Harshyne Research
Contact
        Name: 
        
             Larry Harshyne, PhD
        
        
    
    
            Position: 
            
        
        
        - Assistant Professor, Department of Microbiology & Immunology
 - Assistant Provost, Research Conduct & Compliance
 - Director, Sidney Kimmel Comprehensive Cancer Center Flow Cytometry & Human Immune Monitoring Core
 
                Jefferson Alumni Hall
                1020 Locust Street, M-41
                Philadelphia, PA 19107
            
            Contact Number(s): 
            
        
        
    Publications
- Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysis
 - Response-Adaptive Surgical Timing in Neoadjuvant Immunotherapy Demonstrates Enhanced Pathologic Treatment Response in Head and Neck Squamous Cell Carcinoma
 - The impact of biomaterial characteristics on macrophage phenotypes in tissue engineering: a review
 - Predictive capacity of immune-related adverse events and cytokine profiling in neoadjuvant immune checkpoint inhibitor trials for head and neck squamous cell carcinoma
 - Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma
 - IL-8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR-146a mediated mechanism
 - Nivolumab and ipilimumab in combination with radiotherapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck
 - CD8+ and FoxP3+ T-Cell Cellular Density and Spatial Distribution After Programmed Death-Ligand 1 Check Point Inhibition
 - Intracellular monitoring by dendritic cells – a new way to stay informed – from a simple scavenger to an active gatherer
 - Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma
 - Cytokine Profiling in Low- and High-Density Small Extracellular Vesicles from Epidermoid Carcinoma Cells
 - Systemic immune bias delineates malignant astrocytoma survival cohorts
 - Phase Ib clinical trial of IGV-001 for patients with newly diagnosed glioblastoma
 - Discordant Responses Between Primary Head and Neck Tumors and Nodal Metastases Treated With Neoadjuvant Nivolumab: Correlation of Radiographic and Pathologic Treatment Effect
 - Cancer-Associated Fibroblast Density, Prognostic Characteristics, and Recurrence in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis
 - A Pilot Study of Radiation Therapy in Combination with Pembrolizumab in Patients with Metastatic Renal Cell Cancer
 - miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas
 - Prognostic Significance of Tumor-Associated Macrophage Content in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis
 - Loss of CD169+ Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma
 - Metformin clinical trial in HPV+ and HPV-head and neck squamous cell carcinoma: Impact on cancer cell apoptosis and immune infiltrate