Kaushal Research
Contact
Name:
Gagan Kaushal, PhD
Position:
- Associate Professor
Position:
Pharmaceutical Science
1020 Locust Street
Room 230A
Philadelphia, PA 19107
Email:
Gagan.Kaushal@jefferson.edu
Contact Number(s):
Highlighted Publications
My lab has been involved in pharmacokinetic analyses of drug disposition in humans and animal models. We have developed and published in the area of LCMS therapeutic drug monitoring with our analytical expertise for various therapeutic agents. Our lab is actively collaborating with the Division of Clinical Pharmacology at TJU. For one of the study, a simultaneous pharmacokinetic analysis of midazolam and ketamine method was developed using LCMS. This project resulted in two poster abstracts, one oral presentation, and two publications in international journals. We are currently working with Division of Clinical Pharmacology on pharmacokinetic analysis of azithromycin and aspirin. This projected has led to successful funding from NIH (R21) and EW Thrasher Foundation.
- Eudy-Byrne R, Zane N, Adeniyi-Jones SC, Gastonguay MR, Ruiz-Garcia A, Kaushal G, Kraft WK. Pharmacometric dose optimization of Buprenorphine in Neonatal Opioid Withdrawal Syndrome. Clin Transl Sci. 2021 Jun 3. Epub ahead of print. PMID: 34080312
- Boelig R, Rochani A, Lam E, Kaushal G, Roman A, Kraft W (2021). Noninvasive Amniotic Fluid Sampling to Evaluate the Pharmacokinetics and Pharmacodynamics of Maternal Azithromycin in the Fetal Compartment. Accepted for publication in Clinical and Translational Science on May 17th 2021.
- Rochani A, Lam E, Tanjuakio J, Hirose H, Kraft WK, Kaushal G. Simultaneous quantitative LC-MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy. J Pharm Biomed Anal. 2020 Jan 30;178:112947. PMID: 31708269 PMCID: PMC7041885
- Lam E, Rochani A, Kaushal G, Thoma BN, Tanjuakio J, West FM, Hirose H. Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy. Clin Ther. 2019 May;41(5):994-999. PMID: 30929859 PMCID: PMC7197266
Recent Publications
- Long-Term Stability, Sterility, And Cost-Effectiveness of 0.05% Chlorhexidine Gluconate as Antisepsis for Intravitreal Injection
- Azithromycin dosing and preterm premature rupture of membranes treatment (ADAPT): a randomized controlled Phase I trial
- Aspirin pharmacokinetics and pharmacodynamics through gestation
- Population pharmacokinetic and safety analysis of ropivacaine used for erector spinae plane blocks
- Improved Tumor Control Following Radiosensitization with Ultrasound-Sensitive Oxygen Microbubbles and Tumor Mitochondrial Respiration Inhibitors in a Preclinical Model of Head and Neck Cancer
- Tumoral oxygenation and biodistribution of Lonidamine oxygen microbubbles following localized ultrasound-triggered delivery
- Development and Preclinical Investigation of Physically Cross-Linked and pH-Sensitive Polymeric Gels as Potential Vaginal Contraceptives
- Development of a Dual Drug-Loaded, Surfactant-Stabilized Contrast Agent Containing Oxygen
- Randomized trial of prophylactic antibiotics vs. placebo after midshaft-to-distal hypospadias repair: the PROPHY Study
- Stability-indicating HPLC method to determine the stability of extemporaneously prepared vancomycin oral solution cups
- Longitudinal evaluation of azithromycin and cytokine concentrations in amniotic fluid following one-time oral dosing in pregnancy
- Stability-indicating lc-ms method for determination of stability of extemporaneously compounded buprenorphine oral syringes for neonatal abstinence syndrome
- Symptoms of gluten ingestion in patients with non-celiac gluten sensitivity: A randomized clinical trial
- Incubation Method for Loading Lonidamine in Oxygen Microbubbles for Targeted Drug Delivery
- Sphenopalatine ganglion stimulation upregulates transport of temozolomide across the blood-brain barrier
- LC-MS based stability-indicating method for studying the degradation of lonidamine under physical and chemical stress conditions
- Heat shock protein 90 (Hsp90)-inhibitor-luminespib-loaded-protein-based nanoformulation for cancer therapy
- Compatibility of treprostinil sodium and dopamine hydrochloride during simulated Y-site administration
- Expression of tryptophan 2,3-dioxygenase in metastatic uveal melanoma
- Simultaneous quantitative LC–MS method of ketamine, midazolam and their metabolites (dehydronorketamine, norketamine and 1hydroxymidazolam) for its application in patients on extracorporeal membrane oxygenation (ECMO) therapy
- Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy
- D-cycloserine nasal formulation development for anxiety disorders by using polymeric gels
- Dental care-related fear and anxiety: Distress tolerance as a possible mechanism
- A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain
- Stability of extemporaneously compounded diltiazem hydrochloride infusions stored in polyolefin bags.