Yu Research

Shiguang Yu, PhD

Contact

Name: Shiguang Yu, PhD
Position: Assistant Professor

900 Walnut Street
Room 300A
Philadelphia, PA 19107

Telephone: 215-955-5032

Post-transcription regulation (PTR) plays a pivotal role for cell quick responses to environmental stimuli. Many cytokine gene expressions are post-transcriptionally regulated by RNA-binding protein and non-coding microRNAs.

Research Projects

Project 1: HuR regulation of TH17 cell differentiation and function in autoimmune neuroinflammation

Our laboratory is focused on understanding how RNA-binding protein HuR regulates immune cell differentiation that contributes to autoimmune inflammation. Specifically, we are interested in studying how HuR modulates T cell differentiation and function in autoimmune neuroinflammation, and that interaction of HuR with microRNAs governs the function and differentiation of immune cells. To do this, we utilize RNA biology, molecular biology, RNA-se, and animal models of human diseases to achieve our goals.

Project 2: Role of HuR and innate cells in neurodegenerative disorders

We are also interested in investigating RNA-binding protein-mediated cytokine production in innate immune cells in neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).

Hopefully, information derived from our proposed studies will improve the understanding of autoimmune neuroinflammation and neurodegenerative diseases, and will help identify novel therapeutic targets to treat these diseases.