Zhang Research


Name: Jianke Zhang, PhD
Position: Professor

233 South 10th Street
731 BLSB
Philadelphia, PA 19107

Telephone: 215-503-4559

Highlighted Publications

Zhang, J., Cado, D., Chen, A., Kabra, N. H., and Winoto, A.: Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392:296-300, 1998.

Zhang, H., Zhou, X., McQuade, T., Li, J., Chan, F., and Zhang, J.: Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471(7338):373-376, 2011.

Dowling, J. P., Cai, Y, Bertin, J, Gough, P. J., Zhang. J. Kinase-independent function of RIP1, critical for mature T-cell survival and proliferation. Cell Death Dis. 7(9):e2379, 2016.

Recent Publications

Residual power series method for the time fractional Fornberg-Whitham equation

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

Inhibition of Fas-Associated Death Domain-Containing Protein (FADD) Protects against Myocardial Ischemia/Reperfusion Injury in a Heart Failure Mouse Model

Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis

Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis

RIP1-mediated regulation of lymphocyte survival and death responses

RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury

Functional complementation between FADD and RIP1 in embryos and lymphocytes

FADD deficiency impairs early hematopoiesis in the bone marrow

New robust optimization counterpart for linear optimization with uncertain data

Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells

The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation

A role for cFLIP in B cell proliferation and stress MAPK regulation

The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Critical role for Daxx in regulating Mdm2

The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells

Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency

Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis

Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death

Expression of Stage-Specific Genes during Zygotic Gene Activation in Preimplantation Mouse Embryos

FADD-deficient T Cells Exhibit a Disaccord in Regulation of the Cell Cycle Machinery

T cell-specific FADD-deficient mice: FADD is required for early T cell development

Accelerated Publication - FADD is required for DR4- and DR5-mediated apoptosis. Lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts

Receptor-mediated apoptosis in T lymphocytes