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Xin-Liang Ma Research

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Name: Xin-Liang Ma, MD, PhD
Position: Professor

1025 Walnut Street
College Building, Room 808
Philadelphia, PA 19107

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Highlighted Publications

Tao L, Jiao XY, Gao ER, Lau W, Lopez BL, Christopher TA, Rao S, William W, Southan G, Sharma K, Koch WJ, Ma XL. Nitrative Inactivation of Thioredoxin-1 and Its Role in Post-Ischemic Myocardial Apoptosis. Circulation. 2006 Sep 26;114(13):1395-402.

Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation. 2009 Feb 17;119(6):835-44.

Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X, Wang Y, Shang X, Gao E, Koch WJ, Ma XL. C1q/TNF-Related Protein-3, a Newly Identified Adipokine, Is a Novel Anti-Apoptotic, Pro-Angiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart. Circulation.  2012 Jun 26;125(25):3159-69.

Sun Y, Yi W, Yuan Y, Lau WB, Yi D, Wang X, Wang Y, Su H, Wang X, Gao E, Koch WJ, Ma XL. C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation. Circulation. 2013 Sep 10;128(26 Suppl 1):S113-20. doi: 10.1161/CIRCULATIONAHA.112.000010.

Wang Y, Gao E, Lau WB, Wang Y, Liu G, Li JJ, Wang X, Yuan Y, Koch WJ, Ma XL. GRK2-Mediated Desensitization of AdipoR1 in Failing Heart. Circulation. 2015 Apr 21;131(16):1392-404. doi: 10.1161/CIRCULATIONAHA.114.015248. Epub 2015 Feb 18.

Recent Publications

Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury

COVID-19 and cardiovascular complications: Updates of emergency medicine

Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice

Prognostic Implications of OSA in Acute Coronary Syndrome by Obesity Status

Rationale and design of the RESTORE trial: A multicenter, randomized, double-blinded, parallel-group, placebo-controlled trial to evaluate the effect of Shenfu injection on myocardial injury in STEMI patients after primary PCI

Adiponectin-mediated promotion of CD44 suppresses diabetic vascular inflammatory effects

Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals

Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome

Epigenetic alterations of CXCL5 in Cr(VI)-induced carcinogenesis

Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure

Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease

C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood–Retinal Barrier Tight Junctions

Corrigendum: Utility of S100A12 as an Early Biomarker in Patients With ST-Segment Elevation Myocardial Infarction(Front. Cardiovasc. Med., (2021), 8, (747511), 10.3389/fcvm.2021.747511)

Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function

Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction

A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques

Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis

The Liver and Heart: How the Two Most Beloved “Babies” in the Human Body Communicate

HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis

Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

"know Diabetes by Heart": Role of adipocyte-cardiomyocyte communications

Macrophages in Ischemic Heart Failure: Yesterday, Today, and Tomorrow

Nicotine aggravates vascular adiponectin resistance via ubiquitin-mediated adiponectin receptor degradation in diabetic Apolipoprotein E knockout mouse

Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production

Development and validation of a risk score using complete blood count to predict in-hospital mortality in COVID-19 patients