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Clinical Briefs

HPV Vaccine’s Expanded Role in Cancer Prevention

By Queen Muse | Illustrations By Matt Chinworth

While the human papillomavirus (HPV) is historically linked to cervical cancer in women, head and neck cancer has become the most common HPV-associated cancer in the U.S., with a growing prevalence among men. A new study suggests that the HPV vaccine could help beyond its well-known protection against cervical cancer.

The research team, led by otolaryngologist Joseph Curry, MD, analyzed over a million health records of individuals ages nine to 39, comparing the outcomes of vaccinated and unvaccinated groups. Their findings showed that men vaccinated for HPV had a lower risk of developing head and neck cancers, and vaccinated women experienced a reduced risk of cervical cancer and other pre-cancerous conditions.

According to Dr. Curry, it’s a positive step toward addressing misconceptions surrounding the HPV vaccine, especially among groups that may not see themselves as at risk, such as men who mistakenly think the vaccine is only for preventing cervical cancer.

“I hope these results will encourage healthcare providers and policymakers to endorse HPV vaccination initiatives as a measure to prevent cancer on a larger scale,” he says.

The team’s future studies will follow vaccinated individuals as they reach the typical age for developing these cancers, allowing researchers to better assess long-term vaccine efficacy in preventing head and neck, and other HPV-linked cancers.

Preventing Maternal Death Across the Globe

By Jill Adams | Illustrations By Matt Chinworth

One of the leading causes of maternal death is sepsis, a sudden and overwhelming reaction to infection; it is a medical emergency that, once triggered, can be very challenging to interrupt. A recent study by Jefferson researchers, collaborating with global partners, found that a single dose of a common antibiotic can reduce the incidence of sepsis during labor and delivery.

Nearly 30,000 women at eight clinics in seven low- or middle-income countries were assigned to receive either a single dose of azithromycin or a placebo when they went into labor. The antibiotic group experienced a 33% decreased risk of sepsis and maternal death over the placebo group.

“The size of the effect was greatest in Africa — about a 40% reduction,” says Richard Derman, MD, associate provost of Global Health at Jefferson. “It was a little smaller, but still meaningful in South Asia — about 11%.”

The sheer size of the study was made possible by the Global Research Network, which encompasses data collected on over 800,000 deliveries. It is funded by the National Institute of Child Health and Human Development and often supported by the Gates Foundation grants. “Our collaboration has been actively involved in the Network since its inception more than 20 years ago,” says Dr. Derman.

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