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Highlighted Publications
Geherin, S.A., et al., The skin, a novel niche for recirculating B cells. J Immunol, 2012. 188(12): p. 6027-35
Using our model of afferent lymph cannulation in sheep, this paper established the existence of skin-recirculating B cells and performed an initial characterization of skin B cell subsets and function.
Geherin, S.A., et al., IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require alpha4beta1 Integrin To Migrate between the Peritoneum and Inflamed Skin. J Immunol, 2016. 196(6): p. 2514-25.
This paper confirmed that B cells, including IL-10+ regulatory B cells, are part of the skin immune system of humans and mice.
Gomez, D., et al., Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation. J Immunol, 2015. 195(8): p. 3531-6.
In this paper we present a proof-of principle that the regulation of pro-inflammatory T cell egress from the effector site via afferent lymph governs the inflammatory process. We also demonstrated that tissue exit receptors can be targeted to modulate T cell dwell time and inflammation at effector sites, revealing T cell tissue egress via lymph as a control point of inflammation and novel potential target of anti-inflammatory therapy
Recent Publications
- Secreted IgM modulates IL-10 expression in B cells
- The Lack of Natural IgM Increases Susceptibility and Impairs Anti-Vi Polysaccharide IgG Responses in a Mouse Model of Typhoid
- Immunoregulation by antibody secreting cells in inflammation, infection, and cancer
- Skin-Homing Regulatory B Cells Required for Suppression of Cutaneous Inflammation
- Approaches to overcome flow cytometry limitations in the analysis of cells from veterinary relevant species
- IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation
- Lymphoplasmacellular mucositis ameliorated by α4β7 integrin inhibitor vedolizumab in a patient with ulcerative colitis
- B Cells and Melanoma Pathogenesis
- Skin-associated b cells in health and inflammation
- T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions
- IL-10+ innate-like B cells are part of the skin immune system and require α4β1 integrin to migrate between the peritoneum and inflamed skin
- Effector T cell egress via afferent lymph modulates local tissue inflammation
- CRK proteins selectively regulate T cell migration into inflamed tissues
- CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph
- Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza
- Ovine skin-recirculating γδ T cells express IFN-γ and IL-17 and exit tissue independently of CCR7
- Tissue exit: A novel control point in the accumulation of antigen-specific CD8 T cells in the influenza A virus-infected lung
- The skin, a novel niche for recirculating B cells
- Tissue exit: A novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung
- CCL8 and skin T cells-an allergic attraction