Schnell Research
Matthias J. Schnell, MS, PhD

Contact

Name: Matthias J. Schnell, MS, PhD
Position: Professor & Chair, SKMC Microbiology & Immunology

233 South Tenth Street
BLSB-531
Philadelphia, PA 19107

Telephone: 215-503-4830

Highlighted Publications

Walsh PD, Kurup D, Hasselschwert DL, Wirblich C, Goetzmann JE, Schnell MJ. The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? Sci Rep. 2017;7:43339. doi: 10.1038/srep43339. PubMed.

In this study, we showed that apes can be orally immunized against rabies virus and Ebola virus. Ebola virus is not only a killer of humans but also kills the endangered great apes and protection is urgently needed.

Johnson RF, Kurup D, Hagen KR, Fisher C, Keshwara R, Papaneri A, Perry DL, Cooper K, Jahrling PB, Wang JT, Ter Meulen J, Wirblich C, Schnell MJ. An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models. The Journal of infectious diseases. 2016;214(suppl 3):S342-S54. doi: 10.1093/infdis/jiw231. PubMed

This publication provides evidence that a deactivated rabies virus-based vaccine protects against Ebola virus in non-human primates. The deactivated vaccine is currently being further developed and will soon move in phase 1 clinical trials in humans.

Reardon TR, Murray AJ, Turi GF, Wirblich C, Croce KR, Schnell MJ, Jessell TM, Losonczy A. Rabies Virus CVS-N2c Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability. Neuron. 2016.

Rabies virus naturally infects neurons and can therefore be manipulated into is an excellent tracing tool to analyze neuroanatomy and neuronal connections.

Pfaller CK, Cattaneo R, Schnell MJ. Reverse genetics of Mononegavirales: How they work, new vaccines, and new cancer therapeutics. Virology. 2015;479-480:331-44.

This publication provides a comprehensive overview of the use of mononegavirales virus-based viral vectors, a major interest of our laboratory.

Davis BD, Rall GF, Schnell MJ. Everything you always wanted to know about rabies virus (but were afraid to ask). In: Enquist D, DiMaio, editor. Annual Review of Virology. Palo Alto, California, USA: Annual Reviews; 2015. p. 51-71.

This article gives an overview of the rabies virus, the molecular virology of which is the foundational expertise of our lab.

Recent Publications

Dynamic chiral self-recognition in aromatic dimers of styrene oxide revealed by rotational spectroscopy

SARS-CoV-2 transmission in educational settings during an early summer epidemic wave in Luxembourg, 2020

How does the composition of a PAH influence its microsolvation? A rotational spectroscopy study of the phenanthrene-water and phenanthridine-water clusters

Prescribing of Opioid Analgesics and Buprenorphine for Opioid Use Disorder during the COVID-19 Pandemic

Trends in Drug Overdose Mortality in Ohio during the First 7 Months of the COVID-19 Pandemic

Do Docking Sites Persist Upon Fluorination? The Diadamantyl Ether-Aromatics Challenge for Rotational Spectroscopy and Theory

Deciphering the rotational spectrum of the first excited torsional state of propylene oxide

Rotational spectroscopy of imidazole: Accurate spectroscopic information for three vibrationally excited states and the heavy-atom isotopologues up to 295 GHz

Flight Trial Demonstration of Secure GBAS via the L-band Digital Aeronautical Communications System (LDACS)

Introducing SMRTT: A structural equation model of multimodal real-time trust

Unlocking the Water Trimer Loop: Isotopic Study of Benzophenone-(H2O)1–3 Clusters with Rotational Spectroscopy

Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model

Real-space observation of vibrational strong coupling between propagating phonon polaritons and organic molecules

Switching Hydrogen Bonding to π-Stacking: The Thiophenol Dimer and Trimer

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R

Palliative Care Referral Patterns for Adolescent and Young Adult Patients at a Comprehensive Cancer Center

Publisher Correction: Real-space observation of vibrational strong coupling between propagating phonon polaritons and organic molecules (Nature Photonics, (2020), 10.1038/s41566-020-00725-3)

High-resolution infrared spectroscopy of naphthalene and acenaphthene dimers

Reg1 and Snf1 regulate stress-induced relocalization of protein phosphatase-1 to cytoplasmic granules

Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis

Structures and internal dynamics of diphenylether and its aggregates with water

New findings from old data: A semi-experimental value for the eQq of the nitrogen atom

Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2

Hyperpolarized NMR Metabolomics at Natural 13C Abundance

Assessing the performance of rotational spectroscopy in chiral analysis