Publications

Contact

Name: David Abraham, PhD
Position: Professor

233 10th Street
530 BLSB
Philadelphia, PA 19107

Telephone: 215-503-8917

Highlighted Publications

Bonne-Année, S.,  L. A. Kerepesi, J.A. Hess,  J. Wesolowski, F. Paumet, J.B. Lok, T. J. Nolan, and D. Abraham. 2014.  Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis. Microbes and Infection.  16:502-511.

This study demonstrated a novel mechanism utilized by human and mouse neutrophils to kill larval S. stercoralis. DNA based extracellular traps are released by neutrophils that ensnare parasite and thereby impede parasite movement and thus allow cells to come into contact with the worms and kill them.

Hess, J.A.,  B. Zhan, S. Bonne-Année, J. Deckman,  M. E. Bottazzi, P. J. Hotez, T. R. Klei, S. Lustigman and  D. Abraham.  2014. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. International Journal for Parasitology 44: 637-646.

Recombinant antigen vaccine candidates were tested in mice and three were identified that were shown to reproducibly induce protective immunity when administered individually, as fusion proteins or in combination, thus making these antigens strong candidates for inclusion in a vaccine to control onchocerciasis in humans.

Hess , J.A., B. Zhan, A.R. Torigian, J.B. Patton, N. Petrovsky, T. Zhan, M.E. Bottazzi, P.J. Hotez, T.R. Klei, S. Lustigman and  D. Abraham. 2016. The immunomodulatory role of adjuvants in vaccines formulated with the recombinant antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in mice. PLoS Neglected Tropical Diseases, 10: e0004797

Immunizing mice with two recombinant antigens in conjunction with the adjuvants alum, Advax 2 and MF59 induced significant levels of larval killing. The mechanism of protective immunity induced by these vaccines appears to be multifactorial with roles for cytokines, chemokines, antibody and specific effector cells.

Patton, J.B., S. Bonne-Année, J. Deckman, J.A. Hess, A. Torigian, T.J. Nolan, Z. Wang, S.A. Kliewer, A.C. Durham, J.J. Lee, M.L. Eberhard, D. J. Mangelsdorf, J. B. Lok, and D. Abraham. 2018. Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice.  Proceedings of the National Academy of Sciences of the United States of America.  115: 204–209.

NSG mice, which have a reduced innate immune response and lack adaptive immunity, develop a complete infection with S. stercoralis and hyperinfection if treated with steroids. Treatment with Δ7-dafachronic acid, an agonist of the parasite nuclear receptor Ss-DAF-12, significantly reduced the worm burden in mice undergoing hyperinfection with S. stercoralis

Recent Publications

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Advances in vascular medicine

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Epithelial cells promote fibroblast activation via IL-1α in systemic sclerosis

Review of the role of erythropoietin in critical leg ischemia

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma

Angiogenic effects of stromal cell-derived factor-1 (SDF-1/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia

Lymphatic and blood vessels in scleroderma skin, a morphometric analysis

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts

Loss of β1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model

Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

JunB mediates enhancer/promoter activity of COL1A2 following TGF-β induction

Neuronal regulators and vascular dysfunction in Raynaud's phenomenon and systemic sclerosis

Pericytes display increased CCN2 expression upon culturing

Cross-talk between MCP-3 and TGFβ promotes fibroblast collagen biosynthesis

Interior flood hydrographs from stopped-clocks

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.