Mahoney Research
Contact
Positions:
- Professor, Pharmacology, Physiology, & Cancer Biology
- Professor, Department of Otolaryngology – Head & Neck Surgery
233 South 10th Street
BLSB Suite 428
Philadelphia, PA 19107
Email:
My.Mahoney@jefferson.edu
Contact Number(s):
- 215-503-3240
- 215-503-1847 (Lab)
Highlighted Publication
Hill, BL, Calder, AN, Flemming, JP, et al. IL-8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR-146a mediated mechanism. Molecular Carcinogenesis. ;2023 62: 1428-1443. doi:10.1002/mc.23587
Therapy using anti-PD-1 immune checkpoint inhibitors (ICI) has revolutionized the treatment of many cancers including head and neck squamous cell carcinomas (HNSCC)
Publications
- Extracellular Vesicles in the Skin Microenvironment: Emerging Roles as Biomarkers and Therapeutic Tools in Dermatologic Health and Disease
- A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
- IL-8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR-146a mediated mechanism
- Nivolumab and ipilimumab in combination with radiotherapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck
- Desmoglein-2 as a cancer modulator: friend or foe?
- Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway
- Desmoglein-2 is important for islet function and β-cell survival
- Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma
- Cytokine Profiling in Low- and High-Density Small Extracellular Vesicles from Epidermoid Carcinoma Cells
- LIPID RAFTS AND CELL ADHESION: MUTUAL MODULATORS OF CELL SIGNALING
- miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas
- Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression
- Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion
- Metformin clinical trial in HPV+ and HPV-head and neck squamous cell carcinoma: Impact on cancer cell apoptosis and immune infiltrate
- Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris
- Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration
- Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes
- Palmitoylation of desmoglein 2 is a regulator of assembly dynamics and protein turnover
- C-Src/Cav1-dependent activation of the EGFR by Dsg2
- Expression of transforming growth factor-β after different non-invasive facial rejuvenation modalities