Contact
233 South Tenth Street
Bluemle Life Sciences Building, Room 709
Philadelphia, PA 19107
Highlighted Publications
Xu RH, Wong EB, Rubio D, Roscoe F, Ma X, Nair S, Remakus S, Schwendener R, John S, Shlomchik M, and Sigal LJ. (2015) Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection. Immunity. 2015 Dec 15;43(6):1148-59. PubMed PMID: 26682986. (PDF)
Rubio D, Xu RH, Remakus S, Krouse TE, Truckenmiller ME, Thapa RJ, Balachandran S, Alcamí A, Norbury CC, and Sigal LJ. (2013) Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection. Cell Host Microbe. 2013 Jun 12;13(6):701-10. PubMed PMID: 23768494. (PDF)
Fang M, Lanier LL, and Sigal LJ. (2008) A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLoS Pathog. 2008 Feb 8;4(2):e30. PubMed PMID: 18266471. (PDF)
Fang M, Roscoe F, and Sigal LJ. (2010) Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking. J Exp Med. 2010 Oct 25;207(11):2369-81. PubMed PMID: 20876312. (PDF)
Fang M, Siciliano NA, Hersperger AR, Roscoe F, Hu A, Ma X, Shamsedeen AR, Eisenlohr LC, and Sigal LJ. (2012) Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9983-8. PubMed PMID: 22665800. (PDF)
Publications
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
- Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine
- Interferon partly dictates a divergent transcriptional response in poxvirus-infected and bystander inflammatory monocytes
- Mechanisms of antiviral cytotoxic cd4 t cell differentiation
- Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection
- IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells
- Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing
- Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells
- Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging
- Dysregulated Anti-Viral Innate Immune Cascade During Aging
- Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation
- STING sensing of murine cytomegalovirus alters the tumor microenvironment to promote antitumor immunity
- α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control
- Chronic lymphocytic choriomeningitis infection causes susceptibility to mousepox and impairs natural killer cell maturation and function
- Loss of resistance to mousepox during chronic lymphocytic choriomeningitis virus infection is associated with impaired T-cell responses and can be rescued by immunization
- Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node
- Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy
- A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding