Languino Research

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Verrillo CE, Quaglia F, Shields CD, Lin S, Kossenkov AV, Tang HY, Speicher D, Naranjo NM, Testa A, Kelly WK, Liu Q, Leiby B, Musante L, Sossey-Alaoui K, Dogra N, Chen TY, Altieri DC, Languino LR. Expression of the αVβ3 integrin affects prostate cancer sEV cargo and density and promotes sEV pro-tumorigenic activity in vivo through a GPI-anchored receptor, NgR2. J Extracell Vesicles. 2024 Aug;13(8):e12482. doi: 10.1002/jev2.12482.PMID: 39105261

Naranjo NM, Kennedy A, Testa A, Verrillo CE, Altieri AD, Kean R, Hooper DC, Yu J, Zhao J, Abinader O, Pickles MW, Hawkins A, Kelly WK, Mitra R, Languino LR. Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma. Cancer Biol Ther. 2024 Dec 31;25(1):2364433. doi: 10.1080/15384047.2024.2364433. Epub 2024 Jun 26.PMID: 38926911 

Krishn, S.R., Salem, I., Quaglia, F., Naranjo, N., Agarwal, E., McCue, P.A., Weinreb, PH.H., Violette, S.M., Altieri, D.C., Languino, L.R. The αVβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis, Journal of Extracellular Vesicles (2020). PMCID: PMC7301698

Testa A, Quaglia F, Naranjo NM, Verrillo CE, Shields CD, Lin S, Pickles MW, Hamza DF, Von Schalscha T, Cheresh DA, Leiby B, Liu Q, Ding J, Kelly WK, Hooper DC, Corey E, Plow EF, Altieri DC, Languino LR. Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer. Matrix Biol. 2023 Dec;124:49-62. doi: 10.1016/j.matbio.2023.11.003. Epub 2023 Nov 11.PMID: 37956856

Fedele, C., Singh A., Zerlanko, B., Violette, S.M., Iozzo, R. and Languino, L.R.  The αvβ6 Integrin is Transferred Intercellularly via Exosomes. J. Biol. Chem. (2015). 290(8):4545-4551. [This article was featured in ASBMB Today 2015 and in Faculty 1000 Jones J and Hopkinson S: F1000Prime Recommendation of [Fedele C et al., J. Biol. Chem. 2015; 290(8):4545-4551. In F1000Prime, 2015].  DOI: 10.1074/jbc.C114.617662. PMCID: PMC4335196.