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Research
Research

Felix Kim Research

Contact

Felix Kim, PhD
Professor

233 S 10th Street
908 BLSB
Philadelphia, PA

Highlighted Publications

Maher CM, Thomas JD, Haas DA, Oyer HM, Tong JY, Kim FJ. Small Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1. Molecular Cancer Research. 2018 Feb;16(2):243-255. doi: 10.1158/1541-7786.MCR-17-0166. PMID: 29117944 (*cover article and highlighted in the issue)

Thomas JD, Longen CG, Chen N, Oyer HM, Maher, CM, Salvino JM, Kania B, Ostrander W, Anderson KN, Knudsen KE, Kim FJ. Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer. Cancer Research. 2017 Feb 24. pii: canres.1055.2016. PMID: 28235766; PMC5462524

Kim FJ and Maher CM. Sigma1 Pharmacology in the Context of Cancer. Handb Exp Pharmacol. 2017 Sep 5. PubMed PMID: 28871306

Kim FJ. Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors. Handb Exp Pharmacol. 2017 Sep 5. PubMed PMID: 28871306

Schrock JM, Spino CM, Longen CG, Stabler SM, Marino JC, Pasternak GW, Kim FJ. Sequential cytoprotective responses to Sigma1 ligand-induced endoplasmic reticulum stress. Mol Pharmacol 84:751-762 (2013). PMCID: PMC3807076; PMC3807076

Recent Publications

A student-community partnership to enhance cancer research training

Prostein expression on circulating tumor cells as a prognostic marker in metastatic castration-resistant prostate cancer

Sigma1 Regulates Lipid Droplet-Mediated Redox Homeostasis Required for Prostate Cancer Proliferation

Review of Cardiovascular Risk of Androgen Deprivation Therapy and the Influence of Race in Men with Prostate Cancer

Haloperidol and Prostate Cancer Prevention: More Epidemiologic Research Needed

Small-molecule modulators of sigma1 and SiGma2/TMEM97 in the context of cancer: Foundational concepts and emerging themes

σ1 Receptor ligand binding: an open-and-shut case

Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1

Cloning the sigma2 receptor: Wandering 40 years to find an identity

Sigma1 targeting to suppress aberrant androgen receptor signaling in prostate cancer

The purpose of repurposing

Introduction to sigma proteins: Evolution of the concept of sigma receptors

Sigma1 pharmacology in the context of cancer

Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer

Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation

Sequential cytoprotective responses to Sigma1 ligand-induced endoplasmic reticulum stress

Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression

σ1 Receptor modulation of G-protein-coupled receptor signaling: Potentiation of opioid transduction independent from receptor binding

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