Goldsmith Research
233 South 10th Street
BLSB, Room 306
Philadelphia, PA 19107
Highlighted Publications
Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF. Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons. Neuron 2022 Jan 13 PMID:35051374
Goldsmith J, Ordureau A, Stavoe AKH, Boecker CA, Arany M, Harper JW, Holzbaur ELF. Distinct adaptations revealed by unbiased proteomic analysis of autophagy cargos in the brain of PINK1 and LRRK2 models of Parkinson’s disease. Manuscript on BioRxiv. https://doi.org/10.1101/2022.10.03.510717
Boecker CA, Goldsmith J, Dou D, Cajka GG, Holzbaur ELF. Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes. Current Biology 2021 Mar 18 PMID:33765413
Publications
- Autophagic stress activates distinct compensatory secretory pathways in neurons
- Erratum: Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons (Neuron (2022) 110(6) (967–976.e8), (S0896627321010461), (10.1016/j.neuron.2021.12.029))
- Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation (Nature Communications, (2018), 9, 1, (476), 10.1038/s41467-017-02811-7)
- Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
- Proteomic profiling shows mitochondrial nucleoids are autophagy cargo in neurons: implications for neuron maintenance and neurodegenerative disease
- Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway
- Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis
- Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomyces cerevisiae
- Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
- Ribosome profiling reveals a functional role for autophagy in mRNA translational control
- Presynaptic Homeostatic Plasticity Staves off Neurodegenerative Pathophysiology up to a Tipping Point
- The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles
- Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
- Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment
- NBR 1 enables autophagy-dependent focal adhesion turnover
- A novel biosensor for quantitative monitoring of on-target activity of paclitaxel
- Autophagy and cancer metabolism
- A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer
- Modulating microtubule stability enhances the cytotoxic response of cancer cells to paclitaxel
- Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly