Sigal Research

Contact

Name: Luis Sigal, DMV, PhD
Position: Professor

233 South Tenth Street
Bluemle Life Sciences Building, Room 709
Philadelphia, PA 19107

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Highlighted Publications

Recent Publications

Mechanisms of antiviral cytotoxic cd4 t cell differentiation

Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection

IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells

Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing

Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells

Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging

Dysregulated Anti-Viral Innate Immune Cascade During Aging

Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation

STING sensing of murine cytomegalovirus alters the tumor microenvironment to promote antitumor immunity

α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control

Chronic lymphocytic choriomeningitis infection causes susceptibility to mousepox and impairs natural killer cell maturation and function

Loss of resistance to mousepox during chronic lymphocytic choriomeningitis virus infection is associated with impaired T-cell responses and can be rescued by immunization

Langerhans Cells Orchestrate the Protective Antiviral Innate Immune Response in the Lymph Node

Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding

Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node

With some risk-taking and luck: A veterinarian’s adventures in viral immunology

Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

Activation of CD8 T Lymphocytes during Viral Infections

The Pathogenesis and Immunobiology of Mousepox

The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment

Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth

Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection

Protective CD8+ T cell memory without help