1020 Locust Street
Jefferson Alumni Hall, Room 412C
Philadelphia, PA 19107
Publications
Zheng Ruan*, Emery Haley*, Ian Orozco*, Rebecca Roth, Mark Sabat, Richard Myers, Wei Lu#, Juan Du#. Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat Struct Mol Biol. (2021) Jun 24: 28(7):604-613. DOI: 10.1038/s41594-021-00607-4.
Zheng Ruan*, James Osei-Owusu*, Juan Du, Zhaozhu Qiu#, Wei Lü#. Structures and pH sensing mechanism of the proton-activated chloride channel. Nature. (2020) Nov 04: 588(7837): 350-354. DOI: 10.1038/s41586-020-2875-7.
Zheng Ruan, Ian Orozco, Juan Du#, Wei Lü#. Structures of human Pannexin 1 reveal ion pathways and mechanisms of gating. Nature. (2020) Jun 03: 584(7822):646-651. DOI: 10.1038/s41586-020-2357-y.
Zheng Ruan, Natarajan Kannan. Altered conformational landscape and dimerization dependence underpin the activation of EGFR by αC-β4 loop insertion mutations. PNAS. 2018 Aug 13; 115 (35) E8162-E8171 DOI: doi.org/10.1073/pnas.1803152115.
Recent Peer-Reviewed Publications
- Inhibition of the proton-activated chloride channel PAC by PIP2
- Molecular determinants of pH sensing in the proton-activated chloride channel
- Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC
- Author Correction: Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition (Nature Structural & Molecular Biology, (2021), 28, 7, (604-613), 10.1038/s41594-021-00607-4)
- Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition
- Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
- Structures and pH-sensing mechanism of the proton-activated chloride channel
- Structures of human pannexin 1 reveal ion pathways and mechanism of gating
- Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease
- LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena
- Two antagonistic hippo signaling circuits set the division plane at the medial position in the ciliate tetrahymena
- Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources
- Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1
- Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations
- Coupled regulation by the juxtamembrane and sterile motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution
- Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation
- The hippo pathway maintains the equatorial division plane in the Ciliate Tetrahymena
- Computational and experimental characterization of patient derived mutations reveal an unusual mode of regulatory Spine assembly and drug sensitivity in EGFR kinase
- Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity
- Erratum: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization (PLoS Genet (2016) 12:2 (e1005885) DOI: 10.1371/journal.pgen.1005885)