Srivastava Research


Name: Amit K. Srivastava, PhD

1020 Locust Street
Jefferson Alumni Hall. Suite 394.A
Philadelphia, PA 19107

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Platelet-derived-Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock. Sci. Rep. 9: 17676, 2019.

We demonstrated that platelet-derived-extracellular vesicles improved the outcome following severe trauma by maintaining hemodynamic stability and attenuating the development of ischemia, base deficit, and cardiovascular shock.

Human umbilical cord blood cells restore vascular integrity in injured rat brain and modulate inflammation in vitro. Regen. Med. 14:295-307, 2019.

In this study, we observed that systemic infusions of human umbilical cord blood cells improved brain vascular integrity by reducing the blood-brain-barrier leakage after experimental TBI.

Inflammation-stimulated mesenchymal stromal cell-derived extracellular vesicles attenuate inflammation. Stem Cells. 36:79-90, 2018.

In this study, we used a highly scalable and current Good Manufacturing Practice (cGMP)-compliant tangential flow filtration system to isolate EVs based on their size. We observed that MSCs stimulated with proinflammatory cytokines to produce EVs with heightened immunomodulatory potential, an observation important to improve efficacy for future clinical application.