Cho, S.-H. *, Nahar, A., Kim, J.H., Lee, M., Kozmik Z., and Kim, S. Targeted deletion of Crb1/Crb2 in the optic vesicle models key features of Leber congenital amaurosis 8 (2019) Dev. Biol. 453(2):141-54.

This mouse model generated by conditional ablation of both Crb1 and Crb2 genes from the beginning of the eye development represents the most advanced in vivo model of LCA8 manifesting major features of human LCA8.

Lee, M., Goraya, N., Kim, S., and Cho, S.-H.*. Hippo-Yap signaling in ocular development and disease (2018) Dev. Dyn. 247(6):794-806.

Kim, J. Y., Park, R., Lee, J. H., Nickas, J., Kim, S., and Cho, S.-H.*  Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye (2016) Dev. Biol. Nov. 15;419(2):336-47.

This study first demonstrates that Yap is necessary for multiple developmental processes during eye development such as maintenance of the retinal progenitor pool, fate-determination of retinal pigment epithelium, stability of the apical junctions of the retinal epithelium.

Cho, S.-H.*, Song J. Y., Shin, J., Kim, S. Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model (2016) BMC Ophthalmol. Nov. 4;16(1):193

This study identifies two major barriers in cell transplantation therapy using mouse model: host immune responses and formation of a physical barrier resulting from disruption of outer limiting membrane of the retinal epithelium.

Kim, J.Y., Song, J.Y., Karnam, S., Park, J.Y., Lee, J.J., Kim, S., and Cho, S.-H.* Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye. (2015) Gene Expr. Patterns. 17 (1) 31-7.

This study identifies unexpected localization of Crumbs complex proteins in the Golgi and nucleus of the subset of retinal progenitor cells in addition to common, apical localization in developing retina and lens.

Song, J.Y., Park. R., Kim, J.Y., Hughes, L., Lu, L., Kim S., Johnson R.L., and Cho, S.-H.* Dual function of Yap in the regulation of lens progenitor cells and cellular polarity (2014) Dev. Biol. 386, 281-90.

This study illustrates canonical and non-canonical functions of Yap signaling during growth and development of lens. Yap is required for the proliferation and timely-exit of lens progenitor cells (canonical) while it is crucial for maintenance of organelle polarity and cell shape (non-canonical).