Nevalainen Research

Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia. Molecular Cancer Therapeutics (AACR). 2015 Aug;14(8):1777-93 PMCID: PMC4547362. Highlighted article and cover of the August 2015 issue.

Talati PG, Gu L, Ellsworth EM, Girondo MA, Trerotola M, Hoang DT, Leiby B, Dagvadorj A, McCue PA, Lallas CD, Trabulsi EJ, Gomella L, Aplin AE, Languino L, Fatatis A, Rui H, Nevalainen MT. Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer. Am J Pathol. 2015 Sep;185(9):2505-22 PMCID: PMC4597281. Subject of an Editorial.

Hoang DT Iczkowski KA, Kilari D, See W, Nevalainen MT; Androgen Receptor-Dependent and -Independent Mechanisms Driving Prostate Cancer Progression: Opportunities for Therapeutic Targeting from Multiple Angles. Oncotarget2017 Jan 10, 8(2) 3724-3745. PMCID: PMC5356914.

Bassem R. Haddad, Andrew Erickson, Vindhya Udhane, Peter LaViolette, Janice D. Rone, Markku Kallajoki, William See, Antti Rannikko, Tuomas Mirtti, Marja T. Nevalainen. Positive STAT5 Protein and Locus Amplification Status Predicts Prostate Cancer Recurrence After Radical Prostatectomy to Assist Precision Medicine of Prostate Cancer. Cancer Epidemiology, Biomarkers and Prevention (AACR). 2019 Oct;28(10):1642-1651. PMCID: PMC6774884.

Vindhya Udhane, Cristina Maranto, David T. Hoang, Lei Gu, Andrew Erickson, Savita Devi, Pooja G. Talati, Anjishnu Banerjee, Kenneth Iczkowski, Kenneth Jacobsohn, William See, Tuomas Mirtti, Deepak Kilari, Marja T. Nevalainen. Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors. Molecular Cancer Therapeutics (AACR). 2020 Jan;19(1):231-246. PMCID: PMC6946850.

Maranto C, Udhane V, Jing J, Verma RS, Fahrenkamp D, Muller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT. Prospects for clinical development of Stat5 inhibitor IST5-002: High transcriptomic specificity in prostate cancer and low toxicity in vivo. Cancers (Basel), 2020 Nov18;12(11):3412.doi.10.3390/cancers12113412. PMCID: PMC7724566.

Beinhoff P, Maranto C, Udhane V, Sabharwal L, See W, Jacobsohn K, Iczkowski K, Hall W, Kilari D, Nevalainen MT. Second-Generation Jak2 Inhibitors for Advanced Prostate Cancer: Are We Ready for Clinical Development? Invited Review, Cancers (Basel), 2021 Oct 17; 13(20):5204. PMCID: PMC8533841

Maranto C*, Udhane VU*, Sabharwal L*, Pitzen S, McCluskey B, Devi S, Johnson S, Jacobsohn K, Banerjee A, Iczkowksi KA, Wang L, Dehm S, Nevalainen MT. Stat5 induces androgen receptor (AR) gene transcription in prostate cancer and offers a druggable pathway to target androgen receptor signaling. In Revision, Science Advances, 2023.