated fibroblasts: Gluttonous for glutamine

Combination of biochanin a and temozolomide impairs tumor growth by modulating cell metabolism in glioblastoma multiforme

Nur77 limits endothelial barrier disruption to LPS in the mouse lung