Hushan Yang Research

Contact

Name: Hushan Yang, PhD
Position: Professor

1025 Walnut Street
Suite 727
Philadelphia, PA 19107

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Highlighted Publications

Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB, Wu X. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res. 2008 Apr 1; 68(7):2530-7.

Hildebrandt MA, Yang H, Hung M, Izzo J, Huang M, Lin J, Ajani JA, Wu X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes following chemoradiation for patients with esophageal cancer. J Clin Oncol. 2009 Feb 20; 27(6):857-71.

Mu Z, Wang C, Ye Z, Austin L, Civan J, Hyslop T, Palazzo JP, Jaslow R, Li B, Myers RE, Jiang J, Yang H, Cristofanilli, M. Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer. Breast Cancer Res Treat. 2015 Dec;154(3):563-71.

Li J, Huang Q, Long X, Zhang J, Huang X, Aa J, Yang H, Chen Z, Xing J. CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways. J Hepatol. 2015 Dec;63(6):1378-89

Lai Y, Wang C, Civan JM, Palazzo JP, Ye Z, Hyslop T, Lin J, Myers RE, Li B, Jiang B, Sama A, Xing J, Yang H. Effects of Cancer Stage and Treatment Differences on Racial Disparities in Survival from Colon Cancer: A United States Population-Based Study. Gastroenterology. 2016 May;150(5):1135-46.

Wang C, Mu Z, Chervoneva I, Austin L, Ye Z, Rossi G, Palazzo JP, Sun C, Abu-Khalaf M, Myers RE, Zhu Z, Ba Y, Li B, Hou L, Cristofanilli M, Yang H. Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer. Breast Cancer Res Treat. 2017 Jan;161(1):83-94.

Wei Q, Ye Z, Zhong X, Li L, Wang C, Myers RE, Palazzo JP, Fortuna D, Yan A, Waldman SA, Chen X, Posey J, Basu-Ballick A, Jiang BH, Hou L, Shu J, Sun J, Xing J, Li B, Yang H. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis. Ann Oncol. 2017 July; 28: 2135-2141.

Ye Z, Wang C, Wan S, Mu Z, Zhang Z, Abu-Khalaf MM, Fellin FM, Silver DP, Neupane M, Jaslow RJ, Bhattacharya S, Tsangaris TN, Chervoneva I, Berger A, Austin L, Palazzo JP, Myers RE, Pancholy N, Toorkey D, Yao K, Krall M, Li X, Chen X, Fu X, Xing J, Hou L, Wei Q, Li B, Cristofanilli M, Yang H. Association of clinical outcomes in metastatic breast cancer patients with circulating tumor cell and circulating cell-free DNA. Eur J Cancer, 2019 Jan;106:133-143.

Yin C, Li D, Guo X, Cao H, Chen Y, Zhou F, Ge N, Liu Y, Guo S, Zhao Z, Yang H, Xing J. NGS-based profiling reveals a critical contributing role of somatic D-loop mtDNA mutations in HBV-related hepatocarcinogenesis. Ann Oncol. 2019 Mar 18. pii: mdz105. doi: 10.1093.

Bohlius J, Bohlke K, Castelli R, Djulbegovic B, Lustberg MB, Martino M, Mountzios G, Peswani N, Porter L, Tanaka TN, Trifirò G, Yang H, Lazo-Langner A. Management of Cancer-Associated Anemia With Erythropoiesis-Stimulating Agents: ASCO/ASH Clinical Practice Guideline Update. J Clin Oncol. 2019 May;37(15):1336-1351.    

Recent Publications

Potentially functional genetic variants in KDR gene as prognostic markers in patients with resected colorectal cancer

A meta-analysis of array-CGH studies implicates antiviral immunity pathways in the development of hepatocellular Carcinoma

Longer leukocyte telomere length predicts increased risk of hepatitis b virus-related hepatocellular carcinoma: A case-control analysis

Association of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population

Association between mitochondrial DNA content in leukocytes and colorectal cancer risk

GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis

Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients

New strategy for large-scale preparation of the extracellular domain of tumor-associated antigen HAb18G/CD147 (HAb18GED)

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer

Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma

Genetic variation in microRNA genes and risk of oral premalignant lesions

Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays

Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk

MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma

Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: Large-scale evaluation of genetic variants

HAb18G/CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 down-regulation

Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions

Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy

Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma

Genetic variations in MicroRNA-related genes are novel susceptibility loci for esophageal cancer risk

Genetic susceptibility to renal cell carcinoma: The role of DNA double-strand break repair pathway

Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions

Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer