Publications

Contact

Name: Hushan Yang, PhD
Position: Professor

1025 Walnut Street
Suite 727
Philadelphia, PA 19107

Telephone: 215-503-6521

Highlighted Publications

Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB, Wu X. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res. 2008 Apr 1; 68(7):2530-7.

Hildebrandt MA, Yang H, Hung M, Izzo J, Huang M, Lin J, Ajani JA, Wu X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes following chemoradiation for patients with esophageal cancer. J Clin Oncol. 2009 Feb 20; 27(6):857-71.

Mu Z, Wang C, Ye Z, Austin L, Civan J, Hyslop T, Palazzo JP, Jaslow R, Li B, Myers RE, Jiang J, Yang H, Cristofanilli, M. Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer. Breast Cancer Res Treat. 2015 Dec;154(3):563-71.

Li J, Huang Q, Long X, Zhang J, Huang X, Aa J, Yang H, Chen Z, Xing J. CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways. J Hepatol. 2015 Dec;63(6):1378-89

Lai Y, Wang C, Civan JM, Palazzo JP, Ye Z, Hyslop T, Lin J, Myers RE, Li B, Jiang B, Sama A, Xing J, Yang H. Effects of Cancer Stage and Treatment Differences on Racial Disparities in Survival from Colon Cancer: A United States Population-Based Study. Gastroenterology. 2016 May;150(5):1135-46.

Wang C, Mu Z, Chervoneva I, Austin L, Ye Z, Rossi G, Palazzo JP, Sun C, Abu-Khalaf M, Myers RE, Zhu Z, Ba Y, Li B, Hou L, Cristofanilli M, Yang H. Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer. Breast Cancer Res Treat. 2017 Jan;161(1):83-94.

Wei Q, Ye Z, Zhong X, Li L, Wang C, Myers RE, Palazzo JP, Fortuna D, Yan A, Waldman SA, Chen X, Posey J, Basu-Ballick A, Jiang BH, Hou L, Shu J, Sun J, Xing J, Li B, Yang H. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis. Ann Oncol. 2017 July; 28: 2135-2141.

Ye Z, Wang C, Wan S, Mu Z, Zhang Z, Abu-Khalaf MM, Fellin FM, Silver DP, Neupane M, Jaslow RJ, Bhattacharya S, Tsangaris TN, Chervoneva I, Berger A, Austin L, Palazzo JP, Myers RE, Pancholy N, Toorkey D, Yao K, Krall M, Li X, Chen X, Fu X, Xing J, Hou L, Wei Q, Li B, Cristofanilli M, Yang H. Association of clinical outcomes in metastatic breast cancer patients with circulating tumor cell and circulating cell-free DNA. Eur J Cancer, 2019 Jan;106:133-143.

Yin C, Li D, Guo X, Cao H, Chen Y, Zhou F, Ge N, Liu Y, Guo S, Zhao Z, Yang H, Xing J. NGS-based profiling reveals a critical contributing role of somatic D-loop mtDNA mutations in HBV-related hepatocarcinogenesis. Ann Oncol. 2019 Mar 18. pii: mdz105. doi: 10.1093.

Bohlius J, Bohlke K, Castelli R, Djulbegovic B, Lustberg MB, Martino M, Mountzios G, Peswani N, Porter L, Tanaka TN, Trifirò G, Yang H, Lazo-Langner A. Management of Cancer-Associated Anemia With Erythropoiesis-Stimulating Agents: ASCO/ASH Clinical Practice Guideline Update. J Clin Oncol. 2019 May;37(15):1336-1351.    

Recent Publications

Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors

An Effective Strategy to Eliminate Inherent Cross-Contamination in mtDNA Next-Generation Sequencing of Multiple Samples

NGS-based profiling reveals a critical contributing role of somatic D-loop mtDNA mutations in HBV-related hepatocarcinogenesis

Management of cancer-associated anemia with erythropoiesis-stimulating agents: ASCO/ASH clinical practice guideline update

Management of cancer-associated anemia with erythropoiesis-stimulating agents: ASCO/ASH clinical practice guideline update

Association of clinical outcomes in metastatic breast cancer patients with circulating tumour cell and circulating cell-free DNA

A routine laboratory data-based model for predicting recurrence after curative resection of stage II colorectal cancer

Multi-regional sequencing reveals intratumor heterogeneity and positive selection of somatic mtDNA mutations in hepatocellular carcinoma and colorectal cancer

DNA methylation of telomere-related genes and cancer risk

Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort

MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation

TNFα induces Ca 2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells

Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations

MCU-dependent mitochondrial Ca 2+ inhibits NAD +/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer

Prognostic values of cancer associated macrophage-like cells (CAML) enumeration in metastatic breast cancer

Genetic variations of mitochondrial genome modify risk and prognosis of hepatocellular carcinoma patients

Cancer driver gene discovery through an integrative genomics approach in a non-parametric Bayesian framework

Heparin promotes cardiac differentiation of human pluripotent stem cells in chemically defined albumin-free medium, enabling consistent manufacture of cardiomyocytes

Prospective and longitudinal evaluations of telomere length of circulating DNA as a risk predictor of hepatocellular carcinoma in HBV patients