Covarrubias Research

Contact

Name: Manuel L. Covarrubias, MD, PhD
Position: Professor

233 South 10th Street
BLSB 231
Philadelphia, PA 19107

Contact Number(s):

Tyler D. Alexander
Medical Student/PhD Candidate

My Neuroscience PhD work elucidated the mechanism through which the potassium channel Kv3.4 and its phosphorylation by protein kinase C regulate the repolarization of the action potential in dorsal root ganglion neurons. This work shed light on the significance of spike broadening in pain signaling.

Kyle Kennedy
PhD Candidate

My Neuroscience PhD work is investigating the ionic membrane properties of enteric neuropod cells and their modulation by guanylyl cyclase 2C, which would help elucidate the mechanisms of visceral pain and identify novel potential therapeutic opportunities to treat irritable bowel syndrome.

Linh Nguyen-Phuong
Medical Student/PhD Candidate

My Neuroscience PhD work is investigating the electrophysiological basis of the modulation of glutamatergic signaling by EphB2 in the dorsal horn of the spinal cord. This work is elucidating how EphB2 dysregulation is implicated in the mechanism of spinal cord injury-induced neuropathic pain.

Qiansheng Liang, MD, PhD 
Research Assistant and Laboratory Manager

My recent research has focused on 1) the structural basis of the modulation of Kv3 channels by novel positive allosteric modulators; and 2) the receptor mediated signaling mechanism that modulates inactivation gating of Kv3.4 channels, which is potentially implicated in peripheral mechanisms of pain. 

Former Team Members

Former MembersRole in LabCurrent Position
Jennifer MillerResearch Technician 
Tapan Vyas, PhDPostdoctoral Fellow 
Henry H Jerng, PhDGraduate Student (PhD)Assistant Professor, Baylor College of Medicine
Edward J Beck, PhDGraduate Student (PhD) 
Laura Escobar, PhDPostdoctoral FellowPrincipal Investigator, UNAM, Mexico City
Maria T Pacheco-Cano, PhDPostdoctoral Fellow 
Mohammad Shahidullah, PhDPostdoctoral Fellow 
Ivan Velasco, PhDVisiting ScholarPrincipal Investigator, UNAM, Mexico City
Guangyu (Gary) Wang, PhDPostdoctoral Fellow 
Ricardo H Pineda, PhDPostdoctoral FellowResearch Assistant Professor, University of Pittsburgh
Thanawath Ratanadilok Na Phuket, PhDGraduate Student (PhD) 
Andrew GraberResearch TechnicianPhysician
Carmen A Rocha, MS, PAGraduate Student (MS)Physician Assistant
Benjamin Kaplan, MDGraduate Student (MS)Physician
Aditya BhattacharjiResearch AssistantVeeva, Senior Director
Nathan J KlettUndergraduate StudentResearcher, Leiden University, Netherlands
Kelly A Dougherty, PhDGraduate Student (PhD)Associate Professor, Rhodes College, Memphis, TN
Yuri A Kaulin, PhDResearch Assistant Professor 
Jose A De Santiago-Castillo, PhDPostdoctoral Fellow 
Annika F BarberGraduate Student (PhD)Assistant Professor, Rutgers University-Waksman Institute
David M RitterGraduate Student (MD/PhD)Assistant Professor, Child Neurology, Cincinnati Children's Hospital
Jeffrey D FinebergGraduate Student (PhD)Principal, Bluestar / BioAdvisors
Benjamin ZemelGraduate Student (PhD)Assistant Professor, Ithaca College, NY
Shelly T JonesGraduate Student (MS)Budget and Policy Analyst, Colorado Department of Human Services
Brian UrbaniGraduate Student (MS)Clinical Research Associate, PRA Health Sciences
Tanziyah MuqeemGraduate Student (MD/PhD)Assistant Professor, Neurology, University of North Carolina Chapel Hill
Elaine YangGraduate Student (MD/PhD)Urology Resident, Cleveland Clinic
Lianteng Zhi, PhDPostdoctoral FellowBiostatistician, Christiana Care
Andrew SamMedical StudentMD Candidate, SKMC