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Pera Research

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Tonio Pera, PhD
Assistant Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Department of Medicine

1020 Locust Street
JAH, Room 236
Philadelphia, PA 19107

Highlighted Publications

Pera T, Penn RB. Methods to Investigate β-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle.  Methods Mol Biol. 2019;1957:69-82. doi: 10.1007/978-1-4939-9158-7_4. PMID: 30919347

This paper details methods for studying the role of arrestins in regulating GPCR functions in airway smooth muscle cells.

Pera T, Tompkins E, Katz M, Wang B, Deshpande DA, Weinman EJ, Penn RB. Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle. FASEB J. 2019 Aug;33(8):9008-9016. doi: 10.1096/fj.201900323R. Epub 2019 May 1. PMID: 31042404

This paper reveals NHERF1 acts as an adapter to compartmentalize cAMP signaling in airway smooth muscle.

Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr, Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 Feb;32(2):862-874. PMID: 29042451

This is the first paper to identify small molecule ligands for the proton-sensing receptor OGR1 and determine the capacity of ligands to selectively bias signaling towards Gs pathways but not Gq pathways.

Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. FASEB J. 2015 Oct;29(10):4227-35. PMID: 26103985

This paper details how arrestins differentially regulate muscarinic and adrenergic receptor signaling in airway smooth muscle to affect contraction and relaxation.

Recent Publications

The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype

PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells

Pharmacological Management of Asthma and COPD

Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle

Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling

Laminin α4 contributes to airway remodeling and inflammation in asthma

Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle

Methods to Investigate β-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle

Pepducins as a potential treatment strategy for asthma and COPD

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines

G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung Disease

An official American thoracic society research statement: Current challenges facing research and therapeutic advances in airway remodeling

Phosphodiesterase 4 inhibitors attenuate the asthma phenotype produced by β2-adrenoceptor agonists in phenylethanolamine N-methyltransferase-knockout mice

Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells

Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function

Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response

Airway smooth muscle in asthma: Linking contraction and mechanotransduction to disease pathogenesis and remodelling

Arginase inhibition prevents Inflammation and Remodeling in a Guinea Pig model of Chronic obstructive Pulmonary disease

Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway

Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle

Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype

Role for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells

TAK1 plays a major role in growth factor-induced phenotypic modulation of airway smooth muscle

Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD

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