Srivastava Research
1020 Locust Street
Jefferson Alumni Hall, Suite 394A
Philadelphia, PA 19107
Platelet-derived-Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock. Sci. Rep. 9: 17676, 2019.
We demonstrated that platelet-derived-extracellular vesicles improved the outcome following severe trauma by maintaining hemodynamic stability and attenuating the development of ischemia, base deficit, and cardiovascular shock.
Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro. Regen. Med. 14:295-307, 2019.
In this study, after experimental TBI, we observed systemic infusions of human umbilical cord blood cells improved brain vascular integrity by reducing blood-brain-barrier leakage.
Inflammation-stimulated mesenchymal stromal cell-derived extracellular vesicles attenuate inflammation. Stem Cells. 36:79-90, 2018.
In this study, we used a highly scalable and current Good Manufacturing Practice (cGMP)--compliant tangential flow filtration system to isolate EVs based on size. We observed that MSCs stimulated with proinflammatory cytokines to produce EVs with heightened immunomodulatory potential, an observation important to improve efficacy for future clinical application.
Publications
- Recovery after human bone marrow mesenchymal stem cells (hBM-MSCs)-derived extracellular vesicles (EVs) treatment in post-MCAO rats requires repeated handling
- Most recent advances and applications of extracellular vesicles in tackling neurological challenges
- Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- PET imaging of microglia using PBR28suv determines therapeutic efficacy of autologous bone marrow mononuclear cells therapy in traumatic brain injury
- Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability
- Editorial: Glia-Mediated Neurotoxicity: Uncovering the Molecular Mechanisms
- Role of Extracellular Vesicles in Glia-Neuron Intercellular Communication
- Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
- PET Imaging of Peripheral Benzodiazepine Receptor Standard Uptake Value Increases After Controlled Cortical Impact, a Rodent Model of Traumatic Brain Injury
- High-resolution and differential analysis of rat microglial markers in traumatic brain injury: conventional flow cytometric and bioinformatics analysis
- Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock
- Regulation of endothelial cell permeability by platelet-derived extracellular vesicles
- Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro
- Current Approaches to Tissue Engineering of the Nervous System
- Current approaches to tissue engineering of the nervous system
- Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modify Microglial Response and Improve Clinical Outcomes in Experimental Spinal Cord Injury
- Teriflunomide Modulates Vascular Permeability and Microglial Activation after Experimental Traumatic Brain Injury
- Platelet-derived microvesicles: A potential therapy for trauma-induced coagulopathy
- Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma
- Traumatic brain injury