Contact
- Chair, Department of Microbiology & Immunology
- Dr. V. Watson Pugh & Frances Plimpton Pugh Professor in Microbiology & Immunology
233 South Tenth Street
BLSB-531
Philadelphia, PA 19107
Highlighted Publications
Walsh PD, Kurup D, Hasselschwert DL, Wirblich C, Goetzmann JE, Schnell MJ. The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? Sci Rep. 2017;7:43339. doi: 10.1038/srep43339. PubMed.
In this study, we showed that apes can be orally immunized against rabies virus and Ebola virus. Ebola virus is not only a killer of humans but also kills the endangered great apes and protection is urgently needed.
Johnson RF, Kurup D, Hagen KR, Fisher C, Keshwara R, Papaneri A, Perry DL, Cooper K, Jahrling PB, Wang JT, Ter Meulen J, Wirblich C, Schnell MJ. An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models. The Journal of infectious diseases. 2016;214(suppl 3):S342-S54. doi: 10.1093/infdis/jiw231. PubMed
This publication provides evidence that a deactivated rabies virus-based vaccine protects against Ebola virus in non-human primates. The deactivated vaccine is currently being further developed and will soon move in phase 1 clinical trials in humans.
Reardon TR, Murray AJ, Turi GF, Wirblich C, Croce KR, Schnell MJ, Jessell TM, Losonczy A. Rabies Virus CVS-N2c Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability. Neuron. 2016.
Rabies virus naturally infects neurons and can therefore be manipulated into is an excellent tracing tool to analyze neuroanatomy and neuronal connections.
Pfaller CK, Cattaneo R, Schnell MJ. Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics. Virology. 2015;479-480:331-44.
This publication provides a comprehensive overview of the use of mononegavirales virus-based viral vectors, a major interest of our laboratory.
Davis BD, Rall GF, Schnell MJ. Everything you always wanted to know about rabies virus (but were afraid to ask). In: Enquist D, DiMaio, editor. Annual Review of Virology. Palo Alto, California, USA: Annual Reviews; 2015. p. 51-71.
This article gives an overview of the rabies virus, the molecular virology of which is the foundational expertise of our lab.
Publications
- Inactivated rabies-based Lassa fever virus vaccine candidate LASSARAB protects nonhuman primates from lethal disease
- Toward the Development of a Pan-Lyssavirus Vaccine
- The Development of a Rabies Virus-Vectored Vaccine against Borrelia burgdorferi, Targeting BBI39
- GP38 as a vaccine target for Crimean-Congo hemorrhagic fever virus
- Effects of adjuvants in a rabies-vectored Ebola virus vaccine on protection from surrogate challenge
- Inactivated rabies-vectored SARS-CoV-2 vaccine provides long-term immune response unaffected by vector immunity
- Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract
- Current vaccine strategies against SARS-CoV-2: Promises and challenges
- A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model
- A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
- A strategy to detect emerging non-delta sars-cov-2 variants with a monoclonal antibody specific for the n501 spike residue
- Tetravalent Rabies-Vectored Filovirus and Lassa Fever Vaccine Induces Long-term Immunity in Nonhuman Primates
- SARS-CoV-2 vaccines — the biggest medical research project of the 21st century
- Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model
- Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2
- Rhabdoviruses as vectors for vaccines and therapeutics
- Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups
- Rabies Little Virus Against Powerful Innate Immunity
- Identification and characterization of a small-molecule rabies virus entry inhibitor
- Publisher Correction: Rabies-based vaccine induces potent immune responses against Nipah virus (npj Vaccines, (2019), 4, 1, (15), 10.1038/s41541-019-0109-5)