Milligan Research
CONTACT
4201 Henry Avenue
Hayward Hall, Room 220B
Philadelphia, PA 19144
Publications
Cooper, S.E.; Kabashi, D.; Yacoub, M.; Molen, J.; Farhan, O.; Farley, C.; Yencha, S.; FIgueiredo, M.; Phadnis, N.; Henry, W.; Wilkinson, F.; Milligan, J.A. Fluorine-Containing Isosteres Enable a Structure-Activity Relationship Study of Gingerol Derivatives. J. Fluorine Chem. 2025, 282, 110400. Link
Milligan, J.A.; Molen, J.A.; Phadnis, N.; Tomaselli, D. Washington, M.P. Partial and Complete Reduction of Pyrroles, Furans, Thiophenes, and their Benzo Analogs; Heterocycles containing more than one Heteroatom. In Comprehensive Organic Synthesis, 3rd edition. Link
Brodsky, N.; Phadnis, N.; Ibrahim, M.; Andino, I. M.; Blanc Giro, I.; Milligan, J.A. 3-Chloropropylbis(catecholato)silicate as a Bifunctional Reagent for the One-pot Synthesis of Tetrahydroquinolines from o-Bromosulfonamides. J. Org. Chem. 2024, 89, 4191-4198. Link
Phadnis, N.; Molen, J.; Stephens, S.; Lambert, K.M.; Milligan, J.A. Green Oxidation of Aromatic Hydrazide Derivatives Using an Oxoammonium Salt. J. Org. Chem. 2024, 89, 5841-5845. Link
Milligan, J.A.; Vowell, C.; Crocker, D.L.; Wipf, P. Hydrozirconation of Alkynes. Organic Reactions, 2023, 113, 457. Link
Kelly, C.B., Milligan, J.A., Jouffroy, M. Discussion addendum for: Preparation of diisopropylammonium bis(catecholato)cyclohexylsilicate. Org. Synth., 2022, 99, 342-362. Link
Kelly, C.B.*, Milligan, J.A.*, Tilley, L.J; Sodano, T.M. Biocyclobutanes: From Curiosities toVersatile Reagents and Covalent Warheads. Chem. Sci., 2022, 13, 11721-11737. Link
Lambert, K.B.; Kelly, C.B.; Milligan, J.A.; Tilley, L.J.; Reynolds, R.P.; McGuire, K.P.; Anzalone, L.; Del Sesto, K.E.; Walsh, S. A Practical Oxidation Experiment for Undergraduate Students: Bobbitt’s Salt as a “Green” Alternative. J. Chem. Educ., 2022, 99, 3249-2358. Link
Milligan, J.A. What Is the Value of Synchronous Engagement in Small Remote Organic Chemistry Classes? Analysis of Multiple-Choice Polling Data from the COIVD-Impacted Spring Semester of 2020. J. Chem. Educ. 2020, 97, 3206-3210. Link
Graduate Work/Research
Milligan, J.A.; Burns, K.L.; Le, A.V.; Wang, Z.; Polites, V.C.; Molander, G.A.; Kelly, C.B. Radical-Polar Crossover Annulation: A Platform for Accessing Polycyclic Cyclopropanes. Adv. Synth. Catal. 2020, 362, 242-247. Link
Pantaine, L.R.; Milligan, J.A.; Matsui, J.K.; Kelly, C.B.; Molander, G.A. Photoredox Radical/Polar Crossover Enables Construction of Saturated Nitrogen Heterocycles. Org. Lett. 2019, 21, 2317-2321. Link
Milligan, J.A.*; Phelan, J.P*.; Badir, S.O.; Molander, G.A. Alkyl Carbon-Carbon Bond Formation by Nickel/Photoredox Cross-Coupling. Angew. Chem. Int. Ed. 2019, 58, 6152-6163. Link
Milligan, J.A.; Phelan, J.P.; Polites, V.C.; Kelly, C.B.; Molander, G.A. Radical/Polar Annulation Reactions Enable the Modular Construction of Cyclopropanes. Org. Lett. 2018, 20, 6840-6844. Link
Huston, E. M.; Milligan, J.A.; Powell, J.R. Smith, A.M.; Neal, D.; Duval, K.M.; DiNardo, M.A.; Stoddard, C.; Bell, P.A.; Berning, A.W.; Wipf, P.; Bandik, G.C. Development of an Undergraduate Course in Chemical Laboratory Safety through an Academic/Industrial Collaboration. J. Chem. Educ. 2018, 95, 577-583. Link
Milligan, J.A.; Busacca, C.A.; Senanayake, C.H.; Wipf, P. Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles. Org. Lett. 2016, 18, 4300-4303. Link
Milligan, J.A.; Wipf, P. Straining to React. Nat. Chem. 2016, 8, 296-297 (News & Views Feature) Link
Busacca, C.A.; Milligan, J.A.; Rattanangkool, E.; Ramavarapu, C.; Chen, A.; Saha, A.K.; Li, Z.; Lee, H.; Geib, S J.; Wang, G.; Senanayake, C.H.; Wipf, P. Synthesis of Phosphaguanidines by Hydrophosphination of Carbodiimides with Phosphine Boranes. J. Org. Chem. 2014, 79, 9878-9887. Link
Peer-Reviewed Publications
- Green Oxidation of Aromatic Hydrazide Derivatives Using an Oxoammonium Salt
- 3-Chloropropylbis(catecholato)silicate as a Bifunctional Reagent for the One-Pot Synthesis of Tetrahydroquinolines from o-Bromosulfonamides
- Hydrozirconation of alkynes
- Bicyclobutanes: from curiosities to versatile reagents and covalent warheads
- A Practical Oxidation Experiment for Undergraduate Students: Bobbitt's Salt as a "green" Alternative
- What Is the Value of Synchronous Engagement in Small Remote Organic Chemistry Classes? Analysis of Multiple-Choice Polling Data from the COVID-Impacted Spring Semester of 2020
- Radical-Polar Crossover Annulation: A Platform for Accessing Polycyclic Cyclopropanes
- Alkyl-C-C-Bindungsbildung durch Nickel/Photoredox-Kreuzkupplung
- Alkyl Carbon–Carbon Bond Formation by Nickel/Photoredox Cross-Coupling
- Photoredox Radical/Polar Crossover Enables Construction of Saturated Nitrogen Heterocycles
- Radical/Polar Annulation Reactions (RPARs) Enable the Modular Construction of Cyclopropanes
- Development of an undergraduate course in chemical laboratory safety through an academic/industrial collaboration
- Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles
- Click chemistry: Straining to react
- Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes