Cupo Research
Name:
Ryan Cupo, PhD
Position:
Assistant Professor, Department of Pathology & Genomic Medicine
Organization:
Sidney Kimmel Medical College
1020 Locust Street
Suite 527A
Philadelphia, PA 19107
Email:
Ryan.Cupo@jefferson.edu
Contact Number(s):
Highlighted Publications
- The mitochondrial intermembrane space nuclease Nuc1 (endonuclease G) prevents mitophagy-mediated mtDNA escape in yeast
- Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB
- Erratum: Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy (Cell Reports (2025) 44(1), (S2211124724015560), (10.1016/j.celrep.2024.115205))
- Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
- Decoding Skd3 (Human CLPB): A Mitochondrial Protein Disaggregase Critical for Human Health
- Tuning Hsp104 specificity to selectively detoxify α-synuclein
- Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3
- Heterozygous variants of CLPB are a cause of severe congenital neutropenia
- Skd3 (Human clpb) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations
- Expression and Purification of Recombinant Skd3 (Human ClpB) Protein and Tobacco Etch Virus (TEV) Protease from Escherichia coli
- Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges
- Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity