Luis Sigal, DMV, PhD


Name: Luis Sigal, DMV, PhD
Position: Associate Professor

233 South Tenth Street
Bluemle Life Sciences Building, Room 709
Philadelphia, PA 19107

Telephone: 215-503-4535

Highlighted Publications

Recent Publications

Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation

STING sensing of murine cytomegalovirus alters the tumor microenvironment to promote antitumor immunity

α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control

Chronic lymphocytic choriomeningitis infection causes susceptibility to mousepox and impairs natural killer cell maturation and function

Loss of resistance to mousepox during chronic lymphocytic choriomeningitis virus infection is associated with impaired T-cell responses and can be rescued by immunization

Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node

Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding

Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node

With some risk-taking and luck: A veterinarian’s adventures in viral immunology

Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

Activation of CD8 T Lymphocytes during Viral Infections

The Pathogenesis and Immunobiology of Mousepox

The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment

Protective CD8+ T cell memory without help

CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization

Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection

Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth

Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses

MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve toll-like receptor 2

Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection

Immunology: Memory cells sound the alarm

Memory CD8+ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection

Getting in front and behind the enemy lines to counter virus infection