My lab has been involved in pharmacokinetic analyses of drug disposition in humans and animal models.  We have developed and published in the area of LCMS therapeutic drug monitoring with our analytical expertise for various therapeutic agents.  Our lab is actively collaborating with the Division of Clinical Pharmacology at TJU.  For one of the study, a simultaneous pharmacokinetic analysis of midazolam and ketamine method was developed using LCMS.  This project resulted in two poster abstracts, one oral presentation, and two publications in international journals.  We are currently working with Division of Clinical Pharmacology on pharmacokinetic analysis of azithromycin and aspirin.  This projected has led to successful funding from NIH (R21) and EW Thrasher Foundation. 

1. Eudy-Byrne R, Zane N, Adeniyi-Jones SC, Gastonguay MR, Ruiz-Garcia A, Kaushal G, Kraft WK. Pharmacometric dose optimization of Buprenorphine in Neonatal Opioid Withdrawal Syndrome. Clin Transl Sci. 2021 Jun 3. Epub ahead of print. PMID: 34080312
2. Boelig R, Rochani A, Lam E, Kaushal G, Roman A, Kraft W (2021). Noninvasive Amniotic Fluid Sampling to Evaluate the Pharmacokinetics and Pharmacodynamics of Maternal Azithromycin in the Fetal Compartment. Accepted for publication in Clinical and Translational Science on May 17th 2021.
3. Rochani A, Lam E, Tanjuakio J, Hirose H, Kraft WK, Kaushal G. Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy. J Pharm Biomed Anal. 2020 Jan 30;178:112947. PMID: 31708269 PMCID: PMC7041885
4. Lam E, Rochani A, Kaushal G, Thoma BN, Tanjuakio J, West FM, Hirose H. Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy. Clin Ther. 2019 May;41(5):994-999. PMID: 30929859 PMCID: PMC7197266