Scott Research
CONTACT
233 South 10th Street
833 BLSB
Philadelphia, PA 19107
Highlighted Publications
McDuffie, E., Panettieri, R., Scott, C. P. “G12/13 Signaling in Asthma.” Respiratory Research 25 (1): 295 (2024). doi: 10.1186/s12931-024-02920-0.
Ippolito, M., De Pascali, F. Hopfinger, N., Komolov, K. E., Larinavichyute, D., Reddy, P. A. N., Sakkal, L. A., Rajkowski, K. Z., Nayak, A. P., Lee, J., Lee, J., Cao, G., Donover, P. S., Reichman, M., An, S. S., Salvino, J. M., Penn, R. B., Armen, R. S., Scott, C. P., Benovic, J. L. "Identification of a beta-arrestin-biased allosteric modulator of the beta-2-adrenergic receptor." Proceedings of the National Academy of Sciences, USA (2023) 120 (31):e2302668120. PMC10401000
De Pascali, F., Ippolito, M., Wolfe, E., Komolov, K. E., Hopfinger, N., Lemenze, D., Kim, N., Armen, R. S., Am, S. S., Scott, C. P., Benovic, J. L. "Beta-2-Adrenoreceptor agonist profiling reveals biased signalling phenotypes for the beta-2-adrenoreceptor with possible implications for the treatment of asthma." British J. Pharmacol. (2022) 1-17. PMC9474705
Xiong, L., Scott, C. P. (2014) “Bioprospecting open reading frames for peptide effectors” Methods in Molecular Biology 1088: 81 – 96 (2014). PMID: 24148398
Juliana, C., Fernandez-Alnemri, T., Wu, J., Datta, P., Solorzano, L., Yu, J-W., Meng, R., Quong, A. A., Latz, E., Scott, C. P., Alnemri, E. S. “Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.” J. Biol. Chem. 285 (13), 9792 – 802 (2010). PMC2843228
Scott, C. P., Abel-Santos, E., Wall, M., Wahnon, D. C., Benkovic, S. J. (1999) "The production of cyclic peptides and proteins in vivo." Proceedings of the National Academy of Sciences (USA) 96 (24), 13638-43. PMC24117
Publications
- Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to reactive oxygen species-induced cell death
- Correction to: G12/13 signaling in asthma (Respiratory Research, (2024), 25, 1, (295), 10.1186/s12931-024-02920-0)
- G12/13 signaling in asthma
- Identification of a β-arrestin-biased negative allosteric modulator for the β2-adrenergic receptor
- β2-Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2-adrenoceptor with possible implications for the treatment of asthma
- Mycobacterium tuberculosis type II NADH-menaquinone oxidoreductase catalyzes electron transfer through a two-site ping-pong mechanism and has two quinone-binding sites
- Bioprospecting open reading frames for peptide effectors
- Anti-inflammatory compounds parthenolide and bay 11-7082 are direct inhibitors of the inflammasome
- Taking the chemical out of chemical genetics
- Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Eμ-TCL1 transgenic mice
- Use of inteins for the in vivo production of stable cyclic peptide libraries in E. coli.
- A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit
- Structural requirements for the biosynthesis of backbone cyclic peptide libraries
- A quantitative model for allosteric control of purine reduction by murine ribonucleotide reductase
- Production of cyclic peptides and proteins in vivo
- High level expression of the large subunit of mouse ribonucleotide reductase in a baculovirus system