Languino Research

Contact

Name: Lucia R. Languino, PhD
Position: Professor, Pharmacology, Physiology, Cancer Biology

233 S. 10th Street
BLSB 506
Philadelphia , PA 19107

Contact Number(s):

Highlighted Publications

Please follow the linked titles for full publication.

Quaglia, F., Krishn, S.R., Sossey-Alaoui,K., Rana, P., Pluskota, E., Park, P.H., Shields, C.D., Lin, S., McCue, P., Kossenkov, A.V., Wang, Y., Goodrich, D.W., Ku, S.Y., Beltran, H., Kelly, W.K., Corey, E., Klose, M., Bandtlow, C., Liu, Q.,  Altieri, D.C., Plow, E.F., Languino, L.R. The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer. Scientific Reports (2022); 12(1):18879. DOI: 10.1038/s41598-022-21711-5. PMCID: PMC9640716

Quaglia, F., Krishn, S.R., Sarker, S., Pippa, R., Domingo-Domenech, J., Kumar, G., Fortina, P., Liu, Q., Languino, L.R.  Small extracellular vesicles modulated by the αVβ3 integrin induce neuroendocrine differentiation in prostate cancer, Journal of Extracellular Vesicles (2020). PMCID: PMC7448905

Krishn, S.R., Salem, I., Quaglia, F., Naranjo, N., Agarwal, E., McCue, P.A., Weinreb, PH.H., Violette, S.M., Altieri, D.C., Languino, L.R. The αVβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis, Journal of Extracellular Vesicles (2020). PMCID: PMC7301698

Lu, H., Bowler, N., Harshyne, L., Hooper, D.C., Krishn, S.R., Kurtoglu, S., Fedele, C., Liu, Q., Tang, H., Kossenkov, A.V., Kelly, W.K., Wang, K., Kean, R.B., Weinreb, P.H., Yu, L., Dutta, A., Fortina, P., Ertel, A., Stanczak, M., Forsberg, F., Gabrilovich, D.I., Speicher, D.W., Altieri, D.C. and Languino, L.R. Exosomal ανβ6 Integrin Is Required for Monocyte M2 Polarization in Prostate Cancer. Matrix Biology (2018); 70:20-35. DOI: 10.1016/j.matbio.2018.03.009 [Epub ahead of print]. PMCID: PMC6081240. 

Fedele, C., Singh A., Zerlanko, B., Violette, S.M., Iozzo, R. and Languino, L.R.  The αvβ6 Integrin is Transferred Intercellularly via Exosomes. J. Biol. Chem. (2015). 290(8):4545-4551. [This article was featured in ASBMB Today 2015 and in Faculty 1000 Jones J and Hopkinson S: F1000Prime Recommendation of [Fedele C et al., J. Biol. Chem. 2015; 290(8):4545-4551. In F1000Prime, 2015].  DOI: 10.1074/jbc.C114.617662. PMCID: PMC4335196. 

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