Sykulev Research

Contact

Position: Professor

233 South 10th Street
Bluemle Life Sciences Building 706
Philadelphia, PA 19107

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Highlighted Publications

Anikeeva, N., Lebedeva, T., Krogsgaard, M., Tetin, S. Y., Martinez-Hackert, E., Kalams, S., Davis, M.M., and Sykulev, Y. (2003). Distinct molecular mechanisms account for the specificity of two different T-cell receptors. Biochemistry, 42:4709-4716.

Anikeeva, N., Lebedeva, T., Clapp, A. R., Goldman, E. R., Dustin, M. L., Mattoussi, H., and Sykulev, Y. (2006) Quantum Dot/Peptide-MHC Biosensors reveal strong CD8-dependent Cooperation Between Self and Viral Antigens that Augment the T Cell Response, Proc. Natl. Acad. Sci. USA, 103: 16846-16851.

Beal, A.M., Anikeeva, N., Varma, R., Cameron, T.O., Vasiliver-Shamis, G., Norris, P.J., Dustin, M.L., and Sykulev, Y. (2009). Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity, 31: 632-642 (PMID: 1983308).

Sykulev, Y. (2010) T cell receptor signaling kinetics takes the stage, Sci Signal. 2010, 3: pe50

Anikeeva, N. and Sykulev, Y. (2011) Mechanisms Controlling Granule-mediated Cytolytic Activity of Cytotoxic T Lymphocytes, Immunol Res., 51: 183-94

Steblyanko, M, Anikeeva, N, Campbell, KS, Keen, JH, Sykulev Y. (2015) Integrin signaling influences the size and dynamics of activating receptor microclusters in a Pyk2-dependent manner, J. Biol. Chem., 290:11833-42 (PMID: 25778396)

Anikeeva, N., Grosso, D., Flomenberg, N., Sykulev, Y. (2016) Evaluating frequency and quality of pathogen-specific T cells, Nat Commun, 7:13264 (PMID: 27786275)

Buggert, M., Nguyen, S., McLane, L.M., Steblyanko, M., Anikeeva, N., Paquin-Proulx, D., Estrada, P.M. Del Rio, Ablanedo-Terrazas, Y., Noyan, K., Morgan, A.R., Demers, K., Sandberg, J., Eller, M.A., Streeck, H., Jansson, M., Nowak, P., Sonnerborg, A., Canaday, D.H., Naji, A., Wherry, E.J., Robb, M., Deeks, S.G., Reyes-Teran, G., Sykulev, Y, Karlsson, A.C., Betts, M.R. (2018) Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease, PLoS Pathogens, 14: e1006973

Nadia Anikeeva, Nicholas Fischer, Craig Blanchette and Yuri Sykulev (2019) Extent of MHC clustering regulates selectivity and effectiveness of T-cell responses, J. Immunol., 202: 591-597

Nicholas Maskalenko, Shubhankar Nath, Adarsh Ramakrishnan, Nadia Anikeeva, Yuri Sykulev, Martin Poenie (2020) The DISC1-Girdin complex: A missing link in signaling to the T cell cytoskeleton, J Cell Sci, 133:jcs242875