Deshpande Research

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Name: Deepak Deshpande, DVM, PhD
Position: Professor

Highlighted Publications

Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nature Medicine. 2011 Jul 7; 17(7):776-8.

Defnet A, Huang W, Polischak SR, Kane M, Shapiro P, Deshpande DA. Effect of ATP-competitive and function selective ERK inhibitors on ASM cell proliferation. FASEB J. 2019 Jul 26:fj201900680R.

Pan S, Shah S, Panettieri, RA, Deshpande DA. Regulation of airway smooth muscle adhesion and proliferation by Bnip3. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 11. doi: 10.1152/ajplung.00224.2019.

Singh BK, Lu W, Schmidt Paustian AM, Ge M, Koziol-White CJ, Wang N, Sommers C, Riese M, Samuelson L, Deshpande DA, Panettieri RA, Haczku A, Kambayashi T. Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms. Sci Signal. 2019 Sep 3;12(597).

Nayak AP, Villalba D, Deshpande DA. Bitter taste receptors: an answer to comprehensive asthma control? Curr Allergy Asthma Rep. 2019 Sep 5;19(10):48.

Recent Publications

CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1

Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease

Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle

Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma

Superoxide Anions Inhibit Intracellular Calcium Response in Porcine Airway Smooth Muscle Cells

Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma

Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2 Signaling in Airway Smooth Muscle

Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation

Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation

Proteomics-Based Approach for Detailing the Allergenic Profile of Cannabis Chemotypes

Comparing Performance of Spectral Image Analysis Approaches for Detection of Cellular Signals in Time-Lapse Hyperspectral Imaging Fluorescence Excitation-Scanning Microscopy

Targeted Inhibition of Select Extracellular Signal-regulated Kinases 1 and 2 Functions Mitigates Pathological Features of Asthma in Mice

In silico identification of a β2-adrenoceptor allosteric site that selectively augments canonical β2AR-Gs signaling and function

PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells

A cryptic mode of GPCR regulation revealed

Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma

Bitter Taste Receptors in the Airway Cells Functions

Measurement of agonist-induced Ca2+signals in human airway smooth muscle cells using excitation scan-based hyperspectral imaging and image analysis approaches

Autocrine regulation of airway smooth muscle contraction by diacylglycerol kinase

OGR1-dependent regulation of the allergen-induced asthma phenotype

Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma

Diacylglycerol kinase inhibition reduces airway contraction by negative feedback regulation of gq-signaling

Nur77 attenuates inflammasome activation by inhibiting caspase-1 expression in pulmonary vascular endothelial cells

Chloroquine: Autophagy inhibitor, antimalarial, bitter taste receptor agonist in fight against COVID-19, a reality check?

The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR

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