Smeyne Research
Contact
Name:
Richard Jay Smeyne, PhD
Position:
- Professor and Chair, Department of Neuroscience
- Director, Jefferson Comprehensive Parkinson's Disease and Movement Disorder Center
- Vickie & Jack Farber Institute for Neuroscience
Organization:
Jefferson Hospital for Neuroscience
900 Walnut Street
4th Floor
Philadelphia, PA 19107
Email:
Richard.Smeyne@jefferson.edu
Contact Number(s):
Our Most Cited Papers Related to Parkinson's Disease
- Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. H Jang, D Boltz, K Sturm-Ramirez, KR Shepherd, Y Jiao, R Webster, RJ Smeyne, Proceedings of the National Academy of Sciences 106 (33), 14063-14068
- Glutathione metabolism and Parkinson's disease. M Smeyne, RJ Smeyne. Free Radical Biology and Medicine 62, 13-25
- The MPTP model of Parkinson's disease. RJ Smeyne, V Jackson-Lewis. Molecular brain research 134 (1), 57-66
- Viral parkinsonism. H Jang, DA Boltz, RG Webster, RJ Smeyne. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1792 (7), 714-721
- Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes. YM Kuo, Z Li, Y Jiao, N Gaborit, AK Pani, BM Orrison, BG Bruneau, BI Giasson, RJ Smeyne, MD Gershon, RL Nussbaum. Human molecular genetics 19 (9), 1633-1650
- Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. CJ Faherty, KR Shepherd, A Herasimtschuk, RJ Smeyne. Molecular brain research 134 (1), 170-179
- COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside. D Sulzer, A Antonini, V Leta, A Nordvig, RJ Smeyne, JE Goldman, O Al-Dalahmah, L Zecca, A Sette, L Bubacco, O Meucci, E Moro, AS Harms, Y Xu, S Fahn, KR Chaudhuri. npj Parkinson's Disease 6 (1), 18
- Exercise: is it a neuroprotective and if so, how does it work? MJ Zigmond, RJ Smeyne. Parkinsonism & related disorders 20, S123-S127
- A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse. ZC Baquet, D Williams, J Brody, RJ Smeyne. Neuroscience 161 (4), 1082-1090
- Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo. E Kozina, S Sadasivan, Y Jiao, Y Dou, Z Ma, H Tan, K Kodali, T Shaw, J Peng, RJ Smeyne Brain 141 (6), 1753-1769
Publications
- Exposure to manganese during juvenile development increases microglial activation in the hippocampus following systemic infection with A/California/04/2009 Influenza A H1N1 virus
- Persistent microglial activation following neonatal CMV infection mediates neurodegeneration
- Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
- Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy
- GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
- Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease
- Neuroanatomical and neurochemical effects of prolonged social isolation in adult mice
- Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease
- Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
- COVID-19 Infection Enhances Susceptibility to Oxidative Stress–Induced Parkinsonism
- Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice
- The impact of isolation on brain health
- Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis
- Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism
- Infection and risk of Parkinson's disease
- Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus
- COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
- Synaptic alterations and immune response are sexually dimorphic in a non-pertussis toxin model of experimental autoimmune encephalomyelitis
- Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation
- Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin