Eishen Research

Contact

Name: Christine Eischen, PhD
Position: Professor

233 South 10th Street
BLSB 650
Philadelphia, PA 19107

Contact Number(s):

Highlighted Publications

Edmonds, M.D., Boyd, K. L. , Moyo, T., Mitra, R., Duszynski, R., Arrate, M.P., Chen, X., Zhao, Z., Blackwell, T.S., Andl, T., and Eischen, C.M.  miR-31 initiates lung tumorigenesis and promotes mutant KRas-driven lung cancer, J. Clinical Invest., 126(1):349-64, 2016.

Adams, C.M., Hiebert, S.W. and Eischen, C.M. Myc induces miRNA-mediated apoptosis in response to HDAC inhibition in hematological malignancies. Cancer Research 76(3):736-48, 2016.

McGirt, L.Y., Jia, P., Baerenwald, D.A., Duszynski, R.J., Dahlman, K.B.,  Zic, J.A.,  Zwerner, J.P., Hucks, D., Dave, Z.,  Zhao, Z., and Eischen, C.M.  Whole genome sequencing reveals oncogenic mutations in mycosis fungoides. Blood 126(4):508-19, 2015.

Carrillo, A.M., Bouska, A., Arrate, M.P. and Eischen, C.M.. Mdmx promotes genomic instability independent of p53 and Mdm2. Oncogene 34(7):846-56, 2015.

Grieb, B.C., Gramling, M.W., Arrate, M.P., Chen, X., Beauparlant, S.L.,  Haines, D.S., Xiao, H., and  Eischen, C.M. Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. Cancer Research 74(13):3591-602, 2014.

Recent Publications

C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer

Engaging community members in cancer research: an assessment of an NCI-designated cancer center

CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research

Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming

MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging

Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression

Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs

Mircorrnet: Machine learning-based integration of mirna and mrna expression profiles, combined with feature grouping and ranking

Myc regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival

MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors

Mdm4 supports DNA replication in a p53-independent fashion

Targeting MYC through WDR5

Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

IL-33 is a cell-intrinsic regulator of fitness during early B cell development

MicroRNA-21 is Required for Hematopoietic Cell Viability After Radiation Exposure

SMARCAL1 and ZrAnB3 protect replication forks from MYC-induced DNA replication stress

The role of inhibition of apoptosis in acute leukemias and myelodysplastic syndrome

Targeting the Bcl-2 family in B cell lymphoma

Targeting of SGK1 by miR-576-3p inhibits lung adenocarcinoma migration and invasion

The proto-oncogene function of Mdm2 in bone

Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition

Non-Hodgkin and Hodgkin lymphomas select for overexpression of BCLW