Name: Xin-Liang Ma, MD, PhD
Position: Professor

1025 Walnut Street
College Building, Room 808
Philadelphia, PA 19107

Telephone: 215-955-4994

Highlighted Publications

Tao L, Jiao XY, Gao ER, Lau W, Lopez BL, Christopher TA, Rao S, William W, Southan G, Sharma K, Koch WJ, Ma XL. Nitrative Inactivation of Thioredoxin-1 and Its Role in Post-Ischemic Myocardial Apoptosis. Circulation. 2006 Sep 26;114(13):1395-402.

Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation. 2009 Feb 17;119(6):835-44.

Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X, Wang Y, Shang X, Gao E, Koch WJ, Ma XL. C1q/TNF-Related Protein-3, a Newly Identified Adipokine, Is a Novel Anti-Apoptotic, Pro-Angiogenic, and Cardioprotective Molecule in the Ischemic Mouse Heart. Circulation.  2012 Jun 26;125(25):3159-69.

Sun Y, Yi W, Yuan Y, Lau WB, Yi D, Wang X, Wang Y, Su H, Wang X, Gao E, Koch WJ, Ma XL. C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation. Circulation. 2013 Sep 10;128(26 Suppl 1):S113-20. doi: 10.1161/CIRCULATIONAHA.112.000010.

Wang Y, Gao E, Lau WB, Wang Y, Liu G, Li JJ, Wang X, Yuan Y, Koch WJ, Ma XL. GRK2-Mediated Desensitization of AdipoR1 in Failing Heart. Circulation. 2015 Apr 21;131(16):1392-404. doi: 10.1161/CIRCULATIONAHA.114.015248. Epub 2015 Feb 18.

Recent Publications

Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury

C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality

The role of NO-cGMP pathway inhibition in vascular endothelial-dependent smooth muscle relaxation disorder of AT1-AA positive rats: protective effects of adiponectin

Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling

Association of obstructive sleep apnea with C ardiovascular outcomes in patients with acute coronary syndrome

Withaferin a prevents myocardial ischemia/reperfusion injury by upregulating AMP-activated protein kinase-dependent B-cell lymphoma2 signaling

Active immunization using hand-push emulsification method increases the operator's risk of transcutaneous immunization

Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress

The contribution of chronic intermittent hypoxia to OSAHS: From the perspective of serum extracellular microvesicle proteins

Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis article

PD-1 Modulates Radiation-Induced Cardiac Toxicity through Cytotoxic T Lymphocytes

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury

Endothelial Cell-Derived Microparticles from Patients with Obstructive Sleep Apnea Hypoxia Syndrome and Coronary Artery Disease Increase Aortic Endothelial Cell Dysfunction

C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways

Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling

Response by Du et al to letter regarding article, “Cardiac fibroblast-specific activating transcription factor 3 protects against heart failure by Suppressing MAP2K3-p38 signaling”

Adiponectin improves coronary no-reflow injury by protecting the endothelium in rats with type 2 diabetes mellitus

Danshen-Chuanxiong-Honghua ameliorates cerebral impairment and improves spatial cognitive deficits after transient focal ischemia and identification of active compounds

MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70

Cardiovascular Adiponectin Resistance: The Critical Role of Adiponectin Receptor Modification

Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart

Cardiac fibroblast-specific activating transcription factor 3 protects against heart failure by suppressing MAP2K3-p38 signaling

Pharmacokinetic study of representative anti-oxidative compounds from Denshen-Chuanxiong-Honghua following oral administration in rats

T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity