Anikeeva N, Panteleev S, Mazzanti NW, Terai M, Sato T, Sykulev Y.: Efficient killing of tumor cells by CAR-T cells demands engagement of a larger number of CARs as opposed to TCRs. Journal of Biological Chemistry 2021, 297(3):101033.  doi:10.1016/jbc.2021.101033

This study investigated the controlling molecular mechanisms for activating stimulatory peptide-MHC ligand on CAR- or TCR- T cells. Understanding the differences in molecular mechanisms contributes to improving the efficacy of cytolytic responses for targeting immunotherapy.

Ohara M, Saito K, Kageyama K, Terai M, Cheng H, Aplin AE, Sato T.: Dual Targeting of CDK4/6 and cMET in Metastatic Uveal Melanoma. Cancers 2021 4;13(5):1104. Doi:10.3390/cancers13051104 

Terai, M., Kageyama, K., Sugase, T., Lam, B.Q., Alexeev, V. and Sato, T. (2021) Orthotopic Human Metastatic Uveal Melanoma Xenograft Mouse Models: Applications for Understanding the Pathophysiology and Therapeutic Management of Metastatic Uveal Melanoma. Curr Protoc, 1, e110.

The mouse models generated from human metastatic uveal melanoma cell lines or patients’ biopsy specimens implanted into the mice liver to represent the similar tumor microenvironment were compared to mouse model with subcutaneous tumor. Drug efficacy was investigated in vitro and using the liver mouse model.