Covarrubias Research

Contact

Name: Manuel L. Covarrubias, MD, PhD
Position: Professor

233 South 10th Street
BLSB 231
Philadelphia, PA 19107

Contact Number(s):

Tyler D. Alexander
Medical Student/PhD Candidate

My Neuroscience PhD work elucidated the mechanism through which the potassium channel Kv3.4 and its phosphorylation by protein kinase C regulate the repolarization of the action potential in dorsal root ganglion neurons. This work shed light on the significance of spike broadening in pain signaling.

Kyle Kennedy
PhD Candidate

My Neuroscience PhD work is investigating the ionic membrane properties of enteric neuropod cells and their modulation by guanylyl cyclase 2C, which would help elucidate the mechanisms of visceral pain and identify novel potential therapeutic opportunities to treat irritable bowel syndrome.

Linh Phuog Nguyen
Medical Student/PhD Candidate

My Neuroscience PhD work is investigating the electrophysiological basis of the modulation of glutamatergic signaling by EphB2 in the dorsal horn of the spinal cord. This work is elucidating how EphB2 dysregulation is implicated in the mechanism of spinal cord injury-induced neuropathic pain.

Qiansheng Liang, MD, PhD 
Research Assistant and Laboratory Manager

My recent research has focused on 1) the structural basis of the modulation of Kv3 channels by novel positive allosteric modulators; and 2) the receptor mediated signaling mechanism that modulates inactivation gating of Kv3.4 channels, which is potentially implicated in peripheral mechanisms of pain. 

    Former Team Members

    Former Members Role in Lab Current Position
    Jennifer Miller Research Technician  
    Tapan Vyas, PhD Postdoctoral Fellow  
    Henry H Jerng, PhD Graduate Student (PhD) Assistant Professor, Baylor College of Medicine
    Edward J Beck, PhD Graduate Student (PhD)  
    Laura Escobar, PhD Postdoctoral Fellow Principal Investigator, UNAM, Mexico City
    Maria T Pacheco-Cano, PhD Postdoctoral Fellow  
    Mohammad Shahidullah, PhD Postdoctoral Fellow  
    Ivan Velasco, PhD Visiting Scholar Principal Investigator, UNAM, Mexico City
    Guangyu (Gary) Wang, PhD Postdoctoral Fellow  
    Ricardo H Pineda, PhD Postdoctoral Fellow Research Assistant Professor, University of Pittsburgh
    Thanawath Ratanadilok Na Phuket, PhD Graduate Student (PhD)  
    Andrew Graber Research Technician Physician
    Carmen A Rocha, MS, PA Graduate Student (MS) Physician Assistant
    Benjamin Kaplan, MD Graduate Student (MS) Physician
    Aditya Bhattacharji Research Assistant Veeva, Senior Director
    Nathan J Klett Undergraduate Student Researcher, Leiden University, Netherlands
    Kelly A Dougherty, PhD Graduate Student (PhD) Associate Professor, Rhodes College, Memphis, TN
    Yuri A Kaulin, PhD Research Assistant Professor  
    Jose A De Santiago-Castillo, PhD Postdoctoral Fellow  
    Annika F Barber Graduate Student (PhD) Assistant Professor, Rutgers University-Waksman Institute
    David M Ritter Graduate Student (MD/PhD) Assistant Professor, Child Neurology, Cincinnati Children's Hospital
    Jeffrey D Fineberg Graduate Student (PhD) Principal, Bluestar / BioAdvisors
    Benjamin Zemel Graduate Student (PhD) Assistant Professor, Ithaca College, NY
    Shelly T Jones Graduate Student (MS) Budget and Policy Analyst, Colorado Department of Human Services
    Brian Urbani Graduate Student (MS) Clinical Research Associate, PRA Health Sciences
    Tanziyah Muqeem Graduate Student (MD/PhD) Assistant Professor, Neurology, University of North Carolina Chapel Hill
    Elaine Yang Graduate Student (MD/PhD) Urology Resident, Cleveland Clinic
    Lianteng Zhi, PhD Postdoctoral Fellow Biostatistician, Christiana Care
    Andrew Sam Medical Student MD Candidate, SKMC