Post-transcription regulation (PTR) plays a pivotal role for cell quick responses to environmental stimuli. Many cytokine gene expressions are post-transcriptionally regulated by RNA-binding protein and non-coding microRNAs.
Project 1: HuR regulation of TH17 cell differentiation and function in autoimmune neuroinflammation
Our laboratory is focused on understanding how RNA-binding protein HuR regulates immune cell differentiation that contributes to autoimmune inflammation. Specifically, we are interested in studying how HuR modulates T cell differentiation and function in autoimmune neuroinflammation, and that interaction of HuR with microRNAs governs the function and differentiation of immune cells. To do this, we utilize RNA biology, molecular biology, RNA-se, and animal models of human diseases to achieve our goals.
Project 2: Role of HuR and innate cells in neurodegenerative disorders
We are also interested in investigating RNA-binding protein-mediated cytokine production in innate immune cells in neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).
Hopefully, information derived from our proposed studies will improve the understanding of autoimmune neuroinflammation and neurodegenerative diseases, and will help identify novel therapeutic targets to treat these diseases.