Merry Research
Contact
Name:
Diane Merry, PhD
Position:
- Professor
- Vice Chair, Faculty Development & Engagement
Position:
Department of Biochemistry & Molecular Biology
Organization:
Sidney Kimmel Medical College
1020 Locust Street
416 Jefferson Alumni Hall
Philadelphia, PA 19107
Email:
Diane.Merry@jefferson.edu
Contact Number(s):
Highlighted Publications
- Karliner and Merry, 2023. Differentiating PC12 cells to evaluate neurite densities through live-cell imaging
- Molotsky et al., 2022. Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy
- Pluciennik et al., 2021. Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy
Recent Reviews
- Sengupta et al., 2022. The role of ubiquitination in spinal and bulbar muscular atrophy
- Arnold and Merry, 2019. Molecular Mechanisms and Therapeutics for SBMA/Kennedy's Disease
Other Publications
- Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA
- Blocking the dimerization of polyglutamine-expanded androgen receptor protects cells from DHT-induced toxicity by increasing AR turnover
- Differentially disrupted spinal cord and muscle energy metabolism in spinal and bulbar muscular atrophy
- A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila
- Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice
- Differentiating PC12 cells to evaluate neurite densities through live-cell imaging
- Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy
- The role of ubiquitination in spinal and bulbar muscular atrophy
- Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy
- Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy
- Molecular Mechanisms and Therapeutics for SBMA/Kennedy’s Disease
- Fluorescence Imaging of Huntingtin mRNA Knockdown
- The 11s proteasomal activator regγ impacts polyglutamine-expanded androgen receptor aggregation and motor neuron viability through distinct mechanisms
- The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/CCdh1 ubiquitin ligase complex
- Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy
- Proteasome-mediated Proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis
- Inhibition of Stat5a/b enhances proteasomal degradation of androgen receptor liganded by antiandrogens in prostate cancer
- Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease
- Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features
- Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA