McMahon Research

Contact

Name: Steven McMahon, PhD
Position: Professor

233 South 10th Street
609 BLSB
Philadelphia, PA 19107

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Highlighted Publications

Victoria J. Gennaro, Timothy J. Stanek, Amy R. Peck, Yunguang Sun, Feng Wang, Shuo Qie, Karen E. Knudsen, Hallgeir Rui, Tauseef Butt, J. Alan Diehl, and Steven B. McMahon. Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.  Proceedings of the National Academy of Sciences of the United States of America. 115: 298 - 307.

Recent Publications

A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer

Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates

The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22

Unlocking p53 response elements: DNA shape is the key

The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer

USP22 functions as an oncogenic driver in prostate cancer by regulating cell proliferation and DNA repair

Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC

Rapid detection of p53 acetylation status in response to cellular stress signaling

Lung-enriched mutations in the p53 tumor suppressor: A paradigm for tissue-specific gain of oncogenic function

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation

Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes

A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction

Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer

Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres

The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness

Retraction Notice to: Nuclear receptor function requires a TFTC-type histone acetyl transferase complex

MYC and the control of apoptosis

USP22 regulates oncogenic signaling pathways to drive lethal cancer progression

The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)

P53: The TRiC Is Knowing When to Fold 'Em

Dachshund binds p53 to block the growth of lung adenocarcinoma cells

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer

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