Walsh PD, Kurup D, Hasselschwert DL, Wirblich C, Goetzmann JE, Schnell MJ. The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? Sci Rep. 2017;7:43339. doi: 10.1038/srep43339. PubMed.
In this study, we showed that apes can be orally immunized against rabies virus and Ebola virus. Ebola virus is not only a killer of humans but also kills the endangered great apes and protection is urgently needed.
Johnson RF, Kurup D, Hagen KR, Fisher C, Keshwara R, Papaneri A, Perry DL, Cooper K, Jahrling PB, Wang JT, Ter Meulen J, Wirblich C, Schnell MJ. An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models. The Journal of infectious diseases. 2016;214(suppl 3):S342-S54. doi: 10.1093/infdis/jiw231. PubMed
This publication provides evidence that a deactivated rabies virus-based vaccine protects against Ebola virus in non-human primates. The deactivated vaccine is currently being further developed and will soon move in phase 1 clinical trials in humans.
Reardon TR, Murray AJ, Turi GF, Wirblich C, Croce KR, Schnell MJ, Jessell TM, Losonczy A. Rabies Virus CVS-N2c Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability. Neuron. 2016.
Rabies virus naturally infects neurons and can therefore be manipulated into is an excellent tracing tool to analyze neuroanatomy and neuronal connections.
Pfaller CK, Cattaneo R, Schnell MJ. Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics. Virology. 2015;479-480:331-44.
This publication provides a comprehensive overview of the use of mononegavirales virus-based viral vectors, a major interest of our laboratory.
Davis BD, Rall GF, Schnell MJ. Everything you always wanted to know about rabies virus (but were afraid to ask). In: Enquist D, DiMaio, editor. Annual Review of Virology. Palo Alto, California, USA: Annual Reviews; 2015. p. 51-71.
This article gives an overview of the rabies virus, the molecular virology of which is the foundational expertise of our lab.
Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R