Mandeep Kaur

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Fractured Connections: An Invisible Battle and Cellular Struggles in ALS 

This depiction vividly illustrates the lumbar region (L5) of spinal cord of ALS mouse, emphasizing critical roles of astrocytes and microglia. The vibrant colors and intricate patterns reflect the underlying chaos of this condition and cellular battles within the nervous system, urging a deeper understanding of ALS and the vital need for research and support. Astrocytes (green) are showing reactive state, illustrating their struggle to manage the damage caused by motor neuron loss. Microglial activation (red) is indicating immune response to injury. Together, these cellular markers highlight the pathological features of ALS, that severely impacts muscle control and strength.