Publications

Contact

Name: David Abraham, PhD
Position: Professor

233 10th Street
530 BLSB
Philadelphia, PA 19107

Telephone: 215-503-8917

Highlighted Publications

Bonne-Année, S.,  L. A. Kerepesi, J.A. Hess,  J. Wesolowski, F. Paumet, J.B. Lok, T. J. Nolan, and D. Abraham. 2014.  Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis. Microbes and Infection.  16:502-511.

This study demonstrated a novel mechanism utilized by human and mouse neutrophils to kill larval S. stercoralis. DNA based extracellular traps are released by neutrophils that ensnare parasite and thereby impede parasite movement and thus allow cells to come into contact with the worms and kill them.

Hess, J.A.,  B. Zhan, S. Bonne-Année, J. Deckman,  M. E. Bottazzi, P. J. Hotez, T. R. Klei, S. Lustigman and  D. Abraham.  2014. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. International Journal for Parasitology 44: 637-646.

Recombinant antigen vaccine candidates were tested in mice and three were identified that were shown to reproducibly induce protective immunity when administered individually, as fusion proteins or in combination, thus making these antigens strong candidates for inclusion in a vaccine to control onchocerciasis in humans.

Hess , J.A., B. Zhan, A.R. Torigian, J.B. Patton, N. Petrovsky, T. Zhan, M.E. Bottazzi, P.J. Hotez, T.R. Klei, S. Lustigman and  D. Abraham. 2016. The immunomodulatory role of adjuvants in vaccines formulated with the recombinant antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in mice. PLoS Neglected Tropical Diseases, 10: e0004797

Immunizing mice with two recombinant antigens in conjunction with the adjuvants alum, Advax 2 and MF59 induced significant levels of larval killing. The mechanism of protective immunity induced by these vaccines appears to be multifactorial with roles for cytokines, chemokines, antibody and specific effector cells.

Patton, J.B., S. Bonne-Année, J. Deckman, J.A. Hess, A. Torigian, T.J. Nolan, Z. Wang, S.A. Kliewer, A.C. Durham, J.J. Lee, M.L. Eberhard, D. J. Mangelsdorf, J. B. Lok, and D. Abraham. 2018. Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice.  Proceedings of the National Academy of Sciences of the United States of America.  115: 204–209.

NSG mice, which have a reduced innate immune response and lack adaptive immunity, develop a complete infection with S. stercoralis and hyperinfection if treated with steroids. Treatment with Δ7-dafachronic acid, an agonist of the parasite nuclear receptor Ss-DAF-12, significantly reduced the worm burden in mice undergoing hyperinfection with S. stercoralis

Recent Publications

Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice

Author Correction: Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance (Scientific Reports, (2019), 9, 1, (19889), 10.1038/s41598-019-56496-7)

Human t-cell leukemia virus type 1 and strongyloides stercoralis: Partners in pathogenesis

Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism

Defining genetic risk factors for scleroderma-associated interstitial lung disease: IRF5 and STAT4 gene variants are associated with scleroderma while STAT4 is protective against scleroderma-associated interstitial lung disease

Hyperglycaemia and Ischaemia Impair Wound Healing via Toll-like Receptor 4 Pathway Activation in vitro and in an Experimental Murine Model

Serum markers of pulmonary epithelial damage in systemic sclerosis-associated interstitial lung disease and disease progression

Altered cyclooxygenase-1 and enhanced thromboxane receptor activities underlie attenuated endothelial dilatory capacity of omental arteries in obesity: COX-mediated endothelial dysfunction in obesity

Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance

Toll-like receptors 2 and 6 mediate apoptosis and inflammation in ischemic skeletal myotubes

Stem cell enriched lipotransfer reverses the effects of fibrosis in systemic sclerosis

Metabolic profiling of elite athletes with different cardiovascular demand

Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling

Type I collagen structure, synthesis, and regulation

Proteomics and metabolomics research in exercise and sport

Functional and phenotypic heterogeneity of Th17 cells in health and disease

Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans

Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) within a polysaccharide galactomannan matrix have potential for wound healing

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum

Insights into myofibroblasts and their activation in scleroderma: Opportunities for therapy?

Bed-load measurements on large, sand-bed rivers in the United States

Molecular Basis for Dysregulated Activation of NKX2-5 in the Vascular Remodeling of Systemic Sclerosis

Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk

Chemokines in systemic sclerosis

Association of Defective Regulation of Autoreactive Interleukin-6–Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis