Christine Eischen, PhD


Name: Christine Eischen, PhD
Position: Professor

233 South 10th Street
BLSB 650
Philadelphia, PA 19107

Telephone: 215-503-8890

Highlighted Publications

Edmonds, M.D., Boyd, K. L. , Moyo, T., Mitra, R., Duszynski, R., Arrate, M.P., Chen, X., Zhao, Z., Blackwell, T.S., Andl, T., and Eischen, C.M.  miR-31 initiates lung tumorigenesis and promotes mutant KRas-driven lung cancer, J. Clinical Invest., 126(1):349-64, 2016.

Adams, C.M., Hiebert, S.W. and Eischen, C.M. Myc induces miRNA-mediated apoptosis in response to HDAC inhibition in hematological malignancies. Cancer Research 76(3):736-48, 2016.

McGirt, L.Y., Jia, P., Baerenwald, D.A., Duszynski, R.J., Dahlman, K.B.,  Zic, J.A.,  Zwerner, J.P., Hucks, D., Dave, Z.,  Zhao, Z., and Eischen, C.M.  Whole genome sequencing reveals oncogenic mutations in mycosis fungoides. Blood 126(4):508-19, 2015.

Carrillo, A.M., Bouska, A., Arrate, M.P. and Eischen, C.M.. Mdmx promotes genomic instability independent of p53 and Mdm2. Oncogene 34(7):846-56, 2015.

Grieb, B.C., Gramling, M.W., Arrate, M.P., Chen, X., Beauparlant, S.L.,  Haines, D.S., Xiao, H., and  Eischen, C.M. Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. Cancer Research 74(13):3591-602, 2014.

Recent Publications

Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival

MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors

Mdm4 supports DNA replication in a p53-independent fashion

Targeting MYC through WDR5

Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

IL-33 is a cell-intrinsic regulator of fitness during early B cell development

MicroRNA-21 is Required for Hematopoietic Cell Viability After Radiation Exposure

SMARCAL1 and ZrAnB3 protect replication forks from MYC-induced DNA replication stress

Targeting the Bcl-2 family in B cell lymphoma

Targeting of SGK1 by miR-576-3p inhibits lung adenocarcinoma migration and invasion

The role of inhibition of apoptosis in acute leukemias and myelodysplastic syndrome

The proto-oncogene function of Mdm2 in bone

Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition

Non-Hodgkin and Hodgkin lymphomas select for overexpression of BCLW

Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition

Mdm2 is required for survival and growth of p53-deficient cancer cells

Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution

Role of Mdm2 and Mdmx in DNA repair

BCL-W has a fundamental role in B cell survival and lymphomagenesis