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Research
Research
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Choi Research

Contact

Jason Choi, PhD
Assistant Professor of Medicine, Division of Cardiology
Department of Medicine

1020 Locust Street
JAH, Room 236
Philadelphia, PA 19107

Publications

Recent Publications

Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of function LMNA mutation

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy

Med25 Limits Master Regulators That Govern Adipogenesis

Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival

Nuclear envelope regulation of signaling cascades

Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation

Reactivation of autophagy ameliorates LMNA cardiomyopathy

Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation

Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation

Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins

Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins

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