
Covarrubias Research
Contact
Position:
Professor
233 South 10th Street
BLSB 231
Philadelphia, PA 19107
Contact Number(s):
Highlighted Publications
- Covarrubias, M., Liang, Q., Nguyen-Phuong, L., Kennedy, K.J., Alexander, T.D., Sam, A. (2025). Structural insights into the function, dysfunction and modulation of Kv3 channels. Neuropharmacol. doi: 10.1016/j.neuropharm.2025.110483.
- Feng, H., Clatot, J., Kaneko, K., Flores-Mendez, M., Wengert, E.R., Koutcher, C., Hoddeson, E., Lopez, E., Lee, D., Arias, L., Liang, Q., Zhang, X., Somarowthu, A., Covarrubias, M., Gunthorpe, M.J., Large, C.H., Akizu, N., and Goldberg, E.M. (2024). Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy. Cell Rep Med 101389.
- Clatot, J., Currin, C.B., Liang, Q., Pipatpolkai, T., Massey, S.L., Helbig, I., Delemotte, L., Vogels, T.P., Covarrubias, M., and Goldberg, E.M. (2024). A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proc Natl Acad Sci USA 121: e2307776121.
- Liang, Q., Chi, G., Cirqueira, L., Zhi, L., Marasco, A., Pilati, N., Gunthorpe, M.J., Alvaro, G., Large, C.H., Sauer, D.B., Treptow W., and Covarrubias, M. (2024). The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun 15: 2533.
- Alexander, T.D., Tymanskyj, S., Kennedy, K.J., Kaczmarek, L.K., and Covarrubias, M. (2024). Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons. Proc Natl Acad Sci USA. 122: e2411033121.
- Barton, J., Londregan, A., Alexander, T., …Covarrubias, M. and Waldman, S. (2023). Intestinal neuropod cell GUCY2C regulates visceral pain. J Clin Invest 133(4):e165578.
- Londregan, A., Alexander, T.D., Covarrubias, M., and Waldman, S.A. (2023). Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain. J Neurochem 167: 719-732.
- Barton, J.R., Londregan, A.K., Alexander, T.D., Entezari, A.A., Covarrubias, M, and Waldman, S.A. (2023) Enteroendocrine cell regulation of the gut-brain axis. Front Neurosci 17: 1272955.
- Chi, G., Liang, Q., …Covarrubias, M. and Duerr, K. (2022). Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Nat. Commun. 13:4087.
- Alexander, T., Muqeem, T., Zhi, L., ...Covarrubias, M. (2022). Tunable action potential repolarization governed by Kv3.4 channels in DRG neurons. J. Neurosci. 42:8647-8657.
- Zemel, B.M., Zhi, L., Brown, E., Tymanskyj, S. and Covarrubias, M. (2021). PKCe associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner. FASEB J. 35(1):e21241.
- Ojala, K.S., Ginebaugh, S.P., Wu, M., Miller, E.W., Ortiz, G., Covarrubias, M., Meriney, S.D. (2021). A high affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J. Biol. Chem. 16:100302.
- Yang, E., Bu, W., Suma, A., …Eckenhoff, R.G. and Covarrubias, M. (2021). The propofol binding site of prokaryotic sodium channels. ACS Chem Neurosci 12: 3898-3914.
Publications
- Structural insights into the function, dysfunction and modulation of Kv3 channels
- Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons
- The binding and mechanism of a positive allosteric modulator of Kv3 channels
- Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy
- A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction
- Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain
- Intestinal neuropod cell GUCY2C regulates visceral pain
- Enteroendocrine cell regulation of the gut-brain axis
- Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain
- Tunable Action Potential Repolarization Governed by Kv3.4 Channels in Dorsal Root Ganglion Neurons
- Binding Sites and the Mechanism of Action of Propofol and a Photoreactive Analogue in Prokaryotic Voltage-Gated Sodium Channels
- PKCε associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner
- A high-Affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at nmjs
- Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation
- Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites
- A-Type KV Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction
- Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors
- Coupling of smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration
- Regulation of nociceptive glutamatergic signaling by presynaptic Kv3.4 channels in the rat spinal dorsal horn
- Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels