Sigal Research
Contact
Name:
Luis Sigal, DVM, PhD
Position:
Professor
233 South Tenth Street
Bluemle Life Sciences Building, Room 709
Philadelphia, PA 19107
Email:
Luis.Sigal@jefferson.edu
Contact Number(s):
Publications
- The roles of CD4+ T cell help, sex, and dose in the induction of protective CD8+ T cells against a lethal poxvirus by mRNA-LNP vaccines
- Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
- mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
- Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
- Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice
- Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL
- Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine
- Interferon partly dictates a divergent transcriptional response in poxvirus-infected and bystander inflammatory monocytes
- Mechanisms of antiviral cytotoxic cd4 t cell differentiation
- Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection
- IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells
- Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing
- Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells
- Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging
- Dysregulated Anti-Viral Innate Immune Cascade During Aging
- Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation
- STING sensing of murine cytomegalovirus alters the tumor microenvironment to promote antitumor immunity
- α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control
- Chronic lymphocytic choriomeningitis infection causes susceptibility to mousepox and impairs natural killer cell maturation and function
- Loss of resistance to mousepox during chronic lymphocytic choriomeningitis virus infection is associated with impaired T-cell responses and can be rescued by immunization