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Deshpande Research

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Deepak Deshpande, DVM, PhD
Professor

Highlighted Publications

Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nature Medicine. 2011 Jul 7; 17(7):776-8.

Defnet A, Huang W, Polischak SR, Kane M, Shapiro P, Deshpande DA. Effect of ATP-competitive and function selective ERK inhibitors on ASM cell proliferation. FASEB J. 2019 Jul 26:fj201900680R.

Pan S, Shah S, Panettieri, RA, Deshpande DA. Regulation of airway smooth muscle adhesion and proliferation by Bnip3. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11. doi: 10.1152/ajplung.00224.2019.

Singh BK, Lu W, Schmidt Paustian AM, Ge M, Koziol-White CJ, Wang N, Sommers C, Riese M, Samuelson L, Deshpande DA, Panettieri RA, Haczku A, Kambayashi T. Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. Sci Signal. 2019 Sep 3;12(597).

Nayak AP, Villalba D, Deshpande DA. Bitter taste receptors: an answer to comprehensive asthma control? Curr Allergy Asthma Rep. 2019 Sep 5;19(10):48.

Recent Publications

Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle

A-Kinase–Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle

CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1

Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease

Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle

Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma

Superoxide Anions Inhibit Intracellular Calcium Response in Porcine Airway Smooth Muscle Cells

Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2 Signaling in Airway Smooth Muscle

Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation

Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma

Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation

Proteomics-Based Approach for Detailing the Allergenic Profile of Cannabis Chemotypes

Comparing Performance of Spectral Image Analysis Approaches for Detection of Cellular Signals in Time-Lapse Hyperspectral Imaging Fluorescence Excitation-Scanning Microscopy

Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice

In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signaling and function

A cryptic mode of GPCR regulation revealed

PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells

Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma

Bitter Taste Receptors in the Airway Cells Functions

Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase

Measurement of agonist-induced Ca2+signals in human airway smooth muscle cells using excitation scan-based hyperspectral imaging and image analysis approaches

Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma

OGR1-dependent regulation of the allergen-induced asthma phenotype

Diacylglycerol kinase inhibition reduces airway contraction by negative feedback regulation of gq-signaling

Nur77 attenuates inflammasome activation by inhibiting caspase-1 expression in pulmonary vascular endothelial cells

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