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Research
Research

Covarrubias Research

Contact

Manuel L. Covarrubias, MD, PhD
Professor

233 South 10th Street
BLSB 231
Philadelphia, PA 19107

Highlighted Publications

  • Covarrubias, M., Liang, Q., Nguyen-Phuong, L., Kennedy, K.J., Alexander, T.D., Sam, A. (2025). Structural insights into the function, dysfunction and modulation of Kv3 channels. Neuropharmacol. doi: 10.1016/j.neuropharm.2025.110483.
  • Feng, H., Clatot, J., Kaneko, K., Flores-Mendez, M., Wengert, E.R., Koutcher, C., Hoddeson, E., Lopez, E., Lee, D., Arias, L., Liang, Q., Zhang, X., Somarowthu, A., Covarrubias, M., Gunthorpe, M.J., Large, C.H., Akizu, N., and Goldberg, E.M. (2024). Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy. Cell Rep Med 101389.
  • Clatot, J., Currin, C.B., Liang, Q., Pipatpolkai, T., Massey, S.L., Helbig, I., Delemotte, L., Vogels, T.P., Covarrubias, M., and Goldberg, E.M. (2024). A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proc Natl Acad Sci USA 121: e2307776121.
  • Liang, Q., Chi, G., Cirqueira, L., Zhi, L., Marasco, A., Pilati, N., Gunthorpe, M.J., Alvaro, G., Large, C.H., Sauer, D.B., Treptow W., and Covarrubias, M. (2024). The binding and mechanism of a positive allosteric modulator of Kv3 channels. Nat Commun 15: 2533.
  • Alexander, T.D., Tymanskyj, S., Kennedy, K.J., Kaczmarek, L.K., and Covarrubias, M. (2024). Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons. Proc Natl Acad Sci USA. 122: e2411033121.
  • Barton, J., Londregan, A., Alexander, T., …Covarrubias, M. and Waldman, S. (2023). Intestinal neuropod cell GUCY2C regulates visceral pain. J Clin Invest 133(4):e165578.
  • Londregan, A., Alexander, T.D., Covarrubias, M., and Waldman, S.A. (2023). Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain. J Neurochem 167: 719-732.
  • Barton, J.R., Londregan, A.K., Alexander, T.D., Entezari, A.A., Covarrubias, M, and Waldman, S.A. (2023) Enteroendocrine cell regulation of the gut-brain axis. Front Neurosci 17: 1272955.
  • Chi, G., Liang, Q., …Covarrubias, M. and Duerr, K. (2022). Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Nat. Commun. 13:4087.
  • Alexander, T., Muqeem, T., Zhi, L., ...Covarrubias, M. (2022). Tunable action potential repolarization governed by Kv3.4 channels in DRG neurons. J. Neurosci. 42:8647-8657.
  • Zemel, B.M., Zhi, L., Brown, E., Tymanskyj, S. and Covarrubias, M. (2021). PKCe associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner. FASEB J. 35(1):e21241.
  • Ojala, K.S., Ginebaugh, S.P., Wu, M., Miller, E.W., Ortiz, G., Covarrubias, M., Meriney, S.D. (2021). A high affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. J. Biol. Chem. 16:100302.
  • Yang, E., Bu, W., Suma, A., …Eckenhoff, R.G. and Covarrubias, M. (2021). The propofol binding site of prokaryotic sodium channels. ACS Chem Neurosci 12: 3898-3914.

Publications

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