Deshpande Research

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Name: Deepak Deshpande, DVM, PhD
Position: Professor

Highlighted Publications

Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nature Medicine. 2011 Jul 7; 17(7):776-8.

Defnet A, Huang W, Polischak SR, Kane M, Shapiro P, Deshpande DA. Effect of ATP-competitive and function selective ERK inhibitors on ASM cell proliferation. FASEB J. 2019 Jul 26:fj201900680R.

Pan S, Shah S, Panettieri, RA, Deshpande DA. Regulation of airway smooth muscle adhesion and proliferation by Bnip3. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11. doi: 10.1152/ajplung.00224.2019.

Singh BK, Lu W, Schmidt Paustian AM, Ge M, Koziol-White CJ, Wang N, Sommers C, Riese M, Samuelson L, Deshpande DA, Panettieri RA, Haczku A, Kambayashi T. Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. Sci Signal. 2019 Sep 3;12(597).

Nayak AP, Villalba D, Deshpande DA. Bitter taste receptors: an answer to comprehensive asthma control? Curr Allergy Asthma Rep. 2019 Sep 5;19(10):48.

Recent Publications

Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma

Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2 Signaling in Airway Smooth Muscle

Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation

Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation

Proteomics-Based Approach for Detailing the Allergenic Profile of Cannabis Chemotypes

Comparing Performance of Spectral Image Analysis Approaches for Detection of Cellular Signals in Time-Lapse Hyperspectral Imaging Fluorescence Excitation-Scanning Microscopy

Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice

In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signaling and function

PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells

A cryptic mode of GPCR regulation revealed

Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma

Bitter Taste Receptors in the Airway Cells Functions

Measurement of agonist-induced Ca2+signals in human airway smooth muscle cells using excitation scan-based hyperspectral imaging and image analysis approaches

Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase

OGR1-dependent regulation of the allergen-induced asthma phenotype

Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma

Diacylglycerol kinase inhibition reduces airway contraction by negative feedback regulation of gq-signaling

Nur77 attenuates inflammasome activation by inhibiting caspase-1 expression in pulmonary vascular endothelial cells

Chloroquine: Autophagy inhibitor, antimalarial, bitter taste receptor agonist in fight against COVID-19, a reality check?

The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR

Editorial overview: Pulmonary 2020 – advances in the pharmacology of obstructive lung diseases

The role of diacylglycerol kinases in allergic airway disease

Therapeutic potential and challenges of bitter taste receptors on lung cells

Role of CD38/cADPR signaling in obstructive pulmonary diseases

A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation

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