Schnell Research

Contact

Positions:
  • Chair, Department of Microbiology & Immunology
  • Dr. V. Watson Pugh & Frances Plimpton Pugh Professor in Microbiology & Immunology
Position: Sidney Kimmel Medical College

233 South Tenth Street
BLSB-531
Philadelphia, PA 19107

Contact Number(s):

Highlighted Publications

Walsh PD, Kurup D, Hasselschwert DL, Wirblich C, Goetzmann JE, Schnell MJ. The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? Sci Rep. 2017;7:43339. doi: 10.1038/srep43339. PubMed.

In this study, we showed that apes can be orally immunized against rabies virus and Ebola virus. Ebola virus is not only a killer of humans but also kills the endangered great apes and protection is urgently needed.

Johnson RF, Kurup D, Hagen KR, Fisher C, Keshwara R, Papaneri A, Perry DL, Cooper K, Jahrling PB, Wang JT, Ter Meulen J, Wirblich C, Schnell MJ. An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models. The Journal of infectious diseases. 2016;214(suppl 3):S342-S54. doi: 10.1093/infdis/jiw231. PubMed

This publication provides evidence that a deactivated rabies virus-based vaccine protects against Ebola virus in non-human primates. The deactivated vaccine is currently being further developed and will soon move in phase 1 clinical trials in humans.

Reardon TR, Murray AJ, Turi GF, Wirblich C, Croce KR, Schnell MJ, Jessell TM, Losonczy A. Rabies Virus CVS-N2c Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability. Neuron. 2016.

Rabies virus naturally infects neurons and can therefore be manipulated into is an excellent tracing tool to analyze neuroanatomy and neuronal connections.

Pfaller CK, Cattaneo R, Schnell MJ. Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics. Virology. 2015;479-480:331-44.

This publication provides a comprehensive overview of the use of mononegavirales virus-based viral vectors, a major interest of our laboratory.

Davis BD, Rall GF, Schnell MJ. Everything you always wanted to know about rabies virus (but were afraid to ask). In: Enquist D, DiMaio, editor. Annual Review of Virology. Palo Alto, California, USA: Annual Reviews; 2015. p. 51-71.

This article gives an overview of the rabies virus, the molecular virology of which is the foundational expertise of our lab.

Recent Publications

The Potential of Genetics in Identifying Women at Lower Risk of Breast Cancer

Evaluating self-vs interviewer-administered screening for depression in sickle cell disease

Gas-Phase Characterization of Adipic Acid, 6-Hydroxycaproic Acid, and Their Thermal Decomposition Products by Rotational Spectroscopy

Weak hydrogen bonding to halogens and chirality communication in propanols: Raman and microwave spectroscopy benchmark theory

Intensive Voice Treatment following Botulinum Neurotoxin Injection for a Speaker with Abductor Laryngeal Dystonia: An Exploratory Case Study

The Development of a Rabies Virus-Vectored Vaccine against Borrelia burgdorferi, Targeting BBI39

A Single Amino Acid Substitution in the Transmembrane Domain of Glycoprotein H Functionally Compensates for the Absence of gL in Pseudorabies Virus

Overcoming Repeated Testing Schedule Bias in Estimates of Disease Prevalence

Wetting of a Hydrophobic Surface: Far-IR Action Spectroscopy and Dynamics of Microhydrated Naphthalene

Survival outcomes seen with neoadjuvant chemotherapy in the management of locally advanced inflammatory breast cancer (IBC) versus matched controls

Increasing Complexity in Adamantyl Thioethers Characterized by Rotational Spectroscopy

GP38 as a vaccine target for Crimean-Congo hemorrhagic fever virus

Inducing transient enantiomeric excess in a molecular quantum racemic mixture with microwave fields

Effects of adjuvants in a rabies-vectored Ebola virus vaccine on protection from surrogate challenge

Conformations of borneol and isoborneol in the gas phase: Their monomers and microsolvation clusters

A feasibility randomized controlled trial of an mHealth app vs booklets for patient-facing guidelines in adults with SCD

Genetic counseling and testing for females at elevated risk for breast cancer: Protocol for the randomized controlled trial of the Know Your Risk intervention

Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis

Digital Health and its impact on the interaction between patients, caregivers and physicians

Hydrogen-Atom Tunneling in a Homochiral Environment

Detection of ethynylbenzene in TMC-1 and the interstellar search for 1,2-diethynylbenzene

The Immunomodulatory Effects of Dexamethasone on Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer

Microwave Three-Wave Mixing Spectroscopy of Chiral Molecules in Weakly Bound Complexes

Quantum Tunneling Facilitates Water Motion across the Surface of Phenanthrene

Controlling the false-discovery rate when identifying the subgroup benefiting from treatment