Covarrubias Research

Contact

Name: Manuel L. Covarrubias, MD, PhD
Position: Professor

233 South 10th Street
BLSB 231
Philadelphia, PA 19107

Contact Number(s):

Tyler D. Alexander
Medical Student/PhD Candidate

My Neuroscience PhD work elucidated the mechanism through which the potassium channel Kv3.4 and its phosphorylation by protein kinase C regulate the repolarization of the action potential in dorsal root ganglion neurons. This work shed light on the significance of spike broadening in pain signaling.

Kyle Kennedy
PhD Candidate

My Neuroscience PhD work is investigating the ionic membrane properties of enteric neuropod cells and their modulation by guanylyl cyclase 2C, which would help elucidate the mechanisms of visceral pain and identify novel potential therapeutic opportunities to treat irritable bowel syndrome.

Linh Nguyen-Phuong
Medical Student/PhD Candidate

My Neuroscience PhD work is investigating the electrophysiological basis of the modulation of glutamatergic signaling by EphB2 in the dorsal horn of the spinal cord. This work is elucidating how EphB2 dysregulation is implicated in the mechanism of spinal cord injury-induced neuropathic pain.

Qiansheng Liang, MD, PhD 
Research Assistant and Laboratory Manager

My recent research has focused on 1) the structural basis of the modulation of Kv3 channels by novel positive allosteric modulators; and 2) the receptor mediated signaling mechanism that modulates inactivation gating of Kv3.4 channels, which is potentially implicated in peripheral mechanisms of pain. 

Former Team Members

Former Members Role in Lab Current Position
Jennifer Miller Research Technician  
Tapan Vyas, PhD Postdoctoral Fellow  
Henry H Jerng, PhD Graduate Student (PhD) Assistant Professor, Baylor College of Medicine
Edward J Beck, PhD Graduate Student (PhD)  
Laura Escobar, PhD Postdoctoral Fellow Principal Investigator, UNAM, Mexico City
Maria T Pacheco-Cano, PhD Postdoctoral Fellow  
Mohammad Shahidullah, PhD Postdoctoral Fellow  
Ivan Velasco, PhD Visiting Scholar Principal Investigator, UNAM, Mexico City
Guangyu (Gary) Wang, PhD Postdoctoral Fellow  
Ricardo H Pineda, PhD Postdoctoral Fellow Research Assistant Professor, University of Pittsburgh
Thanawath Ratanadilok Na Phuket, PhD Graduate Student (PhD)  
Andrew Graber Research Technician Physician
Carmen A Rocha, MS, PA Graduate Student (MS) Physician Assistant
Benjamin Kaplan, MD Graduate Student (MS) Physician
Aditya Bhattacharji Research Assistant Veeva, Senior Director
Nathan J Klett Undergraduate Student Researcher, Leiden University, Netherlands
Kelly A Dougherty, PhD Graduate Student (PhD) Associate Professor, Rhodes College, Memphis, TN
Yuri A Kaulin, PhD Research Assistant Professor  
Jose A De Santiago-Castillo, PhD Postdoctoral Fellow  
Annika F Barber Graduate Student (PhD) Assistant Professor, Rutgers University-Waksman Institute
David M Ritter Graduate Student (MD/PhD) Assistant Professor, Child Neurology, Cincinnati Children's Hospital
Jeffrey D Fineberg Graduate Student (PhD) Principal, Bluestar / BioAdvisors
Benjamin Zemel Graduate Student (PhD) Assistant Professor, Ithaca College, NY
Shelly T Jones Graduate Student (MS) Budget and Policy Analyst, Colorado Department of Human Services
Brian Urbani Graduate Student (MS) Clinical Research Associate, PRA Health Sciences
Tanziyah Muqeem Graduate Student (MD/PhD) Assistant Professor, Neurology, University of North Carolina Chapel Hill
Elaine Yang Graduate Student (MD/PhD) Urology Resident, Cleveland Clinic
Lianteng Zhi, PhD Postdoctoral Fellow Biostatistician, Christiana Care
Andrew Sam Medical Student MD Candidate, SKMC