Contact
233 South 10th Street
BLSB 650
Philadelphia, PA 19107
Highlighted Publications
Edmonds, M.D., Boyd, K. L. , Moyo, T., Mitra, R., Duszynski, R., Arrate, M.P., Chen, X., Zhao, Z., Blackwell, T.S., Andl, T., and Eischen, C.M. miR-31 initiates lung tumorigenesis and promotes mutant KRas-driven lung cancer, J. Clinical Invest., 126(1):349-64, 2016.
Adams, C.M., Hiebert, S.W. and Eischen, C.M. Myc induces miRNA-mediated apoptosis in response to HDAC inhibition in hematological malignancies. Cancer Research 76(3):736-48, 2016.
McGirt, L.Y., Jia, P., Baerenwald, D.A., Duszynski, R.J., Dahlman, K.B., Zic, J.A., Zwerner, J.P., Hucks, D., Dave, Z., Zhao, Z., and Eischen, C.M. Whole genome sequencing reveals oncogenic mutations in mycosis fungoides. Blood 126(4):508-19, 2015.
Carrillo, A.M., Bouska, A., Arrate, M.P. and Eischen, C.M.. Mdmx promotes genomic instability independent of p53 and Mdm2. Oncogene 34(7):846-56, 2015.
Grieb, B.C., Gramling, M.W., Arrate, M.P., Chen, X., Beauparlant, S.L., Haines, D.S., Xiao, H., and Eischen, C.M. Oncogenic protein MTBP interacts with MYC to promote tumorigenesis. Cancer Research 74(13):3591-602, 2014.
Publications
- Identifying Targetable Vulnerabilities to Circumvent or Overcome Venetoclax Resistance in Diffuse Large B-Cell Lymphoma
- 4'-Ethynyl-2'-Deoxycytidine(EdC)PreferentiallyTargets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
- DNA fork remodeling proteins, Zranb3 and Smarcal1, are uniquely essential for aging hematopoiesis
- C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
- Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer
- Decoding the lncRNAome Across Diverse Cellular Stresses Reveals Core p53-effector Pan-cancer Suppressive lncRNAs
- Engaging community members in cancer research: an assessment of an NCI-designated cancer center
- CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research
- Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming
- MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging
- Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression
- Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs
- Mircorrnet: Machine learning-based integration of mirna and mrna expression profiles, combined with feature grouping and ranking
- Myc regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
- Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival
- MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors
- Mdm4 supports DNA replication in a p53-independent fashion
- Targeting MYC through WDR5
- Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma
- Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance