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Cho Research

Contact

Name: Seo-Hee Cho, PhD
Position: Director, Vision Research Core Facility

1020 Locust Street
JAH 425G
Philadelphia, PA 19107

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Highlighted Publications

Cho, S.-H. *, Nahar, A., Kim, J.H., Lee, M., Kozmik Z., and Kim, S. Targeted deletion of Crb1/Crb2 in the optic vesicle models key features of Leber congenital amaurosis 8 (2019) Dev. Biol. 453(2):141-54.

This mouse model generated by conditional ablation of both Crb1 and Crb2 genes from the beginning of the eye development represents the most advanced in vivo model of LCA8 manifesting major features of human LCA8.

 

Lee, M., Goraya, N., Kim, S., and Cho, S.-H.*. Hippo-Yap signaling in ocular development and disease (2018) Dev. Dyn. 247(6):794-806.

Kim, J. Y., Park, R., Lee, J. H., Nickas, J., Kim, S., and Cho, S.-H.*  Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye (2016) Dev. Biol. Nov. 15;419(2):336-47.

This study first demonstrates that Yap is necessary for multiple developmental processes during eye development such as maintenance of the retinal progenitor pool, fate-determination of retinal pigment epithelium, stability of the apical junctions of the retinal epithelium.

Cho, S.-H.*, Song J. Y., Shin, J., Kim, S. Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model (2016) BMC Ophthalmol. Nov. 4;16(1):193

This study identifies two major barriers in cell transplantation therapy using mouse model: host immune responses and formation of a physical barrier resulting from disruption of outer limiting membrane of the retinal epithelium.

Kim, J.Y., Song, J.Y., Karnam, S., Park, J.Y., Lee, J.J., Kim, S., and Cho, S.-H.* Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye. (2015) Gene Expr. Patterns. 17 (1) 31-7.

This study identifies unexpected localization of Crumbs complex proteins in the Golgi and nucleus of the subset of retinal progenitor cells in addition to common, apical localization in developing retina and lens.

Song, J.Y., Park. R., Kim, J.Y., Hughes, L., Lu, L., Kim S., Johnson R.L., and Cho, S.-H.* Dual function of Yap in the regulation of lens progenitor cells and cellular polarity (2014) Dev. Biol. 386, 281-90.

This study illustrates canonical and non-canonical functions of Yap signaling during growth and development of lens. Yap is required for the proliferation and timely-exit of lens progenitor cells (canonical) while it is crucial for maintenance of organelle polarity and cell shape (non-canonical). 

Recent Publications

Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model

Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis

An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis

Current perspectives in Leber congenital amaurosis type 8 mouse modeling

Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex

De novo variants in MPP5 cause global developmental delay and behavioral changes

Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation

Targeted deletion of Crb1/Crb2 in the optic vesicle models key features of leber congenital amaurosis 8

Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death

Hippo-yap signaling in ocular development and disease

YAP/TAZ initiate and maintain schwann cell myelination

Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye

Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model

Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state

Impaired Reelin-Dab1 signaling contributes to neuronal migration deficits of tuberous sclerosis complex

Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye

Dual function of Yap in the regulation of lens progenitor cells and cellular polarity

Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex

Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of leber congenital amaurosis

Cadherin-11 contributes to pulmonary fibrosis: Potential role in TGF-β production and epithelial to mesenchymal transition

The Apical Complex Couples Cell Fate and Cell Survival to Cerebral Cortical Development

Identification of genes expressed preferentially in the developing peripheral margin of the optic cup

Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property

Wnt2b/β-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye